|
1
|
Baker P, Huang C, Radi R, Moll SB, Jules E
and Arbiser JL: Skin barrier function: The interplay of physical,
chemical, and immunologic properties. Cells. 12:27452023.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Zhang C, Merana GR, Harris-Tryon T and
Scharschmidt TC: Skin immunity: Dissecting the complex biology of
our Body's outer barrier. Mucosal Immunol. 15:551–561. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Hsu YC and Fuchs E: Building and
Maintaining the Skin. Cold Spring Harb Perspect Biol.
14:a0408402022. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Harris-Tryon TA and Grice EA: Microbiota
and maintenance of skin barrier function. Science. 376:940–945.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Woodby B, Penta K, Pecorelli A, Lila MA
and Valacchi G: Skin Health from the inside out. Annu Rev Food Sci
Technol. 11:235–254. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Talbott HE, Mascharak S, Griffin M, Wan DC
and Longaker MT: Wound healing, fibroblast heterogeneity, and
fibrosis. Cell Stem Cell. 29:1161–1180. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Uberoi A, McCready-Vangi A and Grice EA:
The wound microbiota: Microbial mechanisms of impaired wound
healing and infection. Nat Rev Microbiol. 22:507–521. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Peña OA and Martin P: Cellular and
molecular mechanisms of skin wound healing. Nat Rev Mol Cell Biol.
25:599–616. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Smith J and Rai V: Novel factors
regulating proliferation, migration, and differentiation of
fibroblasts, keratinocytes, and vascular smooth muscle cells during
wound healing. Biomedicines. 12:19392024. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Jeschke MG, Wood FM, Middelkoop E, Bayat
A, Teot L, Ogawa R and Gauglitz GG: Scars. Nat Rev Dis Primers.
9:642023. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Yu FSX, Lee PSY, Yang L, Gao N, Zhang Y,
Ljubimov AV, Yang E, Zhou Q and Xie L: The impact of sensory
neuropathy and inflammation on epithelial wound healing in diabetic
corneas. Prog Retin Eye Res. 89:1010392022. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Canchy L, Kerob D, Demessant A and Amici
JM: Wound healing and microbiome, an unexpected relationship. J Eur
Acad Dermatol Venereol. 37 (Suppl 3):S7–S15. 2023. View Article : Google Scholar
|
|
13
|
Lacina L, Kolář M, Pfeiferová L, Gál P and
Smetana K: Wound healing: Insights into autoimmunity, ageing, and
cancer ecosystems through inflammation and IL-6 modulation. Front
Immunol. 15:14035702024. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Wen Q, Liu D, Wang X, Zhang Y, Fang S, Qiu
X and Chen Q: A systematic review of ozone therapy for treating
chronically refractory wounds and ulcers. Int Wound J. 19:853–870.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Liu Y, Liu Y, He W, Mu X, Wu X, Deng J and
Nie X: Fibroblasts: Immunomodulatory factors in refractory diabetic
wound healing. Front Immunol. 13:9182232022. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Martinengo L, Olsson M, Bajpai R, Soljak
M, Upton Z, Schmidtchen A, Car J and Järbrink K: Prevalence of
chronic wounds in the general population: Systematic review and
meta-analysis of observational studies. Ann Epidemiol. 29:8–15.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Luo Y, Liu C, Li C, Jin M, Pi L and Jin Z:
The incidence of lower extremity amputation and its associated risk
factors in patients with diabetic foot ulcers: A meta-analysis. Int
Wound J. 21:e149312024. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Yao Y, Chen L and Qian Y: Age
characteristics of patients with type 2 diabetic foot ulcers and
predictive risk factors for lower limb amputation: A
Population-based retrospective study. J Diabetes Res.
2024:23803372024. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Kapp S, Miller C and Santamaria N: The
quality of life of people who have chronic wounds and who
self-treat. J Clin Nurs. 27:182–192. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Yi SV: Epigenetics research in
evolutionary biology: Perspectives on timescales and mechanisms.
Mol Biol Evol. 41:msae1702024. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Martin CL, Ghastine L, Lodge EK, Dhingra R
and Ward-Caviness CK: Understanding health inequalities through the
lens of social epigenetics. Annu Rev Public Health. 43:235–254.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Peixoto P, Cartron PF, Serandour AA and
Hervouet E: From 1957 to nowadays: A brief history of epigenetics.
Int J Mol Sci. 21:75712020. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Chen LL and Kim VN: Small and long
non-coding RNAs: Past, present, and future. Cell. 187:6451–6485.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Cedar H and Bergman Y: Linking DNA
methylation and histone modification: Patterns and paradigms. Nat
Rev Genet. 10:295–304. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Wiener D and Schwartz S: The
epitranscriptome beyond m6A. Nat Rev Genet. 22:119–131. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Bates SE: Epigenetic therapies for cancer.
N Engl J Med. 383:650–663. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Hogg SJ, Beavis PA, Dawson MA and
Johnstone RW: Targeting the epigenetic regulation of antitumour
immunity. Nat Rev Drug Discov. 19:776–800. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Plutzky J: Epigenetic therapeutics for
cardiovascular disease: Writing, erasing, reading, and maybe
forgetting. JAMA. 323:1557–1558. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Nativio R, Lan Y, Donahue G, Sidoli S,
Berson A, Srinivasan AR, Shcherbakova O, Amlie-Wolf A, Nie J, Cui
X, et al: An integrated multi-omics approach identifies epigenetic
alterations associated with Alzheimer's disease. Nat Genet.
