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Vitamin D affects antiphospholipid syndrome by regulating T cells (Review)

  • Authors:
    • Rongxiu Huo
    • Yanting Yang
    • Chengcheng Wei
    • Xiaocong Huo
    • Danli Meng
    • Yang Yang
    • Yijia Huang
    • Rongjun Huang
    • Jinying Lin
    • Xinxiang Huang
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology and Immunology, Guangxi Academy of Medical Sciences, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region 530016, P.R. China
    Copyright: © Huo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 30
    |
    Published online on: December 12, 2024
       https://doi.org/10.3892/ijmm.2024.5471
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Abstract

Antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial and/or venous thrombosis, pathological pregnancies and persistent antiphospholipid antibodies. The occurrence and development of APS are complex and associated with immune disorders, with its prognosis remaining uncertain. Owing to its pathogenesis, anticoagulation therapy is the primary treatment for patients with APS. In recent years, with increased attention on APS, research on its treatment strategies has flourished, and preclinical and clinical relevance studies are being conducted to re‑evaluate the mechanism of action of existing drugs and to develop new drugs. Recent evidence suggests that vitamin D (VD) may help improve immune disorders in patients with APS by regulating the balance between immune cells. In this review, the potential mechanistic role of VD in APS protection was discussed, highlighting the potential effects of VD as a promising adjuvant treatment option for APS.
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Copy and paste a formatted citation
Spandidos Publications style
Huo R, Yang Y, Wei C, Huo X, Meng D, Yang Y, Huang Y, Huang R, Lin J, Huang X, Huang X, et al: Vitamin D affects antiphospholipid syndrome by regulating T cells (Review). Int J Mol Med 55: 30, 2025.
APA
Huo, R., Yang, Y., Wei, C., Huo, X., Meng, D., Yang, Y. ... Huang, X. (2025). Vitamin D affects antiphospholipid syndrome by regulating T cells (Review). International Journal of Molecular Medicine, 55, 30. https://doi.org/10.3892/ijmm.2024.5471
MLA
Huo, R., Yang, Y., Wei, C., Huo, X., Meng, D., Yang, Y., Huang, Y., Huang, R., Lin, J., Huang, X."Vitamin D affects antiphospholipid syndrome by regulating T cells (Review)". International Journal of Molecular Medicine 55.2 (2025): 30.
Chicago
Huo, R., Yang, Y., Wei, C., Huo, X., Meng, D., Yang, Y., Huang, Y., Huang, R., Lin, J., Huang, X."Vitamin D affects antiphospholipid syndrome by regulating T cells (Review)". International Journal of Molecular Medicine 55, no. 2 (2025): 30. https://doi.org/10.3892/ijmm.2024.5471
Copy and paste a formatted citation
x
Spandidos Publications style
Huo R, Yang Y, Wei C, Huo X, Meng D, Yang Y, Huang Y, Huang R, Lin J, Huang X, Huang X, et al: Vitamin D affects antiphospholipid syndrome by regulating T cells (Review). Int J Mol Med 55: 30, 2025.
APA
Huo, R., Yang, Y., Wei, C., Huo, X., Meng, D., Yang, Y. ... Huang, X. (2025). Vitamin D affects antiphospholipid syndrome by regulating T cells (Review). International Journal of Molecular Medicine, 55, 30. https://doi.org/10.3892/ijmm.2024.5471
MLA
Huo, R., Yang, Y., Wei, C., Huo, X., Meng, D., Yang, Y., Huang, Y., Huang, R., Lin, J., Huang, X."Vitamin D affects antiphospholipid syndrome by regulating T cells (Review)". International Journal of Molecular Medicine 55.2 (2025): 30.
Chicago
Huo, R., Yang, Y., Wei, C., Huo, X., Meng, D., Yang, Y., Huang, Y., Huang, R., Lin, J., Huang, X."Vitamin D affects antiphospholipid syndrome by regulating T cells (Review)". International Journal of Molecular Medicine 55, no. 2 (2025): 30. https://doi.org/10.3892/ijmm.2024.5471
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