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Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)

  • Authors:
    • Wanlu Ye
    • Nan Xiang
    • Qing Wang
    • Yanming Lu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110003, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 41
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    Published online on: March 5, 2024
       https://doi.org/10.3892/ijmm.2024.5365
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Abstract

Circular RNA (circRNA), a type of non‑coding RNA, plays a regulatory role in biological processes. The special loop structure of circRNA makes it highly stable and specific in diseased tissues and cells, especially in tumors. Competing endogenous RNAs (ceRNAs) compete for the binding of microRNA (miRNA) at specific binding sites and thus regulate gene expression. ceRNAs play an important role in various diseases and are currently recognized as the most prominent mechanism of action of circRNAs. circRNAs can modulate the proliferation, migration, invasion and apoptosis of tumor cells through the ceRNA mechanism. With further research, circRNAs may serve as novel markers and therapeutic targets for ovarian cancer (OC). In the present review, the research progress of circRNAs as ceRNAs in OC was summarized, focusing on the effects of the circRNA/miRNA/mRNA axis on the biological functions of OC cells through mediating pivotal signaling pathways. The role of circRNAs in the diagnosis, prognostic assessment and treatment of OC was also discussed in the present review.
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1 

Siegel RL, Miller KD, Wagle NS and Jemal A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023. View Article : Google Scholar : PubMed/NCBI

2 

La Vecchia C: Ovarian cancer: Epidemiology and risk factors. Eur J Cancer Prev. 26:55–62. 2017. View Article : Google Scholar

3 

Kuroki L and Guntupalli SR: Treatment of epithelial ovarian cancer. BMJ. 371:m37732020. View Article : Google Scholar : PubMed/NCBI

4 

Armstrong DK, Alvarez RD, Backes FJ, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Chitiyo VC, Cristea M, et al: NCCN guidelines® insights: Ovarian cancer, version 3.2022. J Natl Compr Canc Netw. 20:972–980. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Meng S, Zhou H, Feng Z, Xu Z, Tang Y, Li P and Wu M: Circrna: Functions and properties of a novel potential biomarker for cancer. Mol Cancer. 16:942017. View Article : Google Scholar : PubMed/NCBI

6 

Franco-Zorrilla JM, Valli A, Todesco M, Mateos I, Puga MI, Rubio-Somoza I, Leyva A, Weigel D, García JA and Paz-Ares J: Target mimicry provides a new mechanism for regulation of microRNA activity. Nat Genet. 39:1033–1037. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Ebert MS, Neilson JR and Sharp PA: MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells. Nat Methods. 4:721–726. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Tang X, Ren H, Guo M, Qian J, Yang Y and Gu C: Review on circular RNAs and new insights into their roles in cancer. Comput Struct Biotechnol J. 19:910–928. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Ding J, Wang Q, Guo N, Wang H, Chen H, Ni G and Li P: CircRNA circ_0072995 promotes the progression of epithelial ovarian cancer by modulating miR-147a/CDK6 axis. Aging (Albany NY). 12:17209–17223. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Guan X, Zong ZH, Liu Y, Chen S, Wang LL and Zhao Y: circPUM1 promotes tumorigenesis and progression of ovarian cancer by sponging miR-615-5p and miR-6753-5p. Mol Ther Nucleic Acids. 18:882–892. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Mattick JS and Makunin IV: Non-coding RNA. Hum Mol Genet. 15:R17–R29. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Sanger HL, Klotz G, Riesner D, Gross HJ and Kleinschmidt AK: Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci USA. 73:3852–3856. 1976. View Article : Google Scholar : PubMed/NCBI

13 

Cocquerelle C, Mascrez B, Hétuin D and Bailleul B: Mis-splicing yields circular RNA molecules. FASEB J. 7:155–160. 1993. View Article : Google Scholar : PubMed/NCBI