52:1024–1035. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Lucas MC and Novoa EM: Long-read
sequencing in the era of epigenomics and epitranscriptomics. Nat
Methods. 20:25–29. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Zhang Q, Dong L, Gong S and Wang T:
Unraveling the landscape of m6A RNA methylation in wound healing
and scars. Cell Death Discov. 10:4582024. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Singh K, Rustagi Y, Abouhashem AS, Tabasum
S, Verma P, Hernandez E, Pal D, Khona DK, Mohanty SK, Kumar M, et
al: Genome-wide DNA hypermethylation opposes healing in patients
with chronic wounds by impairing epithelial-mesenchymal transition.
J Clin Invest. 132:e1572792022. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Luan A, Hu MS, Leavitt T, Brett EA, Wang
KC, Longaker MT and Wan DC: Noncoding RNAs in wound healing: A new
and vast frontier. Adv Wound Care (New Rochelle). 7:19–27. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Luo G, Jing X, Yang S, Peng D, Dong J, Li
L, Reinach PS and Yan D: DNA methylation regulates corneal
epithelial wound healing by targeting miR-200a and CDKN2B. Invest
Ophthalmol Vis Sci. 60:650–660. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zhou R, Wang Q, Zeng S, Liang Y and Wang
D: METTL14-mediated N6-methyladenosine modification of
Col17a1/Itgα6/Itgβ4 governs epidermal homeostasis. J Dermatol Sci.
112:138–147. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Hong YK, Chang YH, Lin YC, Chen B, Guevara
BEK and Hsu CK: Inflammation in wound healing and pathological
scarring. Adv Wound Care (New Rochelle). 12:288–300. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Stevenson AW, Melton PE, Moses EricK,
Wallace HJ, Wood FM, Rea S, Danielsen PL, Alghamdi M, Hortin N,
Borowczyk J, et al: A Methylome and Transcriptome analysis of
normal human scar cells reveals a role for FOXF2 in scar
maintenance. J Invest Dermatol. 142:1489–1498.e12. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Lin CX, Chen ZJ, Peng QL, Xiang KR, Xiao
DQ, Chen RX, Cui T, Huang YS and Liu HW: The m6A-methylated mRNA
pattern and the activation of the Wnt signaling pathway under the
hyper-m6A-modifying condition in the keloid. Front Cell Dev Biol.
10:9473372022. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Su L and Han J: Non-coding RNAs in
hypertrophic scars and keloids: Current research and clinical
relevance: A review. Int J Biol Macromol. 256:1283342024.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Tao Y, Zhang Q, Wang H, Yang X and Mu H:
Alternative splicing and related RNA binding proteins in human
health and disease. Signal Transduct Target Ther. 9:262024.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Zhu ZM, Huo FC, Zhang J, Shan HJ and Pei
DS: Crosstalk between m6A modification and alternative splicing
during cancer progression. Clin Transl Med. 13:e14602023.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Chen Y, Hong T, Wang S, Mo J, Tian T and
Zhou X: Epigenetic modification of nucleic acids: From basic
studies to medical applications. Chem Soc Rev. 46:2844–2872. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Wang X, Zhao BS, Roundtree IA, Lu Z, Han
D, Ma H, Weng X, Chen K, Shi H and He C: N(6)-methyladenosine
modulates messenger RNA translation efficiency. Cell.
161:1388–1399. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Chen Y, Ren B, Yang J, Wang H, Yang G, Xu
R, You L and Zhao Y: The role of histone methylation in the
development of digestive cancers: A potential direction for cancer
management. Signal Transduct Target Ther. 5:1432020. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Lorzadeh A, Romero-Wolf M, Goel A and
Jadhav U: Epigenetic regulation of intestinal stem cells and
disease: A balancing Act of DNA and histone methylation.
Gastroenterology. 160:2267–2282. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Venkatesh S and Workman JL: Histone
exchange, chromatin structure and the regulation of transcription.
Nat Rev Mol Cell Biol. 16:178–189. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Bannister AJ and Kouzarides T: Regulation
of chromatin by histone modifications. Cell Res. 21:381–395. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Li Z, Gadue P, Chen K, Jiao Y, Tuteja G,
Schug J, Li W and Kaestner KH: Foxa2 and H2A.Z mediate nucleosome
depletion during embryonic stem cell differentiation. Cell.
151:1608–1616. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Jambhekar A, Dhall A and Shi Y: Roles and
regulation of histone methylation in animal development. Nat Rev
Mol Cell Biol. 20:625–641. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Greer EL and Shi Y: Histone methylation: A
dynamic mark in health, disease and inheritance. Nat Rev Genet.
13:343–357. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Martin C and Zhang Y: The diverse
functions of histone lysine methylation. Nat Rev Mol Cell Biol.
