Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
January-2025 Volume 55 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2025 Volume 55 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway

  • Authors:
    • Yutong Sun
    • Chunyang Wang
    • Liling Wen
    • Zihang Ling
    • Juan Xia
    • Bin Cheng
    • Jianmin Peng
  • View Affiliations / Copyright

    Affiliations: Hospital of Stomatology, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 4
    |
    Published online on: October 22, 2024
       https://doi.org/10.3892/ijmm.2024.5445
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cell senescence impedes the self‑renewal and osteogenic capacity of bone marrow mesenchymal stem cells (BMSCs), thus limiting their application in tissue regeneration. The present study aimed to elucidate the role and mechanism of repetitive element (RE) activation in BMSC senescence and osteogenesis, as well as the intervention effect of quercetin. In an H2O2‑induced BMSC senescence model, quercetin treatment alleviated senescence as shown by a decrease in senescence‑associated β‑galactosidase (SA‑β‑gal)‑positive cell ratio, increased colony formation ability and decreased mRNA expression of p21 and senescence‑associated secretory phenotype genes. DNA damage response marker γ‑H2AX increased in senescent BMSCs, while expression of epigenetic markers methylation histone H3 Lys9, heterochromatin protein 1α and heterochromatin‑related nuclear membrane protein lamina‑associated polypeptide 2 decreased. Quercetin rescued these alterations, indicating its ability to ameliorate senescence by stabilizing heterochromatin structure where REs are primarily suppressed. Transcriptional activation of REs accompanied by accumulation of cytoplasmic double‑stranded (ds)RNA, as well as triggering of the RNA sensor retinoic acid‑inducible gene I (RIG‑I) receptor pathway in H2O2‑induced senescent BMSCs were shown. Similarly, quercetin treatment inhibited these responses. Additionally, RIG‑I knockdown led to a decreased number of SA‑β‑gal‑positive cells, confirming its functional impact on senescence. Induction of senescence or administration of dsRNA analogue significantly hindered the osteogenic capacity of BMSCs, while quercetin treatment or RIG‑I knockdown reversed the decline in osteogenic function. The findings of the current study demonstrated that quercetin inhibited the activation of REs and the RIG‑I RNA sensing pathway via epigenetic regulation, thereby alleviating the senescence of BMSCs and promoting osteogenesis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Zheng C, Chen J, Liu S and Jin Y: Stem cell-based bone and dental regeneration: A view of microenvironmental modulation. Int J Oral Sci. 11:232019. View Article : Google Scholar : PubMed/NCBI

2 

Al-Azab M, Safi M, Idiiatullina E, Al-Shaebi F and Zaky MY: Aging of mesenchymal stem cell: Machinery, markers, and strategies of fighting. Cell Mol Biol Lett. 27:692022. View Article : Google Scholar : PubMed/NCBI

3 

Lin H, Sohn J, Shen H, Langhans MT and Tuan RS: Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing. Biomaterials. 203:96–110. 2019. View Article : Google Scholar :

4 

Lopez-Otin C, Blasco MA, Partridge L, Serrano M and Kroemer G: The hallmarks of aging. Cell. 153:1194–1217. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, et al: Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 348:1160–1163. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Soto-Palma C, Niedernhofer LJ, Faulk CD and Dong X: Epigenetics, DNA damage, and aging. J Clin Invest. 132:e1584462022. View Article : Google Scholar : PubMed/NCBI

7 

Pathak RU, Soujanya M and Mishra RK: Deterioration of nuclear morphology and architecture: A hallmark of senescence and aging. Ageing Res Rev. 67:1012642021. View Article : Google Scholar : PubMed/NCBI

8 

Stamidis N and Żylicz JJ: RNA-mediated heterochromatin formation at repetitive elements in mammals. EMBO J. 42:e1117172023. View Article : Google Scholar : PubMed/NCBI

9 

McCarthy RL, Kaeding KE, Keller SH, Zhong Y, Xu L, Hsieh A, Hou Y, Donahue G, Becker JS, Alberto O, et al: Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements. Nat Cell Biol. 23:905–914. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Anwar SL, Wulaningsih W and Lehmann U: Transposable Elements in human cancer: Causes and consequences of deregulation. Int J Mol Sci. 18:9742017. View Article : Google Scholar : PubMed/NCBI

11 

Gorbunova V, Seluanov A, Mita P, McKerrow W, Fenyö D, Boeke JD, Linker SB, Gage FH, Kreiling JA, Petrashen AP, et al: The role of retrotransposable elements in ageing and age-associated diseases. Nature. 596:43–53. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Wang J, Lu X, Zhang W and Liu GH: Endogenous retroviruses in development and health. Trends Microbiol. 32:342–354. 2024. View Article : Google Scholar

