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Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review)

  • Authors:
    • Xiaoyu Zhang
    • Lei Shi
    • Mengzhen Xing
    • Chunjing Li
    • Fengjun Ma
    • Yuning Ma
    • Yuxia Ma
  • View Affiliations / Copyright

    Affiliations: Department of Acupuncture and Massage College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250000, P.R. China, Key Laboratory of New Material Research Institute, Institute of Pharmaceutical Research, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 15
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    Published online on: November 7, 2024
       https://doi.org/10.3892/ijmm.2024.5456
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Abstract

Long non‑coding RNA (lncRNA) is a class of non‑coding RNA molecules located in the cytoplasm or nucleus, which can regulate chromosome structure and function by interacting with DNA, RNA, proteins and other molecules; binding to mRNA bases in a complementary manner, affecting the splicing, stabilization, translation and degradation of mRNA; acting as competing endogenous RNA competitively binds to microRNAs to regulate gene expression and participate in the regulation of various vital activities of the body. The PI3K/AKT signalling pathway plays a key role in numerous biological and cellular processes, such as cell proliferation, invasion, migration and angiogenesis. It has been found that the lncRNA/PI3K/AKT axis regulates the expression of cancer‑related genes and thus tumour progression. The abnormal regulation of lncRNA expression in the lncRNA/PI3K/AKT axis is clearly associated with clinicopathological features and plays an important role in regulating biological functions. In the present review, the expression and biological functions of PI3K/AKT‑related lncRNAs both in vitro and in vivo over recent years, were comprehensively summarized and analyzed. Their correlation with clinicopathological features was also evaluated, with the objective of furnishing a solid theoretical foundation for clinical diagnosis and the monitoring of efficacy in digestive system neoplasms. The present review aimed to provide a comprehensive overview of the expression and biological functions of PI3K/AKT‑related lncRNAs in digestive system neoplasms and to assess their correlation with clinicopathological features. This endeavor seeks to establish a solid theoretical foundation for the clinical diagnosis and efficacy monitoring of digestive system tumors.
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Zhang X, Shi L, Xing M, Li C, Ma F, Ma Y and Ma Y: Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review). Int J Mol Med 55: 15, 2025.
APA
Zhang, X., Shi, L., Xing, M., Li, C., Ma, F., Ma, Y., & Ma, Y. (2025). Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review). International Journal of Molecular Medicine, 55, 15. https://doi.org/10.3892/ijmm.2024.5456
MLA
Zhang, X., Shi, L., Xing, M., Li, C., Ma, F., Ma, Y., Ma, Y."Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review)". International Journal of Molecular Medicine 55.1 (2025): 15.
Chicago
Zhang, X., Shi, L., Xing, M., Li, C., Ma, F., Ma, Y., Ma, Y."Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review)". International Journal of Molecular Medicine 55, no. 1 (2025): 15. https://doi.org/10.3892/ijmm.2024.5456
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Spandidos Publications style
Zhang X, Shi L, Xing M, Li C, Ma F, Ma Y and Ma Y: Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review). Int J Mol Med 55: 15, 2025.
APA
Zhang, X., Shi, L., Xing, M., Li, C., Ma, F., Ma, Y., & Ma, Y. (2025). Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review). International Journal of Molecular Medicine, 55, 15. https://doi.org/10.3892/ijmm.2024.5456
MLA
Zhang, X., Shi, L., Xing, M., Li, C., Ma, F., Ma, Y., Ma, Y."Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review)". International Journal of Molecular Medicine 55.1 (2025): 15.
Chicago
Zhang, X., Shi, L., Xing, M., Li, C., Ma, F., Ma, Y., Ma, Y."Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review)". International Journal of Molecular Medicine 55, no. 1 (2025): 15. https://doi.org/10.3892/ijmm.2024.5456
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