6:838–849. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Lachner M and Jenuwein T: The many faces
of histone lysine methylation. Curr Opin Cell Biol. 14:286–298.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Klose RJ and Zhang Y: Regulation of
histone methylation by demethylimination and demethylation. Nat Rev
Mol Cell Biol. 8:307–318. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Lin Z, Rong B, Lyu R, Zheng Y, Chen Y, Yan
J, Wu M, Gao X, Tang F, Lan F and Tong MH: SETD1B-mediated broad
H3K4me3 controls proper temporal patterns of gene expression
critical for spermatid development. Cell Res. 35:345–361. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Yuan F, He C, Gong X, Zeng G, Qin X, Deng
Z, Shen X and Hu Y: H3K36me3 regulates subsets of photosynthesis
genes in Sorghum bicolor potentially by counteracting H3K27me3 or
H2A.Z. Plant Physiol Biochem. 223:1098312025. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Chiang CY, Fan S, Zheng H, Guo W, Zheng Z,
Sun Y, Zhong C, Zeng J, Li S, Zhang M, et al: Methylation of KRAS
by SETD7 promotes KRAS degradation in non-small cell lung cancer.
Cell Rep. 42:1130032023. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Bichmann M, Prat Oriol N, Ercan-Herbst E,
Schöndorf DC, Gomez Ramos B, Schwärzler V, Neu M, Schlüter A, Wang
X, Jin L, et al: SETD7-mediated monomethylation is enriched on
soluble Tau in Alzheimer's disease. Mol Neurodegener. 16:462021.
View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Guo Y, Zhao S and Wang GG: Polycomb gene
silencing mechanisms: PRC2 chromatin targeting, H3K27me3 ‘Readout’,
and phase separation-based compaction. Trends Genet. 37:547–565.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Klemm SL, Shipony Z and Greenleaf WJ:
Chromatin accessibility and the regulatory epigenome. Nat Rev
Genet. 20:207–220. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Lawrence M, Daujat S and Schneider R:
Lateral thinking: How histone modifications regulate gene
expression. Trends Genet. 32:42–56. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Michalak EM, Burr ML, Bannister AJ and
Dawson MA: The roles of DNA, RNA and histone methylation in ageing
and cancer. Nat Rev Mol Cell Biol. 20:573–589. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Cali CP, Park DS and Lee EB: Targeted DNA
methylation of neurodegenerative disease genes via homology
directed repair. Nucleic Acids Res. 47:11609–11622. 2019.PubMed/NCBI
|
|
63
|
Shi Y, Zhang H, Huang S, Yin L, Wang F,
Luo P and Huang H: Epigenetic regulation in cardiovascular disease:
Mechanisms and advances in clinical trials. Signal Transduct Target
Ther. 7:2002022. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Gujral P, Mahajan V, Lissaman AC and
Ponnampalam AP: Histone acetylation and the role of histone
deacetylases in normal cyclic endometrium. Reprod Biol Endocrinol.
18:842020. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Shvedunova M and Akhtar A: Modulation of
cellular processes by histone and non-histone protein acetylation.
Nat Rev Mol Cell Biol. 23:329–349. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Allfrey VG, Faulkner R and Mirsky AE:
Acetylation and methylation of histones and their possible role in
the regulation of RNA synthesis. Proc Natl Acad Sci USA.
51:786–794. 1964. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Jaffe IZ: Histone Acetyltransferases in
smooth muscle cell phenotype switching: Redundant no longer.
Circulation. 145:1738–1740. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Chen Q, Yang B, Liu X, Zhang XD, Zhang L
and Liu T: Histone acetyltransferases CBP/p300 in tumorigenesis and
CBP/p300 inhibitors as promising novel anticancer agents.
Theranostics. 12:4935–4948. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Yuan H and Marmorstein R: Histone
acetyltransferases: Rising ancient counterparts to protein kinases.
Biopolymers. 99:98–111. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Yiew KH, Chatterjee TK, Hui DY and
Weintraub NL: Histone deacetylases and cardiometabolic diseases.
Arterioscler Thromb Vasc Biol. 35:1914–1919. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Barneda-Zahonero B and Parra M: Histone
deacetylases and cancer. Mol Oncol. 6:579–589. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Seto E and Yoshida M: Erasers of histone
acetylation: The histone deacetylase enzymes. Cold Spring Harb
Perspect Biol. 6:a0187132014. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Liebner T, Kilic S, Walter J, Aibara H,
Narita T and Choudhary C: Acetylation of histones and non-histone
proteins is not a mere consequence of ongoing transcription. Nat
Commun. 15:49622024. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Kurat CF, Lambert JP, Petschnigg J,
Friesen H, Pawson T, Rosebrock A, Gingras AC, Fillingham J and
Andrews B: Cell cycle-regulated oscillator coordinates core histone
gene transcription through histone acetylation. Proc Natl Acad Sci
USA. 111:14124–14129. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Sutendra G, Kinnaird A, Dromparis P,
Paulin R, Stenson TH, Haromy A, Hashimoto K, Zhang N, Flaim E and
Michelakis ED: A nuclear pyruvate dehydrogenase complex is
important for the generation of acetyl-CoA and histone acetylation.
Cell. 158:84–97. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Zhou W, Zhao T, Du J, Ji G, Li X, Ji S,
Tian W, Wang X and Hao A: TIGAR promotes neural stem cell
differentiation through acetyl-CoA-mediated histone acetylation.
