Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
June-2025 Volume 55 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2025 Volume 55 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Honokiol ameliorates pyroptosis in intestinal ischemia‑reperfusion injury by regulating the SIRT3‑mediated NLRP3 inflammasome

  • Authors:
    • Ke Wu
    • Qiuling Wang
    • Zhengyu Zhang
    • Wei Luo
    • Jing Peng
    • Xin Ma
    • Li Wang
    • Chunguang Xie
    • Wubin Guo
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Research Center of Integrative Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 96
    |
    Published online on: April 25, 2025
       https://doi.org/10.3892/ijmm.2025.5537
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Intestinal ischemia‑reperfusion (IIR) injury is caused by the restoration of blood supply after a period of ischemia. It occurs in numerous clinical pathologies, such as intestinal obstruction, incarcerated hernia and septic shock, with mortality rates of 50‑80%. Honokiol (HKL), isolated from the herb Magnolia officinalis, is a biphenolic natural product with antioxidative, antibacterial, antitumor and anti‑inflammatory properties. Additionally, HKL has protective effects in ischemia‑reperfusion injuries, but its role and specific mechanisms in IIR injury are yet to be elucidated. In the present study, the superior mesenteric artery was ligated in rats to establish an IIR model. Hematoxylin and eosin staining and ELISA revealed that HKL administration ameliorated IIR‑induced injury in rats, which was demonstrated by a reduced destruction to the intestinal mucosa, as well as a reduced serum intestinal fatty acid‑binding protein concentration and Chiu's score in 10 mg/kg HKL treated IIR‑induced rats compared with those without HKL treatment. Additionally, immunohistochemical (IHC) staining and western blotting revealed that the occludin and tight junction protein 1 protein levels were increased in the 10 mg/kg HKL treated IIR‑induced rats compared with those without HKL treatment. Furthermore, an in vitro hypoxia/reoxygenation (H/R) cell model was established using IEC‑6 cells. Cell Counting Kit‑8 and lactate dehydrogenase (LDH) assays indicated that HKL mitigated the H/R‑inhibited cell viability and decreased the LDH levels in cell supernatants. Mechanistically, immunofluorescent (IF) staining and western blotting revealed that HKL inhibited H/R‑triggered pyroptosis. Furthermore, Mito‑Tracker, mitochondrial membrane potential and MitoSOX staining as well as western blotting revealed that reducing mitochondrial reactive oxygen species (ROS) inhibited the H/R‑induced pyroptosis by mitigating mitochondrial dysfunction. In the present H/R cell model, HKL improved the mitochondrial function by increasing the expression of sirtuin 3 (SIRT3), while IF staining and western blotting indicated that silencing SIRT3 notably reduced the beneficial effect of HKL on pyroptosis. In addition, IHC staining and western blotting revealed that HKL treatment mitigated the IIR‑induced pyroptosis in rats. Therefore, HKL treatment may mitigate IIR‑induced mitochondrial dysfunction and reduce mitochondrial ROS production by increasing the expression of SIRT3 protein, potentially resulting in an inhibition of pyroptosis during IIR.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Jin B, Li G, Zhou L and Fan Z: Mechanism involved in acute liver injury induced by intestinal Ischemia-reperfusion. Front Pharmacol. 13:9246952022. View Article : Google Scholar : PubMed/NCBI

2 

Tassopoulos A, Chalkias A, Papalois A, Iacovidou N and Xanthos T: The effect of antioxidant supplementation on bacterial translocation after intestinal ischemia and reperfusion. Redox Rep. 22:1–9. 2017. View Article : Google Scholar

3 

Taylor LM Jr and Moneta GL: Intestinal ischemia. Ann Vasc Surg. 5:403–406. 1991. View Article : Google Scholar : PubMed/NCBI

