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Clinical updates of B‑cell maturation antigen‑targeted therapy in multiple myeloma (MM) and relapsed/refractory MM (Review)

  • Authors:
    • Rui Xing
    • Meidan Wang
    • Liqun Wang
    • Mingyue Pan
    • Yixi Wang
    • Hongwei Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Dongyang Hospital Affiliated to Wenzhou Medical University, Dongyang People's Hospital, Dongyang, Zhejiang 322100, P.R. China, Faculty of Biology, University of Freiburg, D‑79104 Freiburg, Germany, Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150040, P.R. China, Faculty of Law, University of Freiburg, D‑79098 Freiburg, Germany, Department of Rehabilitation Medicine, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing 402260, P.R. China, Department of Gastrointestinal Surgery, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421002, P.R. China
    Copyright: © Xing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 27
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    Published online on: December 6, 2024
       https://doi.org/10.3892/ijmm.2024.5468
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Abstract

Despite significant progress in managing multiple myeloma (MM) in recent years, certain patients still have a short duration of therapeutic response, often relapsing within 18 months. These patients typically have high‑risk genetic mutations and may show little to no response to current treatments, highlighting the need for further exploration of optimal therapeutic targets for MM. B‑cell maturation antigen (BCMA), highly expressed in mature B lymphocytes and plasma cells and upregulated in MM, is a promising therapeutic target. Various BCMA‑targeted strategies, including antibody‑drug conjugates, bispecific T‑cell engagers and chimeric antigen receptor T‑cell therapy, are under clinical evaluation to optimize efficacy and safety. This review summarizes the latest clinical updates on these strategies, highlights their effectiveness in MM and relapsed/refractory MM and provides future perspectives and recommendations for overcoming current challenges.
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Copy and paste a formatted citation
Spandidos Publications style
Xing R, Wang M, Wang L, Pan M, Wang Y and Zhou H: Clinical updates of B‑cell maturation antigen‑targeted therapy in multiple myeloma (MM) and relapsed/refractory MM (Review). Int J Mol Med 55: 27, 2025.
APA
Xing, R., Wang, M., Wang, L., Pan, M., Wang, Y., & Zhou, H. (2025). Clinical updates of B‑cell maturation antigen‑targeted therapy in multiple myeloma (MM) and relapsed/refractory MM (Review). International Journal of Molecular Medicine, 55, 27. https://doi.org/10.3892/ijmm.2024.5468
MLA
Xing, R., Wang, M., Wang, L., Pan, M., Wang, Y., Zhou, H."Clinical updates of B‑cell maturation antigen‑targeted therapy in multiple myeloma (MM) and relapsed/refractory MM (Review)". International Journal of Molecular Medicine 55.2 (2025): 27.
Chicago
Xing, R., Wang, M., Wang, L., Pan, M., Wang, Y., Zhou, H."Clinical updates of B‑cell maturation antigen‑targeted therapy in multiple myeloma (MM) and relapsed/refractory MM (Review)". International Journal of Molecular Medicine 55, no. 2 (2025): 27. https://doi.org/10.3892/ijmm.2024.5468
Copy and paste a formatted citation
x
Spandidos Publications style
Xing R, Wang M, Wang L, Pan M, Wang Y and Zhou H: Clinical updates of B‑cell maturation antigen‑targeted therapy in multiple myeloma (MM) and relapsed/refractory MM (Review). Int J Mol Med 55: 27, 2025.
APA
Xing, R., Wang, M., Wang, L., Pan, M., Wang, Y., & Zhou, H. (2025). Clinical updates of B‑cell maturation antigen‑targeted therapy in multiple myeloma (MM) and relapsed/refractory MM (Review). International Journal of Molecular Medicine, 55, 27. https://doi.org/10.3892/ijmm.2024.5468
MLA
Xing, R., Wang, M., Wang, L., Pan, M., Wang, Y., Zhou, H."Clinical updates of B‑cell maturation antigen‑targeted therapy in multiple myeloma (MM) and relapsed/refractory MM (Review)". International Journal of Molecular Medicine 55.2 (2025): 27.
Chicago
Xing, R., Wang, M., Wang, L., Pan, M., Wang, Y., Zhou, H."Clinical updates of B‑cell maturation antigen‑targeted therapy in multiple myeloma (MM) and relapsed/refractory MM (Review)". International Journal of Molecular Medicine 55, no. 2 (2025): 27. https://doi.org/10.3892/ijmm.2024.5468
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