Open Access

Lactate and lactylation in the kidneys: Current advances and prospects (Review)

  • Authors:
    • Xu Li
    • Lan Hu
    • Qin Hu
    • Hua Jin
  • View Affiliations

  • Published online on: June 5, 2025     https://doi.org/10.3892/ijmm.2025.5562
  • Article Number: 121
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lactate, traditionally overlooked as a glycolytic byproduct, has recently been recognized for its significant biological roles. The normal kidney plays an essential role in maintaining systemic glucose and lactate homeostasis. Lactylation, as a new epigenetic modification, influences the initiation and progression of kidney diseases through the regulation of gene transcription and cellular metabolism. The present review summarizes current perspectives on the physiological functions of lactate and its renal metabolism, analyzes the roles of lactate and lactylation in acute kidney injury, diabetic nephropathy and chronic kidney disease, and proposes that targeted modulation of lactate metabolism may represent a promising therapeutic strategy for kidney disorders, thereby providing a foundation for future investigations.
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August-2025
Volume 56 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Li X, Hu L, Hu Q and Jin H: Lactate and lactylation in the kidneys: Current advances and prospects (Review). Int J Mol Med 56: 121, 2025.
APA
Li, X., Hu, L., Hu, Q., & Jin, H. (2025). Lactate and lactylation in the kidneys: Current advances and prospects (Review). International Journal of Molecular Medicine, 56, 121. https://doi.org/10.3892/ijmm.2025.5562
MLA
Li, X., Hu, L., Hu, Q., Jin, H."Lactate and lactylation in the kidneys: Current advances and prospects (Review)". International Journal of Molecular Medicine 56.2 (2025): 121.
Chicago
Li, X., Hu, L., Hu, Q., Jin, H."Lactate and lactylation in the kidneys: Current advances and prospects (Review)". International Journal of Molecular Medicine 56, no. 2 (2025): 121. https://doi.org/10.3892/ijmm.2025.5562