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Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review)

  • Authors:
    • Qihang Yan
    • Wingshing Wong
    • Li Gong
    • Jie Yang
    • Dachuan Liang
    • Kok-Yong Chin
    • Shuqin Dai
    • Junye Wang
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat‑sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China, Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras 56000, Malaysia
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 72
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    Published online on: July 2, 2024
       https://doi.org/10.3892/ijmm.2024.5396
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Abstract

Esophageal squamous cell carcinoma (ESCC) is a prevalent and deadly malignancy of the digestive tract. Recent research has identified long non‑coding RNAs (lncRNAs) as crucial regulators in the pathogenesis of ESCC. These lncRNAs, typically exceeding 200 nucleotides, modulate gene expression through various mechanisms, including the competing endogenous RNA (ceRNA) pathway and RNA‑protein interactions. The current study reviews the multifaceted roles of lncRNAs in ESCC, highlighting their involvement in processes such as proliferation, migration, invasion, epithelial‑mesenchymal transition, cell cycle progression, resistance to radiotherapy and chemotherapy, glycolysis, apoptosis, angiogenesis, autophagy, tumor growth, metastasis and the maintenance of cancer stem cells. Specific lncRNAs like HLA complex P5, LINC00963 and non‑coding repressor of NFAT have been shown to enhance resistance to radio‑ and chemotherapy by modulating pathways such as AKT signaling and microRNA interaction, which promote cell survival and proliferation under therapeutic stress. Furthermore, lncRNAs like family with sequence similarity 83, member A antisense RNA 1, zinc finger NFX1‑type containing 1 antisense RNA 1 and taurine upregulated gene 1 are implicated in enhancing invasive and proliferative capabilities of ESCC cells through the ceRNA mechanism, while interactions with RNA‑binding proteins further influence cancer cell behavior. The comprehensive analysis underscores the potential of lncRNAs as biomarkers for prognosis and therapeutic targets in ESCC, suggesting avenues for future research focused on elucidating the detailed molecular mechanisms and clinical applications of lncRNAs in ESCC management.
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Yan Q, Wong W, Gong L, Yang J, Liang D, Chin K, Dai S and Wang J: Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review). Int J Mol Med 54: 72, 2024.
APA
Yan, Q., Wong, W., Gong, L., Yang, J., Liang, D., Chin, K. ... Wang, J. (2024). Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review). International Journal of Molecular Medicine, 54, 72. https://doi.org/10.3892/ijmm.2024.5396
MLA
Yan, Q., Wong, W., Gong, L., Yang, J., Liang, D., Chin, K., Dai, S., Wang, J."Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review)". International Journal of Molecular Medicine 54.2 (2024): 72.
Chicago
Yan, Q., Wong, W., Gong, L., Yang, J., Liang, D., Chin, K., Dai, S., Wang, J."Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review)". International Journal of Molecular Medicine 54, no. 2 (2024): 72. https://doi.org/10.3892/ijmm.2024.5396
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Spandidos Publications style
Yan Q, Wong W, Gong L, Yang J, Liang D, Chin K, Dai S and Wang J: Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review). Int J Mol Med 54: 72, 2024.
APA
Yan, Q., Wong, W., Gong, L., Yang, J., Liang, D., Chin, K. ... Wang, J. (2024). Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review). International Journal of Molecular Medicine, 54, 72. https://doi.org/10.3892/ijmm.2024.5396
MLA
Yan, Q., Wong, W., Gong, L., Yang, J., Liang, D., Chin, K., Dai, S., Wang, J."Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review)". International Journal of Molecular Medicine 54.2 (2024): 72.
Chicago
Yan, Q., Wong, W., Gong, L., Yang, J., Liang, D., Chin, K., Dai, S., Wang, J."Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review)". International Journal of Molecular Medicine 54, no. 2 (2024): 72. https://doi.org/10.3892/ijmm.2024.5396
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