Open Access

Developments in the connection between epithelial‑mesenchymal transition and endoplasmic reticulum stress (Review)

  • Authors:
    • Hongyu Chai
    • Shun Yao
    • Ya Gao
    • Qian Hu
    • Wei Su
  • View Affiliations

  • Published online on: May 5, 2025     https://doi.org/10.3892/ijmm.2025.5543
  • Article Number: 102
  • Copyright: © Chai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Endoplasmic reticulum stress (ERS) and epithelial‑mesenchymal transition (EMT) have important roles in fibrosis and tumour development. Moderate ERS activates cellular defence mechanisms in response to noxious stimuli; however, sustained or overly strong ERS induces apoptosis. In this disease process, EMT induces epithelial cells to acquire the ability to migrate and invade. Reportedly, ERS directly or indirectly regulates EMT processes through multiple mechanisms (such as key transcription factors, signalling pathways, ferroptosis, autophagy and oxidative stress), and both processes form a complex network of interactions. Given the critical roles of ERS and EMT in disease, targeted intervention of these two processes has emerged as a potential therapeutic strategy. In the present study, the molecular interaction mechanism of ERS and EMT was systematically explored, research progress in fibrotic and neoplastic diseases was reviewed and the potential application prospects of related targeted therapies were examined, which may provide new ideas for the development of drugs to reverse fibrosis and treat tumours.
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July-2025
Volume 56 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Chai H, Yao S, Gao Y, Hu Q and Su W: Developments in the connection between epithelial‑mesenchymal transition and endoplasmic reticulum stress (Review). Int J Mol Med 56: 102, 2025.
APA
Chai, H., Yao, S., Gao, Y., Hu, Q., & Su, W. (2025). Developments in the connection between epithelial‑mesenchymal transition and endoplasmic reticulum stress (Review). International Journal of Molecular Medicine, 56, 102. https://doi.org/10.3892/ijmm.2025.5543
MLA
Chai, H., Yao, S., Gao, Y., Hu, Q., Su, W."Developments in the connection between epithelial‑mesenchymal transition and endoplasmic reticulum stress (Review)". International Journal of Molecular Medicine 56.1 (2025): 102.
Chicago
Chai, H., Yao, S., Gao, Y., Hu, Q., Su, W."Developments in the connection between epithelial‑mesenchymal transition and endoplasmic reticulum stress (Review)". International Journal of Molecular Medicine 56, no. 1 (2025): 102. https://doi.org/10.3892/ijmm.2025.5543