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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October-2025 Volume 56 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Correction Open Access

[Corrigendum] Epithelial‑mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells

  • Authors:
    • Pei Zhang
    • Hao Liu
    • Fei Xia
    • Qian Wen Zhang
    • Yuan Yuan Zhang
    • Qing Zhao
    • Zhen Hua Chao
    • Zhi Wen Jiang
    • Chen Chen Jiang
  • View Affiliations / Copyright

    Affiliations: Faculty of Pharmacy, Bengbu Medical College, Anhui Engineering Technology Research Center of Biochemical Pharmaceuticals, Bengbu, Anhui 233030, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 150
    |
    Published online on: July 21, 2025
       https://doi.org/10.3892/ijmm.2025.5591
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Article

View Figures

Figure 1

Cisplatin (DDP)-treated CNE2 cells
underwent an epithelial-mesenchymal transition (EMT)-like
transformation. (A) Cell morphology was observed by microscopy at
x200 magnification. Parental CNE2 cells showed an epithelioid,
cobblestone appearance, similar to HNE1 cells. By contrast, the
morphology of CNE2/DDP cells was of mixed type, showing an
epithelioid, long, spindle/fibroblastic pattern with pseudopodia
and an unorganized growth pattern. (B) Expression levels of the
EMT-related proteins, E-cadherin, β-catenin, vimentin, fibronectin
and matrix metalloproteinase (MMP)-9, were determined by western
blot analysis. The downregulation of E-cadherin and β-catenin and
upregulation of vimentin, fibronectin and MMP-9 was observed in
CNE2/DDP cells. (C) mRNA expression levels of E-cadherin,
β-catenin, vimentin, fibronectin and MMP-9 genes were analyzed by
qRT-PCR (means ± SEM, n=3, *P<0.05 compared with the
parental CNE2 cells). (D) Increased protein levels of the
EMT-related transcription factors, Snail, Slug, Twist and zinc
finger E-box binding homeobox 1 (ZEB1), were determined by western
blot analysis. (E) mRNA expression levels for genes coding for the
EMT-related transcription factors, Snail, Slug, Twist and ZEB1,
were analyzed by qRT-PCR (means ± SEM, n=3, *P<0.05
compared with parental CNE2 cells).

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Copy and paste a formatted citation
Spandidos Publications style
Zhang P, Liu H, Xia F, Zhang QW, Zhang YY, Zhao Q, Chao ZH, Jiang ZW and Jiang CC: [Corrigendum] Epithelial‑mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells. Int J Mol Med 56: 150, 2025.
APA
Zhang, P., Liu, H., Xia, F., Zhang, Q.W., Zhang, Y.Y., Zhao, Q. ... Jiang, C.C. (2025). [Corrigendum] Epithelial‑mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells. International Journal of Molecular Medicine, 56, 150. https://doi.org/10.3892/ijmm.2025.5591
MLA
Zhang, P., Liu, H., Xia, F., Zhang, Q. W., Zhang, Y. Y., Zhao, Q., Chao, Z. H., Jiang, Z. W., Jiang, C. C."[Corrigendum] Epithelial‑mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells". International Journal of Molecular Medicine 56.4 (2025): 150.
Chicago
Zhang, P., Liu, H., Xia, F., Zhang, Q. W., Zhang, Y. Y., Zhao, Q., Chao, Z. H., Jiang, Z. W., Jiang, C. C."[Corrigendum] Epithelial‑mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells". International Journal of Molecular Medicine 56, no. 4 (2025): 150. https://doi.org/10.3892/ijmm.2025.5591
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang P, Liu H, Xia F, Zhang QW, Zhang YY, Zhao Q, Chao ZH, Jiang ZW and Jiang CC: [Corrigendum] Epithelial‑mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells. Int J Mol Med 56: 150, 2025.
APA
Zhang, P., Liu, H., Xia, F., Zhang, Q.W., Zhang, Y.Y., Zhao, Q. ... Jiang, C.C. (2025). [Corrigendum] Epithelial‑mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells. International Journal of Molecular Medicine, 56, 150. https://doi.org/10.3892/ijmm.2025.5591
MLA
Zhang, P., Liu, H., Xia, F., Zhang, Q. W., Zhang, Y. Y., Zhao, Q., Chao, Z. H., Jiang, Z. W., Jiang, C. C."[Corrigendum] Epithelial‑mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells". International Journal of Molecular Medicine 56.4 (2025): 150.
Chicago
Zhang, P., Liu, H., Xia, F., Zhang, Q. W., Zhang, Y. Y., Zhao, Q., Chao, Z. H., Jiang, Z. W., Jiang, C. C."[Corrigendum] Epithelial‑mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells". International Journal of Molecular Medicine 56, no. 4 (2025): 150. https://doi.org/10.3892/ijmm.2025.5591
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