From banked human cord blood to induced pluripotent stem cells: New opportunities and promise in induced pluripotent stem cell banking (Review)

  • Authors:
    • Fatin Fazrina Roslan
    • Yuexin Yu
    • Ghee Chien Ooi
    • Khong Lek Then
    • Kong Yong Then
    • Soon-Keng Cheong
    • Zhikun Guo
    • Mohd Nor Azim Ab Patar
    • Jun Jie Tan
  • View Affiliations

  • Published online on: October 14, 2024     https://doi.org/10.3892/ijmm.2024.5438
  • Article Number: 114
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Umbilical cord blood (CB) is a valuable source of haematopoietic stem/progenitor cells (HSCs) and is known for the therapeutic use of these cells in treating blood disorders. However, challenges such as a high running cost and the increasing availability of treatment alternatives have made the effort to sustain CB banks difficult. This prompts the need to revisit the current CB banking initiatives to retain the relevance in this ever‑changing era parallel to the fast‑pacing development of cell‑based therapeutic technology. Cellular reprogramming has shown to have successfully converted adult somatic cells into human induced pluripotent stem cells (hiPSCs), which promise wider applications in regenerative medicine, personalized treatment and tissue engineering. CB is the youngest, primitive adult cell source that has not been affected by any prior, acquired disorders. Hence, using CB as a source of candidate cells for generating hiPSCs may be a new opportunity for banking, albeit with challenges. The present review summarizes the rise and fall of CB usage and banking for clinical therapy, the considerations in reprogramming CB into hiPSCs, the safety concerns regarding the use of hiPSC‑derived cells in clinical transplantation and the prospect of using CB‑derived hiPSCs.
View References

Related Articles

Journal Cover

December-2024
Volume 54 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Roslan F, Yu Y, Ooi G, Then KL, Then K, Cheong S, Guo Z, Ab Patar M and Tan J: From banked human cord blood to induced pluripotent stem cells: New opportunities and promise in induced pluripotent stem cell banking (Review). Int J Mol Med 54: 114, 2024.
APA
Roslan, F., Yu, Y., Ooi, G., Then, K.L., Then, K., Cheong, S. ... Tan, J. (2024). From banked human cord blood to induced pluripotent stem cells: New opportunities and promise in induced pluripotent stem cell banking (Review). International Journal of Molecular Medicine, 54, 114. https://doi.org/10.3892/ijmm.2024.5438
MLA
Roslan, F., Yu, Y., Ooi, G., Then, K. L., Then, K., Cheong, S., Guo, Z., Ab Patar, M., Tan, J."From banked human cord blood to induced pluripotent stem cells: New opportunities and promise in induced pluripotent stem cell banking (Review)". International Journal of Molecular Medicine 54.6 (2024): 114.
Chicago
Roslan, F., Yu, Y., Ooi, G., Then, K. L., Then, K., Cheong, S., Guo, Z., Ab Patar, M., Tan, J."From banked human cord blood to induced pluripotent stem cells: New opportunities and promise in induced pluripotent stem cell banking (Review)". International Journal of Molecular Medicine 54, no. 6 (2024): 114. https://doi.org/10.3892/ijmm.2024.5438