Open Access

Obesity and lipid metabolism in the development of osteoporosis (Review)

  • Authors:
    • Xiaochuan Wang
    • Chi Zhang
    • Guang Zhao
    • Keda Yang
    • Lin Tao
  • View Affiliations

  • Published online on: May 27, 2024     https://doi.org/10.3892/ijmm.2024.5385
  • Article Number: 61
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoporosis is a common bone metabolic disease that causes a heavy social burden and seriously threatens life. Improving osteogenic capacity is necessary to correct bone mass loss in the treatment of osteoporosis. Osteoblasts are derived from the differentiation of bone marrow mesenchymal stem cells, a process that opposes adipogenic differentiation. The peroxisome proliferator‑activated receptor γ and Wnt/β‑catenin signaling pathways mediate the mutual regulation of osteogenesis and adipogenesis. Lipid substances play an important role in the occurrence and development of osteoporosis. The content and proportion of lipids modulate the activity of immunocytes, mainly macrophages, and the secretion of inflammatory factors, such as IL‑1, IL‑6 and TNF‑α. These inflammatory effectors increase the activity and promote the differentiation of osteoclasts, which leads to bone imbalance and stronger bone resorption. Obesity also decreases the activity of antioxidases and leads to oxidative stress, thereby inhibiting osteogenesis. The present review starts by examining the bidirectional differentiation of BM‑MSCs, describes in detail the mechanism by which lipids affect bone metabolism, and discusses the regulatory role of inflammation and oxidative stress in this process. The review concludes that a reasonable adjustment of the content and proportion of lipids, and the alleviation of inflammatory storms and oxidative damage induced by lipid imbalances, will improve bone mass and treat osteoporosis.

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July-2024
Volume 54 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Wang X, Zhang C, Zhao G, Yang K and Tao L: Obesity and lipid metabolism in the development of osteoporosis (Review). Int J Mol Med 54: 61, 2024
APA
Wang, X., Zhang, C., Zhao, G., Yang, K., & Tao, L. (2024). Obesity and lipid metabolism in the development of osteoporosis (Review). International Journal of Molecular Medicine, 54, 61. https://doi.org/10.3892/ijmm.2024.5385
MLA
Wang, X., Zhang, C., Zhao, G., Yang, K., Tao, L."Obesity and lipid metabolism in the development of osteoporosis (Review)". International Journal of Molecular Medicine 54.1 (2024): 61.
Chicago
Wang, X., Zhang, C., Zhao, G., Yang, K., Tao, L."Obesity and lipid metabolism in the development of osteoporosis (Review)". International Journal of Molecular Medicine 54, no. 1 (2024): 61. https://doi.org/10.3892/ijmm.2024.5385