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Review Open Access

Role of solute carrier transporters in ovarian cancer (Review)

  • Authors:
    • Barbara Quaresima
    • Stefania Scicchitano
    • Maria Concetta Faniello
    • Maria Mesuraca
  • View Affiliations / Copyright

    Affiliations: Department of Experimental and Clinical Medicine, ‘Magna Graecia’ University of Catanzaro, I-88100 Catanzaro, Italy
    Copyright: © Quaresima et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 24
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    Published online on: November 27, 2024
       https://doi.org/10.3892/ijmm.2024.5465
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Abstract

Solute carrier (SLC) transporters are involved in various biological processes associated with metabolic reprogramming and cancer, supporting the increased requirement of nutrients and energy. Over the past decade, there have been significant advancements in understanding the expression and function of SLCs in ovarian cancer (OC). This gynecological condition has a high mortality rate and limited treatment options; thus, early diagnosis remains a target clinically. OC exhibits complexity and heterogeneity, resulting in different clinical characteristics, resistance to chemotherapy drugs and poor prognosis. Additionally, SLCs have a different expression pattern between healthy and tumor tissue, and consequently, their inhibition or activation could modify signaling pathways involved in the tumor growth process, such as cell proliferation, apoptosis and drug accumulation. The present review aims to consolidate current data to provide a comprehensive understanding of the potential importance of SLCs in OC. Additionally, it seeks to offer guidance for further research on utilizing SLCs as prognostic biomarkers and therapeutic targets.
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Copy and paste a formatted citation
Spandidos Publications style
Quaresima B, Scicchitano S, Faniello MC and Mesuraca M: Role of solute carrier transporters in ovarian cancer (Review). Int J Mol Med 55: 24, 2025.
APA
Quaresima, B., Scicchitano, S., Faniello, M.C., & Mesuraca, M. (2025). Role of solute carrier transporters in ovarian cancer (Review). International Journal of Molecular Medicine, 55, 24. https://doi.org/10.3892/ijmm.2024.5465
MLA
Quaresima, B., Scicchitano, S., Faniello, M. C., Mesuraca, M."Role of solute carrier transporters in ovarian cancer (Review)". International Journal of Molecular Medicine 55.2 (2025): 24.
Chicago
Quaresima, B., Scicchitano, S., Faniello, M. C., Mesuraca, M."Role of solute carrier transporters in ovarian cancer (Review)". International Journal of Molecular Medicine 55, no. 2 (2025): 24. https://doi.org/10.3892/ijmm.2024.5465
Copy and paste a formatted citation
x
Spandidos Publications style
Quaresima B, Scicchitano S, Faniello MC and Mesuraca M: Role of solute carrier transporters in ovarian cancer (Review). Int J Mol Med 55: 24, 2025.
APA
Quaresima, B., Scicchitano, S., Faniello, M.C., & Mesuraca, M. (2025). Role of solute carrier transporters in ovarian cancer (Review). International Journal of Molecular Medicine, 55, 24. https://doi.org/10.3892/ijmm.2024.5465
MLA
Quaresima, B., Scicchitano, S., Faniello, M. C., Mesuraca, M."Role of solute carrier transporters in ovarian cancer (Review)". International Journal of Molecular Medicine 55.2 (2025): 24.
Chicago
Quaresima, B., Scicchitano, S., Faniello, M. C., Mesuraca, M."Role of solute carrier transporters in ovarian cancer (Review)". International Journal of Molecular Medicine 55, no. 2 (2025): 24. https://doi.org/10.3892/ijmm.2024.5465
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