14 

Jeck WR and Sharpless NE: Detecting and characterizing circular RNAs. Nat Biotechnol. 32:453–461. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Suzuki H and Tsukahara T: A view of pre-mRNA splicing from RNase R resistant RNAs. Int J Mol Sci. 15:9331–9342. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Zhang S, Cheng J, Quan C, Wen H, Feng Z, Hu Q, Zhu J, Huang Y and Wu X: circCELSR1 (hsa_circ_0063809) contributes to paclitaxel resistance of ovarian cancer cells by regulating FOXR2 expression via miR-1252. Mol Ther Nucleic Acids. 19:718–730. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Wang F, Nazarali AJ and Ji S: Circular RNAs as potential biomarkers for cancer diagnosis and therapy. Am J Cancer Res. 6:1167–1176. 2016.PubMed/NCBI

18 

Yang X, Mei J, Wang H, Gu D, Ding J and Liu C: The emerging roles of circular RNAs in ovarian cancer. Cancer Cell Int. 20:2652020. View Article : Google Scholar : PubMed/NCBI

19 

Hansen TB, Wiklund ED, Bramsen JB, Villadsen SB, Statham AL, Clark SJ and Kjems J: miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO J. 30:4414–4422. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Huang A, Zheng H, Wu Z, Chen M and Huang Y: Circular RNA-protein interactions: Functions, mechanisms, and identification. Theranostics. 10:3503–3517. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Qu S, Yang X, Li X, Wang J, Gao Y, Shang R, Sun W, Dou K and Li H: Circular RNA: A new star of noncoding RNAs. Cancer Lett. 365:141–148. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Panda AC, Grammatikakis I, Munk R, Gorospe M and Abdelmohsen K: Emerging roles and context of circular RNAs. Wiley Interdiscip Rev RNA. 8: View Article : Google Scholar : 2017.

23 

Su Q and Lv X: Revealing new landscape of cardiovascular disease through circular RNA-miRNA-mRNA axis. Genomics. 112:1680–1685. 2020. View Article : Google Scholar

24 

Su L, Li R, Zhang Z, Liu J, Du J and Wei H: Identification of altered exosomal microRNAs and mRNAs in Alzheimer's disease. Ageing Res Rev. 73:1014972022. View Article : Google Scholar

25 

Zhang J, Luo Q, Li X, Guo J, Zhu Q, Lu X, Wei L, Xiang Z, Peng M, Ou C and Zou Y: Novel role of immune-related non-coding RNAs as potential biomarkers regulating tumour immunoresponse via MICA/NKG2D pathway. Biomark Res. 11:862023. View Article : Google Scholar : PubMed/NCBI

26 

Lu S, Zhu N, Guo W, Wang X, Li K, Yan J, Jiang C, Han S, Xiang H, Wu X, et al: RNA-Seq revealed a circular RNA-microRNA-mRNA regulatory network in hantaan virus infection. Front Cell Infect Microbiol. 10:972020. View Article : Google Scholar : PubMed/NCBI

27 

Yang X, Ye T, Liu H, Lv P, Duan C, Wu X, Jiang K, Lu H, Xia D, Peng E, et al: Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer. Mol Cancer. 20:42021. View Article : Google Scholar : PubMed/NCBI

28 

Najafi S: Circular RNAs as emerging players in cervical cancer tumorigenesis; A review to roles and biomarker potentials. Int J Biol Macromol. 206:939–953. 2022. View Article : Google Scholar : PubMed/NCBI

29 

Najafi S: The emerging roles and potential applications of circular RNAs in ovarian cancer: A comprehensive review. J Cancer Res Clin Oncol. 149:2211–2234. 2023. View Article : Google Scholar

30 

Fattahi M, Shahrabi S, Saadatpour F, Rezaee D, Beyglu Z, Delavari S, Amrolahi A, Ahmadi S, Bagheri-Mohammadi S, Noori E, et al: microRNA-382 as a tumor suppressor? Roles in tumorigenesis and clinical significance. Int J Biol Macromol. 250:1258632023. View Article : Google Scholar : PubMed/NCBI