4 

Slone EA and Fleming SD: Membrane lipid interactions in intestinal ischemia/reperfusion-induced Injury. Clin Immunol. 153:228–240. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Stamatakos M, Stefanaki C, Mastrokalos D, Arampatzi H, Safioleas P, Chatziconstantinou C, Xiromeritis C and Safioleas M: Mesenteric ischemia: Still a deadly puzzle for the medical community. Tohoku J Exp Med. 216:197–204. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Li G, Wang S and Fan Z: Oxidative stress in intestinal ischemia-reperfusion. Front Med (Lausanne). 8:7507312022. View Article : Google Scholar : PubMed/NCBI

7 

Zhang X, Wu J, Liu Q, Li X, Li S, Chen J, Hong Z, Wu X, Zhao Y and Ren J: mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion. Cell Death Dis. 11:10502020. View Article : Google Scholar : PubMed/NCBI

8 

Subramanian S, Geng H and Tan XD: Cell death of intestinal epithelial cells in intestinal diseases. Sheng Li Xue Bao. 72:308–324. 2020.PubMed/NCBI

9 

Li Y, Feng D, Wang Z, Zhao Y, Sun R, Tian D, Liu D, Zhang F, Ning S, Yao J and Tian X: Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion. Cell Death Differ. 26:2284–2299. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Wei Y, Yang L, Pandeya A, Cui J, Zhang Y and Li Z: Pyroptosis-induced inflammation and tissue damage. J Mol Biol. 434:1673012022. View Article : Google Scholar :

11 

Rao Z, Zhu Y, Yang P, Chen Z, Xia Y, Qiao C, Liu W, Deng H, Li J, Ning P, et al: Pyroptosis in inflammatory diseases and cancer. Theranostics. 12:4310–4329. 2022. View Article : Google Scholar : PubMed/NCBI

12 

Ji X, Tian L, Niu S, Yao S and Qu C: Trimethylamine N-oxide promotes demyelination in spontaneous hypertension rats through enhancing pyroptosis of oligodendrocytes. Front Aging Neurosci. 14:9638762022. View Article : Google Scholar : PubMed/NCBI

13 

Wang Y, Chen J, Zheng Y, Jiang J, Wang L, Wu J, Zhang C and Luo M: Glucose metabolite methylglyoxal induces vascular endothelial cell pyroptosis via NLRP3 inflammasome activation and oxidative stress in vitro and in vivo. Cell Mol Life Sci. 81:4012024. View Article : Google Scholar : PubMed/NCBI

14 

Vasudevan SO, Behl B and Rathinam VA: Pyroptosis-induced inflammation and tissue damage. Semin Immunol. 69:1017812023. View Article : Google Scholar : PubMed/NCBI

15 

Guo Q, Wu Y, Hou Y, Liu Y, Liu T, Zhang H, Fan C, Guan H, Li Y, Shan Z and Teng W: Cytokine secretion and pyroptosis of thyroid follicular cells mediated by enhanced NLRP3, NLRP1, NLRC4, and AIM2 inflammasomes are associated with autoimmune thyroiditis. Front Immunol. 9:11972018. View Article : Google Scholar : PubMed/NCBI

16 

Karki R, Sharma BR, Tuladhar S, Williams EP, Zalduondo L, Samir P, Zheng M, Sundaram B, Banoth B, Malireddi RKS, et al: Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. Cell. 184:149–168.e17. 2021. View Article : Google Scholar

17 

Li Y, Yuan Y, Huang ZX, Chen H, Lan R, Wang Z, Lai K, Chen H, Chen Z, Zou Z, et al: GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy. Cell Death Differ. 28:2333–2350. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Coll RC, Schroder K and Pelegrín P: NLRP3 and pyroptosis blockers for treating inflammatory diseases. Trends Pharmacol Sci. 43:653–668. 2022. View Article : Google Scholar : PubMed/NCBI

