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miR‑100: A key tumor suppressor regulatory factor in human malignant tumors (Review)

  • Authors:
    • Liang Zhang
    • Jiuling Zhang
    • Xue Zhang
    • Shuang Liu
    • Chunyu Qi
    • Shengyu Gao
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery I, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China, School of Basic Medical Sciences, Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 67
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    Published online on: February 25, 2025
       https://doi.org/10.3892/ijmm.2025.5508
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Abstract

MicroRNA (miRNA/miR)‑100 is a crucial tumor‑suppressive miRNA that serves a pivotal role in the initiation and progression of various malignancies. miR‑100 regulates cancer cell proliferation, migration, invasion and apoptosis by targeting oncogenes, and acts as a molecular sponge to regulate long non‑coding RNAs and circular RNAs, thereby influencing processes such as glycolysis, autophagy and resistance to chemotherapy/radiotherapy. Furthermore, miR‑100 suppresses tumor progression by modulating key signaling pathways, including the PI3K/AKT and Wnt/β‑catenin signaling pathways. miR‑100 exhibits potential for early cancer diagnosis, particularly in cancer types such as gastric and lung cancer, where it can serve as a non‑invasive biomarker for early screening. As a therapeutic target, restoring miR‑100 expression can enhance the efficacy of chemotherapy or targeted therapy, thereby improving patient prognosis. Although challenges remain in its clinical application, including delivery systems and safety concerns, ongoing research suggests that miR‑100 holds promise for personalized treatment and early diagnosis. Given that cancer remains a global health challenge, research on miR‑100 provides hope for cancer therapy, particularly in China, where the mortality rates of malignancies such as gastric, lung and liver cancer continue to rise, further emphasizing its potential for clinical translation.
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Zhang L, Zhang J, Zhang X, Liu S, Qi C and Gao S: miR‑100: A key tumor suppressor regulatory factor in human malignant tumors (Review). Int J Mol Med 55: 67, 2025.
APA
Zhang, L., Zhang, J., Zhang, X., Liu, S., Qi, C., & Gao, S. (2025). miR‑100: A key tumor suppressor regulatory factor in human malignant tumors (Review). International Journal of Molecular Medicine, 55, 67. https://doi.org/10.3892/ijmm.2025.5508
MLA
Zhang, L., Zhang, J., Zhang, X., Liu, S., Qi, C., Gao, S."miR‑100: A key tumor suppressor regulatory factor in human malignant tumors (Review)". International Journal of Molecular Medicine 55.4 (2025): 67.
Chicago
Zhang, L., Zhang, J., Zhang, X., Liu, S., Qi, C., Gao, S."miR‑100: A key tumor suppressor regulatory factor in human malignant tumors (Review)". International Journal of Molecular Medicine 55, no. 4 (2025): 67. https://doi.org/10.3892/ijmm.2025.5508
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Spandidos Publications style
Zhang L, Zhang J, Zhang X, Liu S, Qi C and Gao S: miR‑100: A key tumor suppressor regulatory factor in human malignant tumors (Review). Int J Mol Med 55: 67, 2025.
APA
Zhang, L., Zhang, J., Zhang, X., Liu, S., Qi, C., & Gao, S. (2025). miR‑100: A key tumor suppressor regulatory factor in human malignant tumors (Review). International Journal of Molecular Medicine, 55, 67. https://doi.org/10.3892/ijmm.2025.5508
MLA
Zhang, L., Zhang, J., Zhang, X., Liu, S., Qi, C., Gao, S."miR‑100: A key tumor suppressor regulatory factor in human malignant tumors (Review)". International Journal of Molecular Medicine 55.4 (2025): 67.
Chicago
Zhang, L., Zhang, J., Zhang, X., Liu, S., Qi, C., Gao, S."miR‑100: A key tumor suppressor regulatory factor in human malignant tumors (Review)". International Journal of Molecular Medicine 55, no. 4 (2025): 67. https://doi.org/10.3892/ijmm.2025.5508
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