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Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review)

  • Authors:
    • Wan Muhammad Farhan Syafiq Bin Wan Mohd Nor
    • Soke Chee Kwong
    • Afiqah Alyaa Md Fuzi
    • Nur Akmarina Binti Mohd Said
    • Amira Hajirah Abd Jamil
    • Yeong Yeh Lee
    • Soo Ching Lee
    • Yvonne Ai-Lian Lim
    • Ivy Chung
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia, Centre for Population Health (CePH), Department of Social and Preventive Medicine, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia, Office of Deputy Vice Chancellor (Research and Innovation), Universiti Malaya, 50603 Kuala Lumpur, Malaysia, Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, 50603 Kuala Lumpur, Malaysia, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kota Bharu, Malaysia, Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia
    Copyright: © Bin Wan Mohd Nor et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 46
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    Published online on: January 14, 2025
       https://doi.org/10.3892/ijmm.2025.5487
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Abstract

Colorectal cancer (CRC), an emerging public health concern, is one of the leading causes of cancer morbidity and mortality worldwide. An increasing body of evidence shows that dysfunction in metabolic reprogramming is a crucial characteristic of CRC progression. Specifically, metabolic reprogramming abnormalities in glucose, glutamine and lipid metabolism provide the tumour with energy and nutrients to support its rapid cell proliferation and survival. More recently, microRNAs (miRNAs) appear to be involved in the pathogenesis of CRC, including regulatory roles in energy metabolism. In addition, it has been revealed that dysbiosis in CRC might play a key role in impairing the host metabolic reprogramming processes, and while the exact interactions remain unclear, the link may lie with miRNAs. Hence, the aims of the current review include first, to delineate the metabolic reprogramming abnormalities in CRC; second, to explain how miRNAs mediate the aberrant regulations of CRC metabolic pathways; third, linking miRNAs with metabolic abnormalities and dysbiosis in CRC and finally, to discuss the roles of miRNAs as potential biomarkers.
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Copy and paste a formatted citation
Spandidos Publications style
Bin Wan Mohd Nor W, Kwong S, Fuzi A, Said N, Jamil A, Lee Y, Lee S, Lim Y and Chung I: Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review). Int J Mol Med 55: 46, 2025.
APA
Bin Wan Mohd Nor, W., Kwong, S., Fuzi, A., Said, N., Jamil, A., Lee, Y. ... Chung, I. (2025). Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review). International Journal of Molecular Medicine, 55, 46. https://doi.org/10.3892/ijmm.2025.5487
MLA
Bin Wan Mohd Nor, W., Kwong, S., Fuzi, A., Said, N., Jamil, A., Lee, Y., Lee, S., Lim, Y., Chung, I."Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review)". International Journal of Molecular Medicine 55.3 (2025): 46.
Chicago
Bin Wan Mohd Nor, W., Kwong, S., Fuzi, A., Said, N., Jamil, A., Lee, Y., Lee, S., Lim, Y., Chung, I."Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review)". International Journal of Molecular Medicine 55, no. 3 (2025): 46. https://doi.org/10.3892/ijmm.2025.5487
Copy and paste a formatted citation
x
Spandidos Publications style
Bin Wan Mohd Nor W, Kwong S, Fuzi A, Said N, Jamil A, Lee Y, Lee S, Lim Y and Chung I: Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review). Int J Mol Med 55: 46, 2025.
APA
Bin Wan Mohd Nor, W., Kwong, S., Fuzi, A., Said, N., Jamil, A., Lee, Y. ... Chung, I. (2025). Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review). International Journal of Molecular Medicine, 55, 46. https://doi.org/10.3892/ijmm.2025.5487
MLA
Bin Wan Mohd Nor, W., Kwong, S., Fuzi, A., Said, N., Jamil, A., Lee, Y., Lee, S., Lim, Y., Chung, I."Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review)". International Journal of Molecular Medicine 55.3 (2025): 46.
Chicago
Bin Wan Mohd Nor, W., Kwong, S., Fuzi, A., Said, N., Jamil, A., Lee, Y., Lee, S., Lim, Y., Chung, I."Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review)". International Journal of Molecular Medicine 55, no. 3 (2025): 46. https://doi.org/10.3892/ijmm.2025.5487
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