31 

Pordel S, Khorrami M, Saadatpour F, Rezaee D, Cho WC, Jahani S, Aghaei-Zarch SM, Hashemi E and Najafi S: The role of microRNA-185 in the pathogenesis of human diseases: A focus on cancer. Pathol Res Pract. 249:1547292023. View Article : Google Scholar : PubMed/NCBI

32 

Najafi S, Aghaei Zarch SM, Majidpoor J, Pordel S, Aghamiri S, Fatih Rasul M, Asemani Y, Vakili O, Mohammadi V, Movahedpour A and Arghiani N: Recent Insights into the roles of circular rnas in human brain development and neurologic diseases. Int J Biol Macromol. 225:1038–1048. 2023. View Article : Google Scholar

33 

Xu YX, Pu SD, Li X, Yu ZW, Zhang YT, Tong XW, Shan YY and Gao XY: Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications. Pharmacol Res. 178:1061352022. View Article : Google Scholar : PubMed/NCBI

34 

Wang Y, Liu J, Ma J, Sun T, Zhou Q, Wang W, Wang G, Wu P, Wang H, Jiang L, et al: Exosomal circRNAs: Biogenesis, effect and application in human diseases. Mol Cancer. 18:1162019. View Article : Google Scholar : PubMed/NCBI

35 

Karreth FA and Pandolfi PP: ceRNA cross-talk in cancer: When ce-bling rivalries go awry. Cancer Discov. 3:1113–1121. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell. 146:353–358. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Lan C, Peng H, Hutvagner G and Li J: Construction of competing endogenous RNA networks from paired RNA-seq data sets by pointwise mutual information. BMC Genomics. 20(Suppl 9): S9432019. View Article : Google Scholar

39 

Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB and Kjems J: The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 20:675–691. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Peng Z, Fang S, Jiang M, Zhao X, Zhou C and Gong Z: Circular RNAs: Regulatory functions in respiratory tract cancers. Clin Chim Acta. 510:264–271. 2020. View Article : Google Scholar : PubMed/NCBI

41 

Li R, Jiang J, Shi H, Qian H, Zhang X and Xu W: CircRNA: A rising star in gastric cancer. Cell Mol Life Sci. 77:1661–1680. 2020. View Article : Google Scholar

42 

Rong Z, Xu J, Shi S, Tan Z, Meng Q, Hua J, Liu J, Zhang B, Wang W, Yu X and Liang C: Circular RNA in pancreatic cancer: A novel avenue for the roles of diagnosis and treatment. Theranostics. 11:2755–2769. 2021. View Article : Google Scholar : PubMed/NCBI

43 

Chaichian S, Shafabakhsh R, Mirhashemi SM, Moazzami B and Asemi Z: Circular RNAs: A novel biomarker for cervical cancer. J Cell Physiol. 235:718–274. 2020. View Article : Google Scholar

44 

Razavi ZS, Tajiknia V, Majidi S, Ghandali M, Mirzaei HR, Rahimian N, Hamblin MR and Mirzaei H: Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles. Crit Rev Oncol Hematol. 157:1031922021. View Article : Google Scholar

45 

Sang Y, Chen B, Song X, Li Y, Liang Y, Han D, Zhang N, Zhang H, Liu Y, Chen T, et al: circRNA_0025202 regulates tamoxifen sensitivity and tumor progression via regulating the miR-182-5p/FOXO3a axis in breast cancer. Mol Ther. 27:1638–1652. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Wang J, Zhao X, Wang Y, Ren F, Sun D, Yan Y, Kong X, Bu J, Liu M and Xu S: circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma. Cell Death Dis. 11:322020. View Article : Google Scholar : PubMed/NCBI

47 

Huang G, Liang M, Liu H, Huang J, Li P, Wang C, Zhang Y, Lin Y and Jiang X: CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway. Cell Death Dis. 11:10652020. View Article : Google Scholar

