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Role of autophagy and ferroptosis in the development of endometriotic cysts (Review)

  • Authors:
    • Hiroshi Kobayashi
    • Shogo Imanaka
    • Chiharu Yoshimoto
    • Sho Matsubara
    • Hiroshi Shigetomi
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, Kashihara, Nara 634‑0813, Japan, Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara 634‑8522, Japan
    Copyright: © Kobayashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 78
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    Published online on: July 11, 2024
       https://doi.org/10.3892/ijmm.2024.5402
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Abstract

It is considered that the etiology of endometriosis is retrograde menstruation of endometrial tissue. Although shed endometrial cells are constantly exposed to a challenging environment with iron overload, oxidative stress and hypoxia, a few cells are able to survive and continue to proliferate and invade. Ferroptosis, an iron‑dependent form of non‑apoptotic cell death, is known to play a major role in the development and course of endometriosis. However, few papers have concentrated on the dynamic interaction between autophagy and ferroptosis throughout the progression of diseases. The present review summarized the current understanding of the mechanisms underlying autophagy and ferroptosis in endometriosis and discuss their role in disease development and progression. For the present narrative review electronic databases including PubMed and Google Scholar were searched for literature published up to the October 31, 2023. Autophagy and ferroptosis may be activated at early stages in endometriosis development. On the other hand, excessive activation of intrinsic pathways (e.g., estrogen and mechanistic target of rapamycin) may promote disease progression through autophagy inhibition. Furthermore, suppression of ferroptosis may cause further progression of endometriotic lesions. In conclusion, the autophagy and ferroptosis pathways may play a dual role in disease initiation and progression. The present review discussed the temporal transition of non‑apoptotic cell death regulation during disease progression from retrograde endometrium to early lesions to established lesions.
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Copy and paste a formatted citation
Spandidos Publications style
Kobayashi H, Imanaka S, Yoshimoto C, Matsubara S and Shigetomi H: Role of autophagy and ferroptosis in the development of endometriotic cysts (Review). Int J Mol Med 54: 78, 2024.
APA
Kobayashi, H., Imanaka, S., Yoshimoto, C., Matsubara, S., & Shigetomi, H. (2024). Role of autophagy and ferroptosis in the development of endometriotic cysts (Review). International Journal of Molecular Medicine, 54, 78. https://doi.org/10.3892/ijmm.2024.5402
MLA
Kobayashi, H., Imanaka, S., Yoshimoto, C., Matsubara, S., Shigetomi, H."Role of autophagy and ferroptosis in the development of endometriotic cysts (Review)". International Journal of Molecular Medicine 54.3 (2024): 78.
Chicago
Kobayashi, H., Imanaka, S., Yoshimoto, C., Matsubara, S., Shigetomi, H."Role of autophagy and ferroptosis in the development of endometriotic cysts (Review)". International Journal of Molecular Medicine 54, no. 3 (2024): 78. https://doi.org/10.3892/ijmm.2024.5402
Copy and paste a formatted citation
x
Spandidos Publications style
Kobayashi H, Imanaka S, Yoshimoto C, Matsubara S and Shigetomi H: Role of autophagy and ferroptosis in the development of endometriotic cysts (Review). Int J Mol Med 54: 78, 2024.
APA
Kobayashi, H., Imanaka, S., Yoshimoto, C., Matsubara, S., & Shigetomi, H. (2024). Role of autophagy and ferroptosis in the development of endometriotic cysts (Review). International Journal of Molecular Medicine, 54, 78. https://doi.org/10.3892/ijmm.2024.5402
MLA
Kobayashi, H., Imanaka, S., Yoshimoto, C., Matsubara, S., Shigetomi, H."Role of autophagy and ferroptosis in the development of endometriotic cysts (Review)". International Journal of Molecular Medicine 54.3 (2024): 78.
Chicago
Kobayashi, H., Imanaka, S., Yoshimoto, C., Matsubara, S., Shigetomi, H."Role of autophagy and ferroptosis in the development of endometriotic cysts (Review)". International Journal of Molecular Medicine 54, no. 3 (2024): 78. https://doi.org/10.3892/ijmm.2024.5402
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