19 

Bai B, Yang Y, Wang Q, Li M, Tian C, Liu Y, Aung LHH, Li PF, Yu T and Chu XM: NLRP3 inflammasome in endothelial dysfunction. Cell Death Dis. 11:7762020. View Article : Google Scholar : PubMed/NCBI

20 

Huang Y, Xu W and Zhou R: NLRP3 inflammasome activation and cell death. Cell Mol Immunol. 18:2114–2127. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Zhang L, Ai C, Bai M, Niu J and Zhang Z: NLRP3 Inflammasome/Pyroptosis: A key driving force in diabetic cardiomyopathy. Int J Mol Sci. 23:106322022. View Article : Google Scholar : PubMed/NCBI

22 

Kovacs SB and Miao EA: Gasdermins: Effectors of pyroptosis. Trends Cell Biol. 27:673–684. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Jia Y, Cui R, Wang C, Feng Y, Li Z, Tong Y, Qu K, Liu C and Zhang J: Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway. Redox Biol. 32:1015342020. View Article : Google Scholar : PubMed/NCBI

24 

Li W, Yang K, Li B, Wang Y, Liu J, Chen D and Diao Y: Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis. Front Pharmacol. 13:10601042022. View Article : Google Scholar : PubMed/NCBI

25 

Chen Y, Han B, Guan X, Du G, Sheng B, Tang X, Zhang Q, Xie H, Jiang X, Tan Q, et al: Enteric fungi protect against intestinal ischemia-reperfusion injury via inhibiting the SAA1-GSDMD pathway. J Adv Res. 61:223–237. 2024. View Article : Google Scholar

26 

Hu Q, Ren J, Li G, Wu J, Wu X, Wang G, Gu G, Ren H, Hong Z and Li J: The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway. Cell Death Dis. 9:4032018. View Article : Google Scholar : PubMed/NCBI

27 

Liao S, Luo J, Kadier T, Ding K, Chen R and Meng Q: Mitochondrial DNA release contributes to intestinal ischemia/reperfusion injury. Front Pharmacol. 13:8549942022. View Article : Google Scholar : PubMed/NCBI

28 

Zhang Y, Lv Y, Zhang Q, Wang X, Han Q, Liang Y, He S, Yuan Q, Zheng J, Xu C, et al: ALDH2 attenuates myocardial pyroptosis through breaking down Mitochondrion-NLRP3 inflammasome pathway in septic shock. Front Pharmacol. 14:11258662023. View Article : Google Scholar : PubMed/NCBI

29 

Cheon SY, Kim MY, Kim J, Kim EJ, Kam EH, Cho I, Koo BN and Kim SY: Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy. Biomed J. 46:1005932023. View Article : Google Scholar : PubMed/NCBI

30 

Li Z, Wang B, Tian L, Zheng B, Zhao X and Liu R: Methane-rich saline suppresses ER-mitochondria contact and activation of the NLRP3 inflammasome by regulating the PERK signaling pathway to ameliorate intestinal Ischemia-reperfusion injury. Inflammation. 47:376–389. 2024. View Article : Google Scholar

31 

Mao H, Zhang Y, Xiong Y, Zhu Z, Wang L and Liu X: Mitochondria-targeted antioxidant mitoquinone maintains mitochondrial homeostasis through the Sirt3-dependent pathway to mitigate oxidative damage caused by renal ischemia/reperfusion. Oxid Med Cell Longev. 2022:22135032022. View Article : Google Scholar : PubMed/NCBI

32 

Zhang Q, Liu XM, Hu Q, Liu ZR, Liu ZY, Zhang HG, Huang YL, Chen QH, Wang WX and Zhang XK: Dexmedetomidine inhibits mitochondria damage and apoptosis of enteric glial cells in experimental intestinal ischemia/reperfusion injury via SIRT3-dependent PINK1/HDAC3/p53 pathway. J Transl Med. 19:4632021. View Article : Google Scholar : PubMed/NCBI