48 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Liu T, Yuan L and Zou X: Circular RNA circ-BNC2 (hsa_ circ_0008732) inhibits the progression of ovarian cancer through microRNA-223-3p/FBXW7 axis. J Ovarian Res. 15:952022. View Article : Google Scholar

50 

Xu Q, Deng B, Li M, Chen Y and Zhuan L: circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis. J Ovarian Res. 13:812020. View Article : Google Scholar : PubMed/NCBI

51 

Li M, Chi C, Zhou L, Chen Y and Tang X: Circular PVT1 regulates cell proliferation and invasion via miR-149-5p/FOXM1 axis in ovarian cancer. J Cancer. 12:611–621. 2021. View Article : Google Scholar : PubMed/NCBI

52 

Liang Y, Meng K and Qiu R: Circular RNA Circ_0013958 functions as a tumor promoter in ovarian cancer by regulating miR-637/PLXNB2 axis. Front Genet. 12:6444512021. View Article : Google Scholar : PubMed/NCBI

53 

Yu W, Goncalves KA, Li S, Kishikawa H, Sun G, Yang H, Vanli N, Wu Y, Jiang Y, Hu MG, et al: Plexin-B2 mediates physiologic and pathologic functions of angiogenin. Cell. 171:849–864.e25. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Li X, He S and Ma B: Autophagy and autophagy-related proteins in cancer. Mol Cancer. 19:122020. View Article : Google Scholar : PubMed/NCBI

55 

Wang Y, Mo Y, Peng M, Zhang S, Gong Z, Yan Q, Tang Y, He Y, Liao Q, Li X, et al: The influence of circular RNAs on autophagy and disease progression. Autophagy. 18:240–253. 2022. View Article : Google Scholar :

56 

Zhang Z, Zhu H and Hu J: CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129. Cell Death Dis. 12:2192021. View Article : Google Scholar : PubMed/NCBI

57 

Gan X, Zhu H, Jiang X, Obiegbusi SC, Yong M, Long X and Hu J: CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a. Mol Cancer. 19:452020. View Article : Google Scholar : PubMed/NCBI

58 

Song W, Zeng Z, Zhang Y, Li H, Cheng H, Wang J and Wu F: CircRNF144B/miR-342-3p/FBXL11 axis reduced autophagy and promoted the progression of ovarian cancer by increasing the ubiquitination of Beclin-1. Cell Death Dis. 13:8572022. View Article : Google Scholar : PubMed/NCBI

59 

Claesson-Welsh L and Welsh M: Vegfa and tumour angiogenesis. J Intern Med. 273:114–127. 2013. View Article : Google Scholar

60 

Wang J, Li Y, Zhou JH, Shen FR, Shi X and Chen YG: CircATRNL1 activates Smad4 signaling to inhibit angiogenesis and ovarian cancer metastasis via miR-378. Mol Oncol. 15:1217–1233. 2021. View Article : Google Scholar :

61 

Schwarte-Waldhoff I and Schmiegel W: Smad4 transcriptional pathways and angiogenesis. Int J Gastrointest Cancer. 31:47–59. 2002. View Article : Google Scholar

62 

Chen J, Li X, Yang L, Li M, Zhang Y and Zhang J: CircASH2L promotes ovarian cancer tumorigenesis, angiogenesis, and lymphangiogenesis by regulating the miR-665/VEGFA axis as a competing endogenous RNA. Front Cell Dev Biol. 8:5955852020. View Article : Google Scholar : PubMed/NCBI

63 

Ma L, Liu W and Li M: Circ_0061140 contributes to ovarian cancer progression by targeting miR-761/LETM1 signaling. Biochem Genet. 61:628–650. 2023. View Article : Google Scholar

64 

Pastushenko I and Blanpain C: EMT transition states during tumor progression and metastasis. Trends Cell Biol. 29:212–226. 2019. View Article : Google Scholar

