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Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review)

  • Authors:
    • Simin Gu
    • Yiyuan Zheng
    • Chong Chen
    • Jing Liu
    • Yanping Wang
    • Junmin Wang
    • Yong Li
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China
    Copyright: © Gu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 37
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    Published online on: December 24, 2024
       https://doi.org/10.3892/ijmm.2024.5478
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Abstract

Bupleurum, a Traditional Chinese Medicine (TCM) herb, is widely used in China and other Asian countries to manage chronic liver inflammation and viral hepatitis. Saikosaponin D (SSD), a triterpenoid saponin extracted from Bupleurum, exhibits extensive pharmacological properties, including anti‑inflammatory, antioxidant, anti‑apoptotic, anti‑fibrotic and anti‑cancer effects, making it a therapeutic candidate for numerous diseases. Clarifying the targets and molecular mechanisms underlying TCM compounds is essential for scientifically validating TCM's therapeutic roles in disease prevention and treatment, as well as for identifying novel therapeutic targets and lead compounds. This analysis comprehensively examines SSD's mechanisms across various conditions, such as myocardial injury, pulmonary diseases, hepatic disorders, renal pathologies, neurological disorders, diabetes and cancer. In addition, challenges and potential solutions encountered in SSD research are addressed. SSD is posited as a promising monomer for multifaceted therapeutic applications and this article aims to enhance researchers' understanding of the current landscape of SSD studies, offering strategic insights to guide future investigations. 
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Spandidos Publications style
Gu S, Zheng Y, Chen C, Liu J, Wang Y, Wang J and Li Y: Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review). Int J Mol Med 55: 37, 2025.
APA
Gu, S., Zheng, Y., Chen, C., Liu, J., Wang, Y., Wang, J., & Li, Y. (2025). Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review). International Journal of Molecular Medicine, 55, 37. https://doi.org/10.3892/ijmm.2024.5478
MLA
Gu, S., Zheng, Y., Chen, C., Liu, J., Wang, Y., Wang, J., Li, Y."Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review)". International Journal of Molecular Medicine 55.3 (2025): 37.
Chicago
Gu, S., Zheng, Y., Chen, C., Liu, J., Wang, Y., Wang, J., Li, Y."Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review)". International Journal of Molecular Medicine 55, no. 3 (2025): 37. https://doi.org/10.3892/ijmm.2024.5478
Copy and paste a formatted citation
x
Spandidos Publications style
Gu S, Zheng Y, Chen C, Liu J, Wang Y, Wang J and Li Y: Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review). Int J Mol Med 55: 37, 2025.
APA
Gu, S., Zheng, Y., Chen, C., Liu, J., Wang, Y., Wang, J., & Li, Y. (2025). Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review). International Journal of Molecular Medicine, 55, 37. https://doi.org/10.3892/ijmm.2024.5478
MLA
Gu, S., Zheng, Y., Chen, C., Liu, J., Wang, Y., Wang, J., Li, Y."Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review)". International Journal of Molecular Medicine 55.3 (2025): 37.
Chicago
Gu, S., Zheng, Y., Chen, C., Liu, J., Wang, Y., Wang, J., Li, Y."Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review)". International Journal of Molecular Medicine 55, no. 3 (2025): 37. https://doi.org/10.3892/ijmm.2024.5478
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