33 

Shen X, Shi H, Chen X, Han J, Liu H, Yang J, Shi Y and Ma J: Esculetin alleviates inflammation, oxidative stress and apoptosis in intestinal ischemia/reperfusion injury via targeting SIRT3/AMPK/mTOR signaling and regulating autophagy. J Inflamm Res. 16:3655–3667. 2023. View Article : Google Scholar : PubMed/NCBI

34 

Wang Z, Sun R, Wang G, Chen Z, Li Y, Zhao Y, Liu D, Zhao H, Zhang F, Yao J, et al: SIRT3-mediated deacetylation of PRDX3 alleviates mitochondrial oxidative damage and apoptosis induced by intestinal ischemia/reperfusion injury. Redox Biol. 28:1013432020. View Article : Google Scholar

35 

Chen HH, Chang PC, Chen C and Chan MH: Protective and therapeutic activity of honokiol in reversing motor deficits and neuronal degeneration in the mouse model of Parkinson's disease. Pharmacol Rep. 70:668–676. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Huang K, Chen Y, Zhang R, Wu Y, Ma Y, Fang X and Shen S: Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo. Cell Death Dis. 9:1572018. View Article : Google Scholar : PubMed/NCBI

37 

Zhou Y, Tang J, Lan J, Zhang Y, Wang H, Chen Q, Kang Y, Sun Y, Feng X, Wu L, et al: Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis. Acta Pharm Sin B. 13:577–597. 2023. View Article : Google Scholar : PubMed/NCBI

38 

Pillai VB, Samant S, Sundaresan NR, Raghuraman H, Kim G, Bonner MY, Arbiser JL, Walker DI, Jones DP, Gius D and Gupta MP: Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. Nat Commun. 6:66562015. View Article : Google Scholar : PubMed/NCBI

39 

Zhang Y, Wen P, Luo J, Ding H, Cao H, He W, Zen K, Zhou Y, Yang J and Jiang L: Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis. Cell Death Dis. 12:8472021. View Article : Google Scholar : PubMed/NCBI

40 

Mao RW, He SP, Lan JG and Zhu WZ: Honokiol ameliorates cisplatin-induced acute kidney injury via inhibition of mitochondrial fission. Br J Pharmacol. 179:3886–3904. 2022. View Article : Google Scholar : PubMed/NCBI

41 

Gao Y, Chen H, Cang X, Chen H, Di Y, Qi J, Cai H, Luo K and Jin S: Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischemia-reperfusion injury via intrinsic and paracrine mechanisms in a rat model. Front Cell Dev Biol. 10:10165972022. View Article : Google Scholar : PubMed/NCBI

42 

Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, et al: Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin. 41:1208–1222. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Zhang B, Zhai M, Li B, Liu Z, Li K, Jiang L, Zhang M, Yi W, Yang J, Yi D, et al: Honokiol ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by reducing oxidative stress and apoptosis through activating the SIRT1-Nrf2 signaling pathway. Oxid Med Cell Longev. 2018:31598012018. View Article : Google Scholar : PubMed/NCBI

44 

Zheng J, Shi L, Liang F, Xu W, Li T, Gao L, Sun Z, Yu J and Zhang J: Sirt3 ameliorates oxidative stress and mitochondrial dysfunction after intracerebral hemorrhage in diabetic rats. Front Neurosci. 12:4142018. View Article : Google Scholar : PubMed/NCBI

45 

Lv L, Kong Q, Li Z and Zhang Y, Chen B, Lv L and Zhang Y: Honokiol provides cardioprotection from myocardial ischemia/reperfusion injury (MI/RI) by inhibiting mitochondrial apoptosis via the PI3K/AKT signaling pathway. Cardiovasc Ther. 2022:10016922022. View Article : Google Scholar : PubMed/NCBI