65 

Shang BQ, Li ML, Quan HY, Hou PF, Li ZW, Chu SF, Zheng JN and Bai J: Functional roles of circular RNAs during epithelial-to-mesenchymal transition. Mol Cancer. 18:1382019. View Article : Google Scholar : PubMed/NCBI

66 

Zhang L, Zhou Q, Qiu Q, Hou L, Wu M, Li J, Li X, Lu B, Cheng X, Liu P, et al: CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer. Mol Cancer. 18:1442019. View Article : Google Scholar : PubMed/NCBI

67 

Bai F, Zhang LH, Liu X, Wang C, Zheng C, Sun J, Li M, Zhu WG and Pei XH: GATA3 functions downstream of BRCA1 to suppress EMT in breast cancer. Theranostics. 11:8218–8233. 2021. View Article : Google Scholar : PubMed/NCBI

68 

Menezes ME, Mitra A, Shevde LA and Samant RS: DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity. Biochem J. 444:573–580. 2012. View Article : Google Scholar : PubMed/NCBI

69 

Tiwari N, Meyer-Schaller N, Arnold P, Antoniadis H, Pachkov M, van Nimwegen E and Christofori G: Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8). PLoS One. 8:e573292013. View Article : Google Scholar : PubMed/NCBI

70 

Zeng XY, Yuan J, Wang C, Zeng D, Yong JH, Jiang XY, Lan H and Xiao SS: circCELSR1 facilitates ovarian cancer proliferation and metastasis by sponging miR-598 to activate BRD4 signals. Mol Med. 26:702020. View Article : Google Scholar : PubMed/NCBI

71 

Li X, Lin S, Mo Z, Jiang J, Tang H, Wu C and Song J: CircRNA_100395 inhibits cell proliferation and metastasis in ovarian cancer via regulating miR-1228/p53/epithelial-mesenchymal transition (EMT) axis. J Cancer. 11:599–609. 2020. View Article : Google Scholar : PubMed/NCBI

72 

Zhou J, Dong ZN, Qiu BQ, Hu M, Liang XQ, Dai X, Hong D and Sun YF: CircRNA FGFR3 induces epithelial-mesenchymal transition of ovarian cancer by regulating miR-29a-3p/E2F1 axis. Aging (Albany NY). 12:14080–14091. 2020. View Article : Google Scholar : PubMed/NCBI

73 

Wu SG, Zhou P, Chen JX, Lei J, Hua L, Dong Y, Hu M, Lian CL, Yang LC and Zhou J: circ-PTK2 (hsa_circ_0008305) regulates the pathogenic processes of ovarian cancer via miR-639 and FOXC1 regulatory cascade. Cancer Cell Int. 21:2772021. View Article : Google Scholar : PubMed/NCBI

74 

Zhang F, Xu Y, Ye W, Jiang J and Wu C: Circular RNA S-7 promotes ovarian cancer EMT via sponging miR-641 to up-regulate ZEB1 and MDM2. Biosci Rep. 40:BSR202008252020. View Article : Google Scholar : PubMed/NCBI

75 

Chen Q, Zhang J, He Y and Wang Y: hsa_circ_0061140 knockdown reverses FOXM1-mediated cell growth and metastasis in ovarian cancer through miR-370 sponge activity. Mol Ther Nucleic Acids. 13:55–63. 2018. View Article : Google Scholar : PubMed/NCBI

76 

Wang T, Chen X, Qiao W, Kong L, Sun D and Li Z: Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer. BMC Cancer. 17:7192017. View Article : Google Scholar : PubMed/NCBI

77 

Li Y and Chen X: miR-4792 inhibits epithelial-mesenchymal transition and invasion in nasopharyngeal carcinoma by targeting FOXC1. Biochem Biophys Res Commun. 468:863–869. 2015. View Article : Google Scholar : PubMed/NCBI

78 

Caramel J, Ligier M and Puisieux A: Pleiotropic roles for ZEB1 in cancer. Cancer Res. 78:30–35. 2018. View Article : Google Scholar

