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Review Open Access

Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review)

  • Authors:
    • Xiang Li
    • Yuan Xu
    • Jing-Xing Si
    • Fang Gu
    • Ying-Yu Ma
  • View Affiliations / Copyright

    Affiliations: Center for Plastic and Reconstructive Surgery, Department of Plastic and Reconstructive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China, Department of Gastrointestinal Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang 315048, P.R. China, Department of Paediatrics, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 98
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    Published online on: September 11, 2024
       https://doi.org/10.3892/ijmm.2024.5422
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Abstract

Tissue regeneration is a complex process that involves the recruitment of various types of cells for healing after injury; it is mediated by numerous precise interactions. However, the identification of effective targets for improving tissue regeneration remains a challenge. As an extracellular matrix protein, Agrin plays a critical role in neuromuscular junction formation. Furthermore, recent studies have revealed the role of Agrin in regulating tissue proliferation and regeneration, which contributes to the repair process of injured tissues. An in‑depth understanding of the role of Agrin will therefore be of value. Given that repair and regeneration processes occur in various parts of the human body, the present systematic review focuses on the role of Agrin in typical tissue and highlights the potential signaling pathways that are involved in Agrin‑induced repair and regeneration. This review offers important insight into novel strategies for the future clinical applications of Agrin‑based therapies, which may represent a feasible treatment option for patients who require organ replacement or repair.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Xu Y, Si J, Gu F and Ma Y: Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review). Int J Mol Med 54: 98, 2024.
APA
Li, X., Xu, Y., Si, J., Gu, F., & Ma, Y. (2024). Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review). International Journal of Molecular Medicine, 54, 98. https://doi.org/10.3892/ijmm.2024.5422
MLA
Li, X., Xu, Y., Si, J., Gu, F., Ma, Y."Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review)". International Journal of Molecular Medicine 54.5 (2024): 98.
Chicago
Li, X., Xu, Y., Si, J., Gu, F., Ma, Y."Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review)". International Journal of Molecular Medicine 54, no. 5 (2024): 98. https://doi.org/10.3892/ijmm.2024.5422
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Xu Y, Si J, Gu F and Ma Y: Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review). Int J Mol Med 54: 98, 2024.
APA
Li, X., Xu, Y., Si, J., Gu, F., & Ma, Y. (2024). Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review). International Journal of Molecular Medicine, 54, 98. https://doi.org/10.3892/ijmm.2024.5422
MLA
Li, X., Xu, Y., Si, J., Gu, F., Ma, Y."Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review)". International Journal of Molecular Medicine 54.5 (2024): 98.
Chicago
Li, X., Xu, Y., Si, J., Gu, F., Ma, Y."Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review)". International Journal of Molecular Medicine 54, no. 5 (2024): 98. https://doi.org/10.3892/ijmm.2024.5422
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