13 

Ågren JA and Clark AG: Selfish genetic elements. PLoS Genet. 14:e10077002018. View Article : Google Scholar : PubMed/NCBI

14 

Huang CR, Burns KH and Boeke JD: Active transposition in genomes. Annu Rev Genet. 46:651–675. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Dumetier B, Sauter C, Hajmirza A, Pernon B, Aucagne R, Fournier C, Row C, Guidez F, Rossi C, Lepage C, et al: Repeat element activation-driven inflammation: Role of NFκB and implications in normal development and cancer? Biomedicines. 10:31012022. View Article : Google Scholar

16 

Lanciano S and Cristofari G: Measuring and interpreting transposable element expression. Nat Rev Genet. 21:721–736. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Copley KE and Shorter J: Repetitive elements in aging and neurodegeneration. Trends Genet. 39:381–400. 2023. View Article : Google Scholar : PubMed/NCBI

18 

Gazquez-Gutierrez A, Witteveldt J, Heras SR and Macias S: Sensing of transposable elements by the antiviral innate immune system. RNA. 27:735–752. 2021. View Article : Google Scholar : PubMed/NCBI

19 

Evans TA and Erwin JA: Retroelement-derived RNA and its role in the brain. Semin Cell Dev Biol. 114:68–80. 2021. View Article : Google Scholar

20 

Miller KN, Victorelli SG, Salmonowicz H, Dasgupta N, Liu T, Passos JF and Adams PD: Cytoplasmic DNA: Sources, sensing, and role in aging and disease. Cell. 184:5506–5526. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Cui Z and Zhao X, Amevor FK, Du X, Wang Y, Li D, Shu G, Tian Y and Zhao X: Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism. Front Immunol. 13:9433212022. View Article : Google Scholar : PubMed/NCBI

22 

Peng D, Chen L, Sun Y, Sun L, Yin Q, Deng S, Niu L, Lou F, Wang Z, Xu Z, et al: Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling. Biomed Pharmacother. 125:1099842020. View Article : Google Scholar : PubMed/NCBI

23 

Nieto M, Konigsberg M and Silva-Palacios A: Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease. Biogerontology. 25:71–82. 2024. View Article : Google Scholar

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

25 

Lee SS, Vũ TT, Weiss AS and Yeo GC: Stress-induced senescence in mesenchymal stem cells: Triggers, hallmarks, and current rejuvenation approaches. Eur J Cell Biol. 102:1513312023. View Article : Google Scholar : PubMed/NCBI

26 

Ritschka B, Storer M, Mas A, Heinzmann F, Ortells MC, Morton JP, Sansom OJ, Zender L and Keyes WM: The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes Dev. 31:172–183. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Korotkov A, Seluanov A and Gorbunova V: Sirtuin 6: Linking longevity with genome and epigenome stability. Trends Cell Biol. 31:994–1006. 2021. View Article : Google Scholar : PubMed/NCBI

28 

Feng JX and Riddle NC: Epigenetics and genome stability. Mamm Genome. 31:181–195. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Padeken J, Methot SP and Gasser SM: Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance. Nat Rev Mol Cell Biol. 23:623–640. 2022. View Article : Google Scholar : PubMed/NCBI

30 

Shevelyov YY and Ulianov SV: The nuclear lamina as an organizer of chromosome architecture. Cells. 8:1362019. View Article : Google Scholar : PubMed/NCBI

31 

Cosby RL, Chang NC and Feschotte C: Host-transposon interactions: Conflict, cooperation, and cooption. Genes Dev. 33:1098–1116. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Chuong EB, Elde NC and Feschotte C: Regulatory evolution of innate immunity through co-option of endogenous retroviruses. Science. 351:1083–1087. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Li W, Prazak L, Chatterjee N, Grüninger S, Krug L, Theodorou D and Dubnau J: Activation of transposable elements during aging and neuronal decline in Drosophila. Nat Neurosci. 16:529–531. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Wood JG, Jones BC, Jiang N, Chang C, Hosier S, Wickremesinghe P, Garcia M, Hartnett DA, Burhenn L, Neretti N and Helfand SL: Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila. Proc Natl Acad Sci USA. 113:11277–11282. 2016. View Article : Google Scholar : PubMed/NCBI

35 

De Cecco M, Criscione SW, Peterson AL, Neretti N, Sedivy JM and Kreiling JA: Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. Aging (Albany NY). 5:867–883. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, et al: Resurrection of endogenous retroviruses during aging reinforces senescence. Cell. 186:287–304.e26. 2023. View Article : Google Scholar : PubMed/NCBI

