Open Access

Metformin prevents the onset and progression of intervertebral disc degeneration: New insights and potential mechanisms (Review)

  • Authors:
    • Wenzhi Yang
    • Yipin Yang
    • Yong Wang
    • Zongshi Gao
    • Jingtang Zhang
    • Weimin Gao
    • Yanjun Chen
    • You Lu
    • Haoyu Wang
    • Lingyan Zhou
    • Yifan Wang
    • Jie Li
    • Hui Tao
  • View Affiliations

  • Published online on: July 2, 2024     https://doi.org/10.3892/ijmm.2024.5395
  • Article Number: 71
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Metformin has been the go‑to medical treatment for addressing type 2 diabetes mellitus (T2DM) as a frontline oral antidiabetic. Obesity, cancer and bone deterioration are linked to T2DM, which is considered a metabolic illness. Numerous diseases associated with T2DM, such as tumours, cardiovascular disease and bone deterioration, may be treated with metformin. Intervertebral disc degeneration (IVDD) is distinguished by degeneration of the spinal disc, accompanied by the gradual depletion of proteoglycans and water in the nucleus pulposus (NP) of the IVD, resulting in lower back pain. The therapeutic effect of metformin on IVDD has also attracted much attention. By stimulating AMP‑activated kinase, metformin could enhance autophagy and suppress cell senescence, apoptosis and inflammation, thus effectively delaying IVDD. The present review aimed to systematically explain the development of IVDD and mechanism of metformin in the treatment and prevention of IVDD to provide a reference for the clinical application of metformin as adjuvant therapy in the treatment of IVDD.
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August-2024
Volume 54 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Yang W, Yang Y, Wang Y, Gao Z, Zhang J, Gao W, Chen Y, Lu Y, Wang H, Zhou L, Zhou L, et al: Metformin prevents the onset and progression of intervertebral disc degeneration: New insights and potential mechanisms (Review). Int J Mol Med 54: 71, 2024
APA
Yang, W., Yang, Y., Wang, Y., Gao, Z., Zhang, J., Gao, W. ... Tao, H. (2024). Metformin prevents the onset and progression of intervertebral disc degeneration: New insights and potential mechanisms (Review). International Journal of Molecular Medicine, 54, 71. https://doi.org/10.3892/ijmm.2024.5395
MLA
Yang, W., Yang, Y., Wang, Y., Gao, Z., Zhang, J., Gao, W., Chen, Y., Lu, Y., Wang, H., Zhou, L., Wang, Y., Li, J., Tao, H."Metformin prevents the onset and progression of intervertebral disc degeneration: New insights and potential mechanisms (Review)". International Journal of Molecular Medicine 54.2 (2024): 71.
Chicago
Yang, W., Yang, Y., Wang, Y., Gao, Z., Zhang, J., Gao, W., Chen, Y., Lu, Y., Wang, H., Zhou, L., Wang, Y., Li, J., Tao, H."Metformin prevents the onset and progression of intervertebral disc degeneration: New insights and potential mechanisms (Review)". International Journal of Molecular Medicine 54, no. 2 (2024): 71. https://doi.org/10.3892/ijmm.2024.5395