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Importance of STAT3 signaling in preeclampsia (Review)

  • Authors:
    • Daniela Marzioni
    • Federica Piani
    • Nicoletta Di Simone
    • Stefano Raffaele Giannubilo
    • Andrea Ciavattini
    • Giovanni Tossetta
  • View Affiliations / Copyright

    Affiliations: Department of Experimental and Clinical Medicine, Polytechnic University of Marche, I‑60126 Ancona, Italy, Hypertension and Cardiovascular Risk Research Center, Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, I‑40126 Bologna, Italy, Department of Biomedical Sciences, Humanitas University, I‑20072 Milan, Italy, Department of Clinical Sciences, Polytechnic University of Marche, I‑60123 Ancona, Italy
    Copyright: © Marzioni et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 58
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    Published online on: February 6, 2025
       https://doi.org/10.3892/ijmm.2025.5499
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Abstract

Placentation is a key process that is tightly regulated that ensures the normal placenta and fetal development. Preeclampsia (PE) is a hypertensive pregnancy‑associated disorder characterized by increased oxidative stress and inflammation. STAT3 signaling plays a key role in modulating important processes such as cell proliferation, differentiation, invasion and apoptosis. The present review aimed to analyse the role of STAT3 signaling in PE pregnancies, discuss the main natural and synthetic compounds involved in modulation of this signaling both in vivo and in vitro and summarize the main cellular modulators of this signaling to identify possible therapeutic targets and treatments to improve the outcome of PE pregnancies.
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Copy and paste a formatted citation
Spandidos Publications style
Marzioni D, Piani F, Di Simone N, Giannubilo SR, Ciavattini A and Tossetta G: Importance of STAT3 signaling in preeclampsia (Review). Int J Mol Med 55: 58, 2025.
APA
Marzioni, D., Piani, F., Di Simone, N., Giannubilo, S.R., Ciavattini, A., & Tossetta, G. (2025). Importance of STAT3 signaling in preeclampsia (Review). International Journal of Molecular Medicine, 55, 58. https://doi.org/10.3892/ijmm.2025.5499
MLA
Marzioni, D., Piani, F., Di Simone, N., Giannubilo, S. R., Ciavattini, A., Tossetta, G."Importance of STAT3 signaling in preeclampsia (Review)". International Journal of Molecular Medicine 55.4 (2025): 58.
Chicago
Marzioni, D., Piani, F., Di Simone, N., Giannubilo, S. R., Ciavattini, A., Tossetta, G."Importance of STAT3 signaling in preeclampsia (Review)". International Journal of Molecular Medicine 55, no. 4 (2025): 58. https://doi.org/10.3892/ijmm.2025.5499
Copy and paste a formatted citation
x
Spandidos Publications style
Marzioni D, Piani F, Di Simone N, Giannubilo SR, Ciavattini A and Tossetta G: Importance of STAT3 signaling in preeclampsia (Review). Int J Mol Med 55: 58, 2025.
APA
Marzioni, D., Piani, F., Di Simone, N., Giannubilo, S.R., Ciavattini, A., & Tossetta, G. (2025). Importance of STAT3 signaling in preeclampsia (Review). International Journal of Molecular Medicine, 55, 58. https://doi.org/10.3892/ijmm.2025.5499
MLA
Marzioni, D., Piani, F., Di Simone, N., Giannubilo, S. R., Ciavattini, A., Tossetta, G."Importance of STAT3 signaling in preeclampsia (Review)". International Journal of Molecular Medicine 55.4 (2025): 58.
Chicago
Marzioni, D., Piani, F., Di Simone, N., Giannubilo, S. R., Ciavattini, A., Tossetta, G."Importance of STAT3 signaling in preeclampsia (Review)". International Journal of Molecular Medicine 55, no. 4 (2025): 58. https://doi.org/10.3892/ijmm.2025.5499
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