46 

Cong R, Sun L, Yang J, Cui H, Ji X, Zhu J, Gu JH and He B: Protein O-GlcNAcylation alleviates small intestinal injury induced by ischemia-reperfusion and oxygen-glucose deprivation. Biomed Pharmacother. 138:1114772021. View Article : Google Scholar : PubMed/NCBI

47 

Han X, Yao W, Liu Z, Li H, Zhang ZJ, Hei Z and Xia Z: Lipoxin A4 preconditioning attenuates intestinal ischemia reperfusion injury through keap1/Nrf2 pathway in a lipoxin A4 receptor independent manner. Oxid Med Cell Longev. 2016:93036062016. View Article : Google Scholar : PubMed/NCBI

48 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

49 

Li Y, Xu B, Xu M, Chen D, Xiong Y, Lian M, Sun Y, Tang Z, Wang L, Jiang C and Lin Y: 6-Gingerol protects intestinal barrier from ischemia/reperfusion-induced damage via inhibition of p38 MAPK to NF-κB signalling. Pharmacol Res. 119:137–148. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Liu Y, Zhou J, Luo Y, Li J, Shang L, Zhou F and Yang S: Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo. Chin Med. 16:1272021. View Article : Google Scholar : PubMed/NCBI

51 

Qiu L, Xu R, Wang S, Li S, Sheng H, Wu J and Qu Y: Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IκB/NF-κB, in atherosclerotic cell model. Exp Mol Med. 47:e1712015. View Article : Google Scholar

52 

Wang Y, Shi P, Chen Q, Huang Z, Zou D, Zhang J, Gao X and Lin Z: Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. J Mol Cell Biol. 11:1069–1082. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Zheng Z, Bian Y, Zhang Y, Ren G and Li G: Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis. Cell Cycle. 19:1089–1104. 2020. View Article : Google Scholar : PubMed/NCBI

54 

Feng WQ, Zhang YC, Xu ZQ, Yu SY, Huo JT, Tuersun A, Zheng MH, Zhao JK, Zong YP and Lu AG: IL-17A-mediated mitochondrial dysfunction induces pyroptosis in colorectal cancer cells and promotes CD8 + T-cell tumour infiltration. J Transl Med. 21:3352023. View Article : Google Scholar

55 

Zhang J, Xiang H, Liu J, Chen Y, He RR and Liu B: Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target. Theranostics. 10:8315–8342. 2020. View Article : Google Scholar : PubMed/NCBI

56 

Park EJ, Dusabimana T, Je J, Jeong K, Yun SP, Kim HJ, Kim H and Park SW: Honokiol protects the kidney from renal ischemia and reperfusion injury by upregulating the glutathione biosynthetic enzymes. Biomedicines. 8:3522020. View Article : Google Scholar : PubMed/NCBI

57 

Xu G, Dong R, Liu J, Zhao L, Zeng Y, Xiao X, An J, Huang S, Zhong Y, Guang B and Yang T: Synthesis, characterization and in vivo evaluation of honokiol bisphosphate prodrugs protects against rats' brain ischemia-reperfusion injury. Asian J Pharm Sci. 14:640–648. 2019.

58 

Zheng Y, Xu X, Chi F and Cong N: Pyroptosis: A newly discovered therapeutic target for ischemia-reperfusion injury. Biomolecules. 12:16252022. View Article : Google Scholar : PubMed/NCBI

59 

Li J, Xu P, Hong Y, Xie Y, Peng M, Sun R, Guo H, Zhang X, Zhu W, Wang J and Liu X: Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury. J Neuroinflammation. 20:1482023. View Article : Google Scholar : PubMed/NCBI

60 

Ma Q, Xu M, Jing X, Qiu J, Huang S, Yan H, Yin L, Lou J, Zhao L, Fan Y and Qiu P: Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3/IL-33/ST2 axis. Cell Death Dis. 14:1742023. View Article : Google Scholar : PubMed/NCBI