Cell Death Dis. 10:1982019. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Kumar V, Thakur JK and Prasad M: Histone
acetylation dynamics regulating plant development and stress
responses. Cell Mol Life Sci. 78:4467–4486. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Liu X, Guo C, Leng T, Fan Z, Mai J, Chen
J, Xu J, Li Q, Jiang B, Sai K, et al: Differential regulation of
H3K9/H3K14 acetylation by small molecules drives
neuron-fate-induction of glioma cell. Cell Death Dis. 14:1422023.
View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Cui M, Cheng C and Zhang L:
High-throughput proteomics: A methodological mini-review. Lab
Invest. 102:1170–1181. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Sidoli S, Lopes M, Lund PJ, Goldman N,
Fasolino M, Coradin M, Kulej K, Bhanu NV, Vahedi G and Garcia BA: A
mass spectrometry-based assay using metabolic labeling to rapidly
monitor chromatin accessibility of modified histone proteins. Sci
Rep. 9:136132019. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Yao W, Hu X and Wang X: Crossing
epigenetic frontiers: The intersection of novel histone
modifications and diseases. Signal Transduct Target Ther.
9:2322024. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Moore LD, Le T and Fan G: DNA methylation
and its basic function. Neuropsychopharmacology. 38:23–38. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Almatarneh MH, Kayed GG, Abbad SSA,
Alsunaidi ZHA, Al-Sheraideh MS and Zhao Y: Mechanistic study on DNA
mutation of the cytosine methylation reaction at C5 position.
Arabian J Chemistry. 15:1039562022. View Article : Google Scholar
|
|
84
|
Li E and Zhang Y: DNA methylation in
mammals. Cold Spring Harb Perspect Biol. 6:a0191332014. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Meng H, Cao Y, Qin J, Song X, Zhang Q, Shi
Y and Cao L: DNA methylation, its mediators and genome integrity.
Int J Biol Sci. 11:604–617. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Angeloni A and Bogdanovic O: Enhancer DNA
methylation: Implications for gene regulation. Essays Biochem.
63:707–715. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Feinberg AP, Cui H and Ohlsson R: DNA
methylation and genomic imprinting: Insights from cancer into
epigenetic mechanisms. Semin Cancer Biol. 12:389–398. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Law JA and Jacobsen SE: Establishing,
maintaining and modifying DNA methylation patterns in plants and
animals. Nat Rev Genet. 11:204–220. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Yan R, Cheng X, Gu C, Xu Y, Long X, Zhai
J, Sun F, Qian J, Du Y, Wang H, et al: Dynamics of DNA
hydroxymethylation and methylation during mouse embryonic and
germline development. Nat Genet. 55:130–143. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Nishiyama A and Nakanishi M: Navigating
the DNA methylation landscape of cancer. Trends Genet.
37:1012–1027. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Kausar S, Abbas MN and Cui H: A review on
the DNA methyltransferase family of insects: Aspect and prospects.
Int J Biol Macromol. 186:289–302. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Espada J, Ballestar E, Fraga MF,
Villar-Garea A, Juarranz A, Stockert JC, Robertson KD, Fuks F and
Esteller M: Human DNA methyltransferase 1 is required for
maintenance of the histone H3 modification pattern. J Biol Chem.
279:37175–37184. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Okano M, Bell DW, Haber DA and Li E: DNA
methyltransferases Dnmt3a and Dnmt3b are essential for de novo
methylation and mammalian development. Cell. 99:247–257. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Kohli RM and Zhang Y: TET enzymes, TDG and
the dynamics of DNA demethylation. Nature. 502:472–479. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Shi J, Xu J, Chen YE, Li JS, Cui Y, Shen
L, Li JJ and Li W: The concurrence of DNA methylation and
demethylation is associated with transcription regulation. Nat
Commun. 12:52852021. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Stefansson OA, Sigurpalsdottir BD,
Rognvaldsson S, Halldorsson GH, Juliusson K, Sveinbjornsson G,
Gunnarsson B, Beyter D, Jonsson H, Gudjonsson SA, et al: The
correlation between CpG methylation and gene expression is driven
by sequence variants. Nat Genet. 56:1624–1631. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Ishidoya M, Fujita T, Tasaka S and Fujii
H: Real-time MBDi-RPA using methyl-CpG binding protein 2: A
real-time detection method for simple and rapid estimation of CpG
methylation status. Anal Chim Acta. 1302:3424862024. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Esteller M: CpG island hypermethylation
and tumor suppressor genes: A booming present, a brighter future.
Oncogene. 21:5427–5440. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Cilleros-Portet A, Lesseur C, Marí S,
Cosin-Tomas M, Lozano M, Irizar A, Burt A, García-Santisteban I,
Garrido-Martín D, Escaramís G, et al: Potentially causal
associations between placental DNA methylation and schizophrenia
and other neuropsychiatric disorders. Nat Commun. 16:24312025.