79 

Katoh M, Igarashi M, Fukuda H, Nakagama H and Katoh M: Cancer genetics and genomics of human FOX family genes. Cancer Lett. 328:198–206. 2013. View Article : Google Scholar

80 

Wang Y and Patti GJ: The Warburg effect: A signature of mitochondrial overload. Trends Cell Boil. 33:1014–1020. 2023. View Article : Google Scholar

81 

Yu G, Yang Z, Peng T and Lv Y: Circular RNAs: Rising stars in lipid metabolism and lipid disorders. J Cell Physiol. 236:4797–4806. 2021. View Article : Google Scholar

82 

Yu T, Wang Y, Fan Y, Fang N, Wang T, Xu T and Shu Y: CircRNAs in cancer metabolism: A review. J Hematol Oncol. 12:902019. View Article : Google Scholar : PubMed/NCBI

83 

Lin C, Xu X, Yang Q, Liang L and Qiao S: Circular RNA ITCH suppresses proliferation, invasion, and glycolysis of ovarian cancer cells by up-regulating CDH1 via sponging miR-106a. Cancer Cell Int. 20:3362020. View Article : Google Scholar : PubMed/NCBI

84 

Xie W, Liu LU, He C, Zhao M, Ni R, Zhang Z and Shui C: Circ_0002711 knockdown suppresses cell growth and aerobic glycolysis by modulating miR-1244/ROCK1 axis in ovarian cancer. J Biosci. 46:212021. View Article : Google Scholar : PubMed/NCBI

85 

Hou W and Zhang Y: Circ_0025033 promotes the progression of ovarian cancer by activating the expression of LSM4 via targeting miR-184. Pathol Res Pract. 217:1532752021. View Article : Google Scholar

86 

Chen L, Lin YH, Liu GQ, Huang JE, Wei W, Yang ZH, Hu YM, Xie JH and Yu HZ: Clinical significance and potential role of LSM4 overexpression in hepatocellular carcinoma: An integrated analysis based on multiple databases. Front Genet. 12:8049162022. View Article : Google Scholar : PubMed/NCBI

87 

Ma H, Qu S, Zhai Y and Yang X: circ_0025033 promotes ovarian cancer development via regulating the hsa_miR-370-3p/SLC1A5 axis. Cell Mol Biol Lett. 27:942022. View Article : Google Scholar : PubMed/NCBI

88 

Chen Y, Ye X, Xia X and Lin X: Circular RNA ABCB10 correlates with advanced clinicopathological features and unfavorable survival, and promotes cell proliferation while reduces cell apoptosis in epithelial ovarian cancer. Cancer Biomark. 26:151–161. 2019. View Article : Google Scholar : PubMed/NCBI

89 

Hu Y, Zhu Y, Zhang W, Lang J and Ning L: Utility of plasma circBNC2 as a diagnostic biomarker in epithelial ovarian cancer. Onco Targets Ther. 12:9715–9723. 2019. View Article : Google Scholar

90 

Ning L, Lang J and Wu L: Plasma circN4BP2L2 is a promising novel diagnostic biomarker for epithelial ovarian cancer. BMC Cancer. 22:62022. View Article : Google Scholar : PubMed/NCBI

91 

Wang S, Zhang K, Tan S, Xin J, Yuan Q, Xu H, Xu X, Liang Q, Christiani DC, Wang M, et al: Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies. Mol Cancer. 20:132021. View Article : Google Scholar : PubMed/NCBI

92 

Zheng Y, Li Z, Yang S, Wang Y and Luan Z: CircEXOC6B suppresses the proliferation and motility and sensitizes ovarian cancer cells to paclitaxel through miR-376c-3p/FOXO3 axis. Cancer Biother Radiopharm. 37:802–814. 2022.