61 

Feng Y, Li M, Yangzhong X, Zhang X, Zu A, Hou Y, Li L and Sun S: Pyroptosis in inflammation-related respiratory disease. J Physiol Biochem. 78:721–737. 2022. View Article : Google Scholar : PubMed/NCBI

62 

Zheng D, Liu J, Piao H, Zhu Z, Wei R and Liu K: ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis. Front Immunol. 13:10392412022. View Article : Google Scholar : PubMed/NCBI

63 

Tuersuntuoheti M, Peng F, Li J, Zhou L, Gao H and Gong H: PLCE1 enhances mitochondrial dysfunction to promote GSDME-mediated pyroptosis in doxorubicin-induced cardiotoxicity. Biochem Pharmacol. 223:1161422024. View Article : Google Scholar : PubMed/NCBI

64 

Kerr M, Miller JJ, Thapa D, Stiewe S, Timm KN, Aparicio CNM, Scott I, Tyler DJ and Heather LC: Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol. JCI Insight. 5:e1403262020. View Article : Google Scholar : PubMed/NCBI

65 

Ji Z, Liu GH and Qu J: Mitochondrial sirtuins, metabolism, and aging. J Genet Genomics. 49:287–298. 2022. View Article : Google Scholar

66 

Dikalov S and Dikalova A: Mitochondrial deacetylase Sirt3 in vascular dysfunction and hypertension. Curr Opin Nephrol Hypertens. 31:151–156. 2022. View Article : Google Scholar : PubMed/NCBI

67 

Shen Y, Wu Q, Shi J and Zhou S: Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson's disease. Biomed Pharmacother. 132:1109282020. View Article : Google Scholar : PubMed/NCBI

68 

Wang X, Shen T, Lian J, Deng K, Qu C, Li E, Li G, Ren Y, Wang Z, Jiang Z, et al: Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway. Mol Med. 29:1372023. View Article : Google Scholar : PubMed/NCBI

69 

Xie X, Xu Q and Zhou D: Sirtuin-3 activates the mitochondrial unfolded protein response and reduces cerebral ischemia/reperfusion injury. Int J Biol Sci. 19:4327–4339. 2023. View Article : Google Scholar

70 

Zhao H, Luo Y, Chen L, Zhang Z, Shen C, Li Y and Xu R: Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/β-catenin pathway and blocking mitochondrial fission. Cell Stress Chaperones. 23:1079–1092. 2018. View Article : Google Scholar : PubMed/NCBI

71 

Zhu W, Lian N, Wang J, Zhao F, Liu B, Sheng J, Zhang C, Zhou X, Gao W, Xie C, et al: Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity. Chin Med. 19:852024. View Article : Google Scholar : PubMed/NCBI

72 

Cong L, Liu X, Bai Y, Qin Q, Zhao L, Shi Y, Bai Y and Guo Z: Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression. Biol Res. 56:622023. View Article : Google Scholar

73 

Chen ML, Zhu XH, Ran L, Lang HD, Yi L and Mi MT: Trimethylamine-N-Oxide induces vascular inflammation by activating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway. J Am Heart Assoc. 6:e0063472017. View Article : Google Scholar : PubMed/NCBI

74 

Zhang Y, Liu Y, Hou M, Xia X, Liu J, Xu Y, Shi Q, Zhang Z, Wang L, Shen Y, et al: Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3-COX4I2 Axis Attenuates Osteoarthritis Progression. Adv Sci (Weinh). 10:e22061442023. View Article : Google Scholar : PubMed/NCBI

75 

Chang Y, Wang C, Zhu J, Zheng S, Sun S, Wu Y, Jiang X, Li L, Ma R and Li G: SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes. J Transl Med. 21:4942023. View Article : Google Scholar : PubMed/NCBI

76 

Zheng X, Gao J, Zhao M, Han L, Zhang D, Wang K and Cui J: Honokiol attenuates mitochondrial fission and cell apoptosis by activating Sirt3 in intracerebral hemorrhage. Chin Med J (Engl). 136:719–731. 2023. View Article : Google Scholar : PubMed/NCBI