37 

Colombo AR, Elias HK and Ramsingh G: Senescence induction universally activates transposable element expression. Cell Cycle. 17:1846–1857. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Di Giorgio E, Ranzino L, Tolotto V, Dalla E, Burelli M, Gualandi N and Brancolini C: Transcription of endogenous retroviruses in senescent cells contributes to the accumulation of double-stranded RNAs that trigger an anti-viral response that reinforces senescence. Cell Death Dis. 15:1572024. View Article : Google Scholar : PubMed/NCBI

39 

Touma F, Lambert M, Martinez Villarreal A, Gantchev J, Ramchatesingh B and Litvinov IV: The ultraviolet irradiation of keratinocytes induces ectopic expression of LINE-1 retrotransposon machinery and leads to cellular senescence. Biomedicines. 11:30172023. View Article : Google Scholar : PubMed/NCBI

40 

De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, et al: L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature. 566:73–78. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Wood JG, Hillenmeyer S, Lawrence C, Chang C, Hosier S, Lightfoot W, Mukherjee E, Jiang N, Schorl C, Brodsky AS, et al: Chromatin remodeling in the aging genome of Drosophila. Aging Cell. 9:971–978. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Pérez-Mancera PA, Young ARJ and Narita M: Inside and out: The activities of senescence in cancer. Nat Rev Cancer. 14:547–558. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Hu M, Xing L, Zhang L, Liu F, Wang S, Xie Y, Wang J, Jiang H, Guo J, Li X, et al: NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation. Aging Cell. 21:e135512022. View Article : Google Scholar : PubMed/NCBI

44 

Xie Y, Han N, Li F, Wang L, Liu G, Hu M, Wang S, Wei X, Guo J, Jiang H, et al: Melatonin enhances osteoblastogenesis of senescent bone marrow stromal cells through NSD2-mediated chromatin remodelling. Clin Transl Med. 12:e7462022. View Article : Google Scholar : PubMed/NCBI

45 

Niepmann ST, Willemsen N, Boucher AS, Stei M, Goody P, Zietzer A, Bulic M, Billig H, Odainic A, Weisheit CK, et al: Toll-like receptor-3 contributes to the development of aortic valve stenosis. Basic Res Cardiol. 118:62023. View Article : Google Scholar : PubMed/NCBI

46 

Khokhani P, Rahmani NR, Kok A, Öner FC, Alblas J, Weinans H, Kruyt MC and Croes M: Use of therapeutic pathogen recognition receptor ligands for osteo-immunomodulation. Materials (Basel). 14:11192021. View Article : Google Scholar : PubMed/NCBI

47 

Lou Q, Jiang K, Xu Q, Yuan L, Xie S, Pan Y, Chen J, Wu J, Zhu J, Jiang L and Zhao M: The RIG-I-NRF2 axis regulates the mesenchymal stromal niche for bone marrow transplantation. Blood. 139:3204–3221. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Wang C, Wen L, Ling Z, Xia J, Cheng B and Peng J: Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway. Int J Mol Med 55: 4, 2025.
APA
Sun, Y., Wang, C., Wen, L., Ling, Z., Xia, J., Cheng, B., & Peng, J. (2025). Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway. International Journal of Molecular Medicine, 55, 4. https://doi.org/10.3892/ijmm.2024.5445
MLA
Sun, Y., Wang, C., Wen, L., Ling, Z., Xia, J., Cheng, B., Peng, J."Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway". International Journal of Molecular Medicine 55.1 (2025): 4.
Chicago
Sun, Y., Wang, C., Wen, L., Ling, Z., Xia, J., Cheng, B., Peng, J."Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway". International Journal of Molecular Medicine 55, no. 1 (2025): 4. https://doi.org/10.3892/ijmm.2024.5445
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Wang C, Wen L, Ling Z, Xia J, Cheng B and Peng J: Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway. Int J Mol Med 55: 4, 2025.
APA
Sun, Y., Wang, C., Wen, L., Ling, Z., Xia, J., Cheng, B., & Peng, J. (2025). Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway. International Journal of Molecular Medicine, 55, 4. https://doi.org/10.3892/ijmm.2024.5445
MLA
Sun, Y., Wang, C., Wen, L., Ling, Z., Xia, J., Cheng, B., Peng, J."Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway". International Journal of Molecular Medicine 55.1 (2025): 4.
Chicago
Sun, Y., Wang, C., Wen, L., Ling, Z., Xia, J., Cheng, B., Peng, J."Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway". International Journal of Molecular Medicine 55, no. 1 (2025): 4. https://doi.org/10.3892/ijmm.2024.5445
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team