93 

Zhu J, Luo JE, Chen Y and Wu Q: Circ_0061140 knockdown inhibits tumorigenesis and improves PTX sensitivity by regulating miR-136/CBX2 axis in ovarian cancer. J Ovarian Res. 14:1362021. View Article : Google Scholar : PubMed/NCBI

94 

Huang H, Yan L, Zhong J, Hong L, Zhang N and Luo X: Circ_0025033 deficiency suppresses paclitaxel resistance and malignant development of paclitaxel-resistant ovarian cancer cells by modulating the miR-532-3p/FOXM1 network. Immunopharmacol Immunotoxicol. 44:275–286. 2022. View Article : Google Scholar : PubMed/NCBI

95 

Xia B, Zhao Z, Wu Y, Wang Y, Zhao Y and Wang J: Circular RNA circTNPO3 regulates paclitaxel resistance of ovarian cancer cells by miR-1299/NEK2 signaling pathway. Mol Ther Nucleic Acids. 21:780–791. 2020. View Article : Google Scholar : PubMed/NCBI

96 

Yuan D, Guo T, Qian H, Ge H, Zhao Y, Huang A, Wang X, Cao X, Zhu D, He C and Yu H: Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis. Drug Dev Res. 83:1383–1393. 2022. View Article : Google Scholar : PubMed/NCBI

97 

Luo Y and Gui R: Circulating exosomal circFoxp1 confers cisplatin resistance in epithelial ovarian cancer cells. J Gynecol Oncol. 31:e752020. View Article : Google Scholar : PubMed/NCBI

98 

Liu X, Yin Z, Wu Y, Zhan Q, Huang H and Fan J: Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer. Bioengineered. 13:3739–3750. 2022. View Article : Google Scholar : PubMed/NCBI

99 

Cheng Y, Ban R, Liu W, Wang H, Li S, Yue Z, Zhu G, Zhuan Y and Wang C: MiRNA-409-3p enhances cisplatin-sensitivity of ovarian cancer cells by blocking the autophagy mediated by Fip200. Oncol Res. Jan 2–2018.Epub ahead of print. View Article : Google Scholar

100 

Ghafouri-Fard S, Khoshbakht T, Bahranian A, Taheri M and Hallajnejad M: CircMTO1: A circular RNA with roles in the carcinogenesis. Biomed Pharmacother. 142:1120252021. View Article : Google Scholar : PubMed/NCBI

101 

Wang J, Wu A, Yang B, Zhu X, Teng Y and Ai Z: Profiling and bioinformatics analyses reveal differential circular RNA expression in ovarian cancer. Gene. 724:1441502020. View Article : Google Scholar

102 

Zhang PF, Gao C, Huang XY, Lu JC, Guo XJ, Shi GM, Cai JB and Ke AW: Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma. Mol Cancer. 19:1102020. View Article : Google Scholar : PubMed/NCBI

103 

Gong J, Xu X, Zhang X and Zhou Y: Circular RNA-9119 suppresses in ovarian cancer cell viability via targeting the microRNA-21-5p-PTEN-Akt pathway. Aging (Albany NY). 12:14314–14328. 2020. View Article : Google Scholar : PubMed/NCBI

104 

Guo M, Li S, Zhao X, Yuan Y, Zhang B and Guan Y: Knockdown of circular RNA Hsa_circ_0000714 can regulate RAB17 by sponging miR-370-3p to reduce paclitaxel resistance of ovarian cancer through CDK6/RB pathway. Onco Targets Ther. 13:13211–13224. 2020. View Article : Google Scholar :

105 

Ji J, Li C, Wang J, Wang L, Huang H, Li Y and Fang J: Hsa_circ_0001756 promotes ovarian cancer progression through regulating IGF2BP2-mediated RAB5A expression and the EGFR/MAPK signaling pathway. Cell Cycle. 21:685–696. 2022. View Article : Google Scholar : PubMed/NCBI

106 

Zhang C, Li Y, Zhao W, Liu G and Yang Q: Circ-PGAM1 promotes malignant progression of epithelial ovarian cancer through regulation of the miR-542-3p/CDC5L/PEAK1 pathway. Cancer Med. 9:3500–3521. 2020. View Article : Google Scholar : PubMed/NCBI