77 

Yao Y, Ren Z, Yang R, Mei Y, Dai Y, Cheng Q, Xu C, Xu X, Wang S, Kim KM, et al: Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway. Cell Biosci. 12:1802022. View Article : Google Scholar : PubMed/NCBI

78 

Li Y, Feng L, Xie D, Luo Y, Lin M, Gao J, Zhang Y, He Z, Zhu YZ and Gong Q: Icariside II mitigates myocardial infarction by balancing mitochondrial dynamics and reducing oxidative stress through the activation of Nrf2/SIRT3 signaling pathway. Eur J Pharmacol. 956:1759872023. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu K, Wang Q, Zhang Z, Luo W, Peng J, Ma X, Wang L, Xie C and Guo W: Honokiol ameliorates pyroptosis in intestinal ischemia‑reperfusion injury by regulating the SIRT3‑mediated NLRP3 inflammasome. Int J Mol Med 55: 96, 2025.
APA
Wu, K., Wang, Q., Zhang, Z., Luo, W., Peng, J., Ma, X. ... Guo, W. (2025). Honokiol ameliorates pyroptosis in intestinal ischemia‑reperfusion injury by regulating the SIRT3‑mediated NLRP3 inflammasome. International Journal of Molecular Medicine, 55, 96. https://doi.org/10.3892/ijmm.2025.5537
MLA
Wu, K., Wang, Q., Zhang, Z., Luo, W., Peng, J., Ma, X., Wang, L., Xie, C., Guo, W."Honokiol ameliorates pyroptosis in intestinal ischemia‑reperfusion injury by regulating the SIRT3‑mediated NLRP3 inflammasome". International Journal of Molecular Medicine 55.6 (2025): 96.
Chicago
Wu, K., Wang, Q., Zhang, Z., Luo, W., Peng, J., Ma, X., Wang, L., Xie, C., Guo, W."Honokiol ameliorates pyroptosis in intestinal ischemia‑reperfusion injury by regulating the SIRT3‑mediated NLRP3 inflammasome". International Journal of Molecular Medicine 55, no. 6 (2025): 96. https://doi.org/10.3892/ijmm.2025.5537
Copy and paste a formatted citation
x
Spandidos Publications style
Wu K, Wang Q, Zhang Z, Luo W, Peng J, Ma X, Wang L, Xie C and Guo W: Honokiol ameliorates pyroptosis in intestinal ischemia‑reperfusion injury by regulating the SIRT3‑mediated NLRP3 inflammasome. Int J Mol Med 55: 96, 2025.
APA
Wu, K., Wang, Q., Zhang, Z., Luo, W., Peng, J., Ma, X. ... Guo, W. (2025). Honokiol ameliorates pyroptosis in intestinal ischemia‑reperfusion injury by regulating the SIRT3‑mediated NLRP3 inflammasome. International Journal of Molecular Medicine, 55, 96. https://doi.org/10.3892/ijmm.2025.5537
MLA
Wu, K., Wang, Q., Zhang, Z., Luo, W., Peng, J., Ma, X., Wang, L., Xie, C., Guo, W."Honokiol ameliorates pyroptosis in intestinal ischemia‑reperfusion injury by regulating the SIRT3‑mediated NLRP3 inflammasome". International Journal of Molecular Medicine 55.6 (2025): 96.
Chicago
Wu, K., Wang, Q., Zhang, Z., Luo, W., Peng, J., Ma, X., Wang, L., Xie, C., Guo, W."Honokiol ameliorates pyroptosis in intestinal ischemia‑reperfusion injury by regulating the SIRT3‑mediated NLRP3 inflammasome". International Journal of Molecular Medicine 55, no. 6 (2025): 96. https://doi.org/10.3892/ijmm.2025.5537
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team