View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Hop PJ, Zwamborn RAJ, Hannon E, Shireby
GL, Nabais MF, Walker EM, van Rheenen W, van Vugt JJFA, Dekker AM,
Westeneng HJ, et al: Genome-wide study of DNA methylation shows
alterations in metabolic, inflammatory, and cholesterol pathways in
ALS. Sci Transl Med. 14:eabj02642022. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Li X, Wang J, Wang L, Gao Y, Feng G, Li G,
Zou J, Yu M, Li YF, Liu C, et al: Lipid metabolism dysfunction
induced by age-dependent DNA methylation accelerates aging. Signal
Transduct Target Ther. 7:1622022. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
McAllan L, Baranasic D, Villicaña S, Brown
S, Zhang W, Lehne B, Adamo M, Jenkinson A, Elkalaawy M, Mohammadi
B, et al: Integrative genomic analyses in adipocytes implicate DNA
methylation in human obesity and diabetes. Nat Commun. 14:27842023.
View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Yang Y, Chen Y, Xu S, Guo X, Jia G, Ping
J, Shu X, Zhao T, Yuan F, Wang G, et al: Integrating muti-omics
data to identify tissue-specific DNA methylation biomarkers for
cancer risk. Nat Commun. 15:60712024. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Eddy SR: Non-coding RNA genes and the
modern RNA world. Nat Rev Genet. 2:919–929. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Chauvier A and Walter NG: Regulation of
bacterial gene expression by non-coding RNA: It is all about time!
Cell Chem Biol. 31:71–85. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Fierro C, Gatti V, La Banca V, De Domenico
S, Scalera S, Corleone G, Fanciulli M, De Nicola F, Mauriello A,
Montanaro M, et al: The long non-coding RNA NEAT1 is a ΔNp63 target
gene modulating epidermal differentiation. Nat Commun. 14:37952023.
View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Soutschek M and Schratt G: Non-coding RNA
in the wiring and remodeling of neural circuits. Neuron.
111:2140–2154. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Qi Y, Ding L, Zhang S, Yao S, Ong J, Li Y,
Wu H and Du P: A plant immune protein enables broad antitumor
response by rescuing microRNA deficiency. Cell. 185:1888–1904.e24.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Nemeth K, Bayraktar R, Ferracin M and
Calin GA: Non-coding RNAs in disease: From mechanisms to
therapeutics. Nat Rev Genet. 25:211–232. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Inamura K: Major tumor suppressor and
oncogenic non-coding RNAs: Clinical relevance in lung cancer.
Cells. 6:122017. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Simon MD, Pinter SF, Fang R, Sarma K,
Rutenberg-Schoenberg M, Bowman SK, Kesner BA, Maier VK, Kingston RE
and Lee JT: High-resolution Xist binding maps reveal two-step
spreading during X-chromosome inactivation. Nature. 504:465–469.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Kwon Y and Chung YD: RNA-mediated
regulation of chromatin structures. Genes Genomics. 42:609–617.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou
Y, Huang J, Zhao X, Zhou J, Yan Y, et al: MicroRNA directly
enhances mitochondrial translation during muscle differentiation.
Cell. 158:607–619. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Fabian MR, Sonenberg N and Filipowicz W:
Regulation of mRNA translation and stability by microRNAs. Annu Rev
Biochem. 79:351–379. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Liu G, Kim J, Nguyen N, Zhou L and Dean A:
Long noncoding RNA GATA2AS influences human erythropoiesis by
transcription factor and chromatin landscape modulation. Blood.
143:2300–2313. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Shivdasani RA: MicroRNAs: Regulators of
gene expression and cell differentiation. Blood. 108:3646–3653.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Gregory RI and Shiekhattar R: MicroRNA
biogenesis and cancer. Cancer Res. 65:3509–3512. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Filipowicz W, Jaskiewicz L, Kolb FA and
Pillai RS: Post-transcriptional gene silencing by siRNAs and
miRNAs. Curr Opin Struct Biol. 15:331–341. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Zhou Y, Kong Y, Fan W, Tao T, Xiao Q, Li N
and Zhu X: Principles of RNA methylation and their implications for
biology and medicine. Biomed Pharmacother. 131:1107312020.
View Article : Google Scholar : PubMed/NCBI
|
|
120
|
He PC and He C: m6A RNA
methylation: from mechanisms to therapeutic potential. EMBO J.
40:e1059772021. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Yang Y, Hsu PJ, Chen YS and Yang YG:
Dynamic transcriptomic m6A decoration: writers, erasers,
readers and functions in RNA metabolism. Cell Res. 28:616–624.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Zhang W, Qian Y and Jia G: The detection
and functions of RNA modification m6A based on
m6A writers and erasers. J Biol Chem. 297:1009732021.
View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Wang MK, Gao CC and Yang YG: Emerging
roles of RNA methylation in development. Acc Chem Res.
56:3417–3427. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Sun T, Xu Y, Xiang Y, Ou J, Soderblom EJ
and Diao Y: Crosstalk between RNA m6A and DNA
methylation regulates transposable element chromatin activation and
cell fate in human pluripotent stem cells. Nat Genet. 55:1324–1335.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Wang L, Hui H, Agrawal K, Kang Y, Li N,
Tang R, Yuan J and Rana TM: m6A RNA methyltransferases
METTL3/14 regulate immune responses to anti-PD-1 therapy. EMBO J.
