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Article Open Access

Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells

  • Authors:
    • Jianping He
    • Chenxi Feng
    • Yaohan Xu
    • Siji Chen
    • Jie Chen
    • Jingying Pan
    • Yinjing Song
    • Hao Cheng
    • Jiang Zhu
    • Jie Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China, Department of Clinical laboratory, Zhejiang Hospital, Hangzhou, Zhejiang 310013, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 122
    |
    Published online on: June 10, 2025
       https://doi.org/10.3892/ijmm.2025.5563
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Abstract

Psoriasis, the most common inflammatory skin disease, is marked by excessive proliferation of keratinocytes and infiltration of immune cells into the epidermis. Current treatments, particularly biologics targeting the IL‑23/IL‑17 axis, demonstrate excellent efficacy, but issues of recurrence and side effects persist. Therefore, it is essential to identify safer and more effective alternatives. Lobetyolin (LBT), a key component of polyacetylenes in Codonopsis pilosula, exhibits potent antioxidant and antitumor properties, yet its potential for treating psoriasis remains unexplored. In the present study, it was found that topical treatment with LBT significantly inhibits psoriasis in mice and maintains skin homeostasis during disease progression by regulating genes associated with keratinocyte proliferation and differentiation, enhancing the PPAR signaling pathway, and upregulating genes and metabolites involved in linoleic acid metabolism. Additionally, LBT suppressed gene expression linked to cytokine activity as well as the Il17, Tnf and MAPK signaling pathways in IMQ‑treated dendritic cells (DCs). These findings underscored LBT's efficacy in reducing IMQ‑induced psoriasis‑like skin inflammation by preserving skin homeostasis and inhibiting inflammatory cytokines in DCs. The present results suggested that topically applied LBT could serve as a promising drug candidate for psoriasis treatment or as an adjunct to biologic therapies to prevent disease relapse.
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Copy and paste a formatted citation
Spandidos Publications style
He J, Feng C, Xu Y, Chen S, Chen J, Pan J, Song Y, Cheng H, Zhu J, Zhu J, Zhu J, et al: Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells. Int J Mol Med 56: 122, 2025.
APA
He, J., Feng, C., Xu, Y., Chen, S., Chen, J., Pan, J. ... Zhu, J. (2025). Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells. International Journal of Molecular Medicine, 56, 122. https://doi.org/10.3892/ijmm.2025.5563
MLA
He, J., Feng, C., Xu, Y., Chen, S., Chen, J., Pan, J., Song, Y., Cheng, H., Zhu, J., Zhu, J."Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells". International Journal of Molecular Medicine 56.2 (2025): 122.
Chicago
He, J., Feng, C., Xu, Y., Chen, S., Chen, J., Pan, J., Song, Y., Cheng, H., Zhu, J., Zhu, J."Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells". International Journal of Molecular Medicine 56, no. 2 (2025): 122. https://doi.org/10.3892/ijmm.2025.5563
Copy and paste a formatted citation
x
Spandidos Publications style
He J, Feng C, Xu Y, Chen S, Chen J, Pan J, Song Y, Cheng H, Zhu J, Zhu J, Zhu J, et al: Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells. Int J Mol Med 56: 122, 2025.
APA
He, J., Feng, C., Xu, Y., Chen, S., Chen, J., Pan, J. ... Zhu, J. (2025). Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells. International Journal of Molecular Medicine, 56, 122. https://doi.org/10.3892/ijmm.2025.5563
MLA
He, J., Feng, C., Xu, Y., Chen, S., Chen, J., Pan, J., Song, Y., Cheng, H., Zhu, J., Zhu, J."Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells". International Journal of Molecular Medicine 56.2 (2025): 122.
Chicago
He, J., Feng, C., Xu, Y., Chen, S., Chen, J., Pan, J., Song, Y., Cheng, H., Zhu, J., Zhu, J."Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells". International Journal of Molecular Medicine 56, no. 2 (2025): 122. https://doi.org/10.3892/ijmm.2025.5563
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