107 

He SL, Zhao X and Yi SJ: CircAHNAK upregulates EIF2B5 expression to inhibit the progression of ovarian cancer by modulating the JAK2/STAT3 signaling pathway. Carcinogenesis. 43:941–955. 2022. View Article : Google Scholar : PubMed/NCBI

108 

Lu H, Zheng G, Gao X, Chen C, Zhou M and Zhang L: Propofol suppresses cell viability, cell cycle progression and motility and induces cell apoptosis of ovarian cancer cells through suppressing MEK/ERK signaling via targeting circVPS13C/miR-145 axis. J Ovarian Res. 14:302021. View Article : Google Scholar : PubMed/NCBI

109 

Fu Z, Ding C, Gong W and Lu C: ncRNAs mediated RPS6KA2 inhibits ovarian cancer proliferation via p38/MAPK signaling pathway. Front Oncol. 13:10283012023. View Article : Google Scholar : PubMed/NCBI

110 

Wang S, Li Z, Zhu G, Hong L, Hu C, Wang K, Cui K and Hao C: RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis. J Ovarian Res. 14:1542021. View Article : Google Scholar : PubMed/NCBI

111 

Wu M, Qiu Q, Zhou Q, Li J, Yang J, Zheng C, Luo A, Li X, Zhang H, Cheng X, et al: circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer. Mol Cancer. 21:1372022. View Article : Google Scholar : PubMed/NCBI

112 

Lin X, Chen Y, Ye X and Xia X: Circular RNA ABCB10 promotes cell proliferation and invasion, but inhibits apoptosis via regulating the microRNA-1271-mediated Capn4/Wnt/β-catenin signaling pathway in epithelial ovarian cancer. Mol Med Rep. 23:3872021. View Article : Google Scholar

113 

Wu Y, Zhou J, Li Y, Shi X, Shen F, Chen M, Chen Y and Wang J: Hsa_circ_0001445 works as a cancer suppressor via miR-576-5p/SFRP1 axis regulation in ovarian cancer. Cancer Med. 12:5736–5750. 2023. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ye W, Xiang N, Wang Q and Lu Y: Role of circular RNA as competing endogenous RNA in ovarian cancer (Review). Int J Mol Med 53: 41, 2024.
APA
Ye, W., Xiang, N., Wang, Q., & Lu, Y. (2024). Role of circular RNA as competing endogenous RNA in ovarian cancer (Review). International Journal of Molecular Medicine, 53, 41. https://doi.org/10.3892/ijmm.2024.5365
MLA
Ye, W., Xiang, N., Wang, Q., Lu, Y."Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)". International Journal of Molecular Medicine 53.5 (2024): 41.
Chicago
Ye, W., Xiang, N., Wang, Q., Lu, Y."Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)". International Journal of Molecular Medicine 53, no. 5 (2024): 41. https://doi.org/10.3892/ijmm.2024.5365
Copy and paste a formatted citation
x
Spandidos Publications style
Ye W, Xiang N, Wang Q and Lu Y: Role of circular RNA as competing endogenous RNA in ovarian cancer (Review). Int J Mol Med 53: 41, 2024.
APA
Ye, W., Xiang, N., Wang, Q., & Lu, Y. (2024). Role of circular RNA as competing endogenous RNA in ovarian cancer (Review). International Journal of Molecular Medicine, 53, 41. https://doi.org/10.3892/ijmm.2024.5365
MLA
Ye, W., Xiang, N., Wang, Q., Lu, Y."Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)". International Journal of Molecular Medicine 53.5 (2024): 41.
Chicago
Ye, W., Xiang, N., Wang, Q., Lu, Y."Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)". International Journal of Molecular Medicine 53, no. 5 (2024): 41. https://doi.org/10.3892/ijmm.2024.5365
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