39:e1045142020. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Yang Y, Han W, Zhang A, Zhao M, Cong W,
Jia Y, Wang D and Zhao R: Chronic corticosterone disrupts the
circadian rhythm of CRH expression and m6A RNA methylation in the
chicken hypothalamus. J Anim Sci Biotechnol. 13:292022. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Zhao BS, Roundtree IA and He C:
Post-transcriptional gene regulation by mRNA modifications. Nat Rev
Mol Cell Biol. 18:31–42. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han
D, Fu Y, Parisien M, Dai Q, Jia G, et al:
N6-methyladenosine-dependent regulation of messenger RNA stability.
Nature. 505:117–120. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Li M, Ye J, Xia Y, Li M, Li G, Hu X, Su X,
Wang D, Zhao X, Lu F, et al: METTL3 mediates chemoresistance by
enhancing AML homing and engraftment via ITGA4. Leukemia.
36:2586–2595. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Keller L, Xu W, Wang HX, Winblad B,
Fratiglioni L and Graff C: The obesity related gene, FTO, interacts
with APOE, and is associated with Alzheimer's disease risk: A
prospective cohort study. J Alzheimers Dis. 23:461–469. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Wang X, Wu R, Liu Y, Zhao Y, Bi Z, Yao Y,
Liu Q, Shi H, Wang F and Wang Y: m6A mRNA methylation
controls autophagy and adipogenesis by targeting Atg5 and Atg7.
Autophagy. 16:1221–1235. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Li X, Ma S, Deng Y, Yi P and Yu J:
Targeting the RNA m6A modification for cancer
immunotherapy. Mol Cancer. 21:762022. View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Pullmann R, Kim HH, Abdelmohsen K, Lal A,
Martindale JL, Yang X and Gorospe M: Analysis of turnover and
translation regulatory RNA-binding protein expression through
binding to cognate mRNAs. Mol Cell Biol. 27:6265–6278. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Masuda K, Kuwano Y, Nishida K and Rokutan
K: General RBP expression in human tissues as a function of age.
Ageing Res Rev. 11:423–431. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Guo B, Dong R, Liang Y and Li M:
Haemostatic materials for wound healing applications. Nat Rev Chem.
5:773–791. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Brozovich FV, Nicholson CJ, Degen CV, Gao
YZ, Aggarwal M and Morgan KG: Mechanisms of vascular smooth muscle
contraction and the basis for pharmacologic treatment of smooth
muscle disorders. Pharmacol Rev. 68:476–532. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Ng F, Boucher S, Koh S, Sastry KSR, Chase
L, Lakshmipathy U, Choong C, Yang Z, Vemuri MC, Rao MS and Tanavde
V: PDGF, TGF-beta, and FGF signaling is important for
differentiation and growth of mesenchymal stem cells (MSCs):
Transcriptional profiling can identify markers and signaling
pathways important in differentiation of MSCs into adipogenic,
chondrogenic, and osteogenic lineages. Blood. 112:295–307. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
138
|
Swieringa F, Spronk HMH, Heemskerk JWM and
van der Meijden PEJ: Integrating platelet and coagulation
activation in fibrin clot formation. Res Pract Thromb Haemost.
2:450–460. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Sun J, Hua B, Livingston EW, Taves S,
Johansen PB, Hoffman M, Ezban M, Monroe DM, Bateman TA and Monahan
PE: Abnormal joint and bone wound healing in hemophilia mice is
improved by extending factor IX activity after hemarthrosis. Blood.
129:2161–2171. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Eming SA, Wynn TA and Martin P:
Inflammation and metabolism in tissue repair and regeneration.
Science. 356:1026–1030. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
141
|
de Oliveira S, Rosowski EE and
Huttenlocher A: Neutrophil migration in infection and wound repair:
Going forward in reverse. Nat Rev Immunol. 16:378–391. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Papayannopoulos V: Neutrophil
extracellular traps in immunity and disease. Nat Rev Immunol.
18:134–147. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Murray PJ and Wynn TA: Protective and
pathogenic functions of macrophage subsets. Nat Rev Immunol.
11:723–737. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Pober JS and Sessa WC: Inflammation and
the blood microvascular system. Cold Spring Harb Perspect Biol.
7:a0163452015. View Article : Google Scholar : PubMed/NCBI
|
|
145
|
Patel S, Srivastava S, Singh MR and Singh
D: Mechanistic insight into diabetic wounds: Pathogenesis,
molecular targets and treatment strategies to pace wound healing.
Biomed Pharmacother. 112:1086152019. View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Landén NX, Li D and Ståhle M: Transition
from inflammation to proliferation: A critical step during wound
healing. Cell Mol Life Sci. 73:3861–3885. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
147
|
Younesi FS, Miller AE, Barker TH, Rossi
FMV and Hinz B: Fibroblast and myofibroblast activation in normal
tissue repair and fibrosis. Nat Rev Mol Cell Biol. 25:617–638.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
148
|
Apte RS, Chen DS and Ferrara N: VEGF in
signaling and disease: Beyond discovery and development. Cell.
176:1248–1264. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
149
|
Rousselle P, Braye F and Dayan G:
Re-epithelialization of adult skin wounds: Cellular mechanisms and
therapeutic strategies. Adv Drug Deliv Rev. 146:344–365. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
150
|
Usui ML, Mansbridge JN, Carter WG, Fujita
M and Olerud JE: Keratinocyte migration, proliferation, and
differentiation in chronic ulcers from patients with diabetes and
normal wounds. J Histochem Cytochem. 56:687–696. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
151
|
Hattori N, Mochizuki S, Kishi K, Nakajima
T, Takaishi H, D'Armiento J and Okada Y: MMP-13 plays a role in
keratinocyte migration, angiogenesis, and contraction in mouse skin
wound healing. Am J Pathol. 175:533–546. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
152
|
Dasari N, Jiang A, Skochdopole A, Chung J,
Reece EM, Vorstenbosch J and Winocour S: Updates in diabetic wound
healing, inflammation, and scarring. Semin Plast Surg. 35:153–158.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
153
|
Singh D, Rai V and Agrawal DK: Regulation
of collagen I and collagen III in tissue injury and regeneration.
Cardiol Cardiovasc Med. 7:5–16. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
154
|
Mescher AL: Macrophages and fibroblasts
during inflammation and tissue repair in models of organ
regeneration. Regeneration (Oxf). 4:39–53. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
155
|
Mathew-Steiner SS, Roy S and Sen CK:
Collagen in wound healing. Bioengineering (Basel). 8:632021.
View Article : Google Scholar : PubMed/NCBI
|
|
156
|
Mishra T and Wairkar S: Pathogenesis,
attenuation, and treatment strategies for keloid management. Tissue
Cell. 94:1028002025. View Article : Google Scholar : PubMed/NCBI
|
|
157
|
Mann CJ, Perdiguero E, Kharraz Y, Aguilar
S, Pessina P, Serrano AL and Muñoz-Cánoves P: Aberrant repair and
fibrosis development in skeletal muscle. Skelet Muscle. 1:212011.
View Article : Google Scholar : PubMed/NCBI
|
|
158
|
Avishai E, Yeghiazaryan K and
Golubnitschaja O: Impaired wound healing: Facts and hypotheses for
multi-professional considerations in predictive, preventive and
personalised medicine. EPMA J. 8:23–33. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
159
|
Martin P, Pardo-Pastor C, Jenkins RG and
Rosenblatt J: Imperfect wound healing sets the stage for chronic
diseases. Science. 386:eadp2972024. View Article : Google Scholar
|
|
160
|
Jiang H, Guo Y, Wang Q, Wang Y, Peng D,
Fang Y, Yan L, Ruan Z, Zhang S, Zhao Y, et al: The dysfunction of
complement and coagulation in diseases: The implications for the
therapeutic interventions. MedComm (2020). 5:e7852024. View Article : Google Scholar : PubMed/NCBI
|
|
161
|
Tomaiuolo M, Brass LF and Stalker TJ:
Regulation of platelet activation and coagulation and its role in
vascular injury and arterial thrombosis. Interv Cardiol Clin.
6:1–12. 2017.PubMed/NCBI
|
|
162
|
Kapoor M and Appleton I: Wound healing:
Abnormalities and future therapeutic targets. Curr Anaesthesia Crit
Care. 16:88–93. 2005.
|
|
163
|
Sim X, Poncz M, Gadue P and French DL:
Understanding platelet generation from megakaryocytes: Implications
for in vitro-derived platelets. Blood. 127:1227–1233. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
164
|
Stankiewicz MJ and Crispino JD: ETS2 and
ERG promote megakaryopoiesis and synergize with alterations in
GATA-1 to immortalize hematopoietic progenitor cells. Blood.
113:3337–3347. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
165
|
Jackers P, Szalai G, Moussa O and Watson
DK: Ets-dependent regulation of target gene expression during
megakaryopoiesis. J Biol Chem. 279:52183–52190. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
166
|
Heuston EF, Keller CA, Lichtenberg J,
Giardine B, Anderson SM; NIH Intramural Sequencing Center, ;
Hardison RC and Bodine DM: Establishment of regulatory elements
during Erythro-megakaryopoiesis identifies hematopoietic
lineage-commitment points. Epigenetics Chromatin. 11:222018.
View Article : Google Scholar : PubMed/NCBI
|
|
167
|
Izzi B, Gianfagna F, Yang WY, Cludts K, De
Curtis A, Verhamme P, Di Castelnuovo A, Cerletti C, Donati MB, de
Gaetano G, et al: Variation of PEAR1 DNA methylation influences
platelet and leukocyte function. Clin Epigenetics. 11:1512019.
View Article : Google Scholar : PubMed/NCBI
|
|
168
|
Zhang R, Lu S, Yang X, Li M, Jia H, Liao
J, Jing Q, Wu Y, Wang H, Xiao F, et al: miR-19a-3p downregulates
tissue factor and functions as a potential therapeutic target for
sepsis-induced disseminated intravascular coagulation. Biochem
Pharmacol. 192:1146712021. View Article : Google Scholar : PubMed/NCBI
|
|
169
|
Shi P, Tan A, Ma Y, Que L, Li C, Shao Y,
Sun H, Li Y and Li J: miR-19a-3p enhances TGF-β1-induced cardiac
fibroblast activation via targeting BAMBI. J Biomed Res.
39:171–183. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
170
|
Cánovas-Cervera I, Nacher-Sendra E,
Osca-Verdegal R, Dolz-Andrés E, Beltrán-García J, Rodríguez-Gimillo
M, Ferrando-Sánchez C, Carbonell N and García-Giménez JL: The
intricate role of Non-coding RNAs in Sepsis-associated disseminated
intravascular coagulation. Int J Mol Sci. 24:25822023. View Article : Google Scholar : PubMed/NCBI
|
|
171
|
Wang G, Chai B and Yang L: MiR-128 and
miR-125 regulate expression of coagulation Factor IX gene with
nonsense mutation by repressing nonsense-mediated mRNA decay.
Biomed Pharmacother. 80:331–337. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
172
|
Eming SA, Krieg T and Davidson JM:
Inflammation in wound Repair: Molecular and cellular mechanisms. J
Invest Dermatol. 127:514–525. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
173
|
Enzerink A and Vaheri A: Fibroblast
activation in vascular inflammation. J Thromb Haemost. 9:619–626.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
174
|
Furman D, Campisi J, Verdin E,
Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW,
Fasano A, Miller GW, et al: Chronic inflammation in the etiology of
disease across the life span. Nat Med. 25:1822–1832. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
175
|
Das UN: Infection, inflammation, and
immunity in sepsis. Biomolecules. 13:13322023. View Article : Google Scholar : PubMed/NCBI
|
|
176
|
Antar SA, Ashour NA, Marawan ME and
Al-Karmalawy AA: Fibrosis: Types, effects, markers, mechanisms for
disease progression, and its relation with oxidative stress,
immunity, and inflammation. Int J Mol Sci. 24:40042023. View Article : Google Scholar : PubMed/NCBI
|
|
177
|
Audu CO, Melvin WJ, Joshi AD, Wolf SJ,
Moon JY, Davis FM, Barrett EC, Mangum KD, Deng H, Xing X, et al:
Macrophage-specific inhibition of the histone demethylase JMJD3
decreases STING and pathologic inflammation in diabetic wound
repair. Cell Mol Immunol. 19:1251–1262. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
178
|
Ariel A: JMJD3 regulates diabetic wound
repair in a STINGy fashion. Cell Mol Immunol. 20:110–111. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
179
|
Jiang Y, Xiang C, Zhong F, Zhang Y, Wang
L, Zhao Y, Wang J, Ding C, Jin L, He F and Wang H: Histone H3K27
methyltransferase EZH2 and demethylase JMJD3 regulate hepatic
stellate cells activation and liver fibrosis. Theranostics.
11:361–378. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
180
|
Zhang X, Liu L, Yuan X, Wei Y and Wei X:
JMJD3 in the regulation of human diseases. Protein Cell.
10:864–882. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
181
|
Nakka K, Hachmer S, Mokhtari Z, Kovac R,
Bandukwala H, Bernard C, Li Y, Xie G, Liu C, Fallahi M, et al:
JMJD3 activated hyaluronan synthesis drives muscle regeneration in
an inflammatory environment. Science. 377:666–669. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
182
|
Kimball AS, Davis FM, denDekker A, Joshi
AD, Schaller MA, Bermick J, Xing X, Burant CF, Obi AT, Nysz D, et
al: The histone methyltransferase Setdb2 modulates macrophage
phenotype and uric acid production in diabetic wound repair.
Immunity. 51:258–271.e5. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
183
|
Xu B, Musai J, Tan YS, Hile GA, Swindell
WR, Klein B, Qin JT, Sarkar MK, Gudjonsson JE and Kahlenberg JM: A
critical role for IFN-β signaling for IFN-κ induction in
keratinocytes. Front Lupus. 2:13597142024. View Article : Google Scholar : PubMed/NCBI
|
|
184
|
Wolf SJ, Audu CO, Joshi A, denDekker A,
Melvin WJ, Davis FM, Xing X, Wasikowski R, Tsoi LC, Kunkel SL, et
al: IFN-κ is critical for normal wound repair and is decreased in
diabetic wounds. JCI Insight. 7:e1527652022. View Article : Google Scholar : PubMed/NCBI
|
|
185
|
Dong Z, Li S, Huang Y, Chen T, Ding Y and
Tan Q: RNA N6-methyladenosine demethylase FTO promotes
diabetic wound healing through TRIB3-mediated autophagy in an
m6A-YTHDF2-dependent manner. Cell Death Dis. 16:2222025. View Article : Google Scholar : PubMed/NCBI
|
|
186
|
Liang D, Lin WJ, Ren M, Qiu J, Yang C,
Wang X, Li N, Zeng T, Sun K, You L, et al: m6A reader
YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Autophagy. 18:1318–1337. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
187
|
Dangwal S, Stratmann B, Bang C, Lorenzen
JM, Kumarswamy R, Fiedler J, Falk CS, Scholz CJ, Thum T and
Tschoepe D: Impairment of wound healing in patients with type 2
diabetes mellitus influences circulating MicroRNA patterns via
inflammatory cytokines. Arterioscler Thromb Vasc Biol.
35:1480–1488. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
188
|
Li D, Peng H, Qu L, Sommar P, Wang A, Chu
T, Li X, Bi X, Liu Q, Gallais Sérézal I, et al: miR-19a/b and
miR-20a Promote Wound Healing by Regulating the Inflammatory
Response of Keratinocytes. J Invest Dermatol. 141:659–671. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
189
|
Dawi J, Tumanyan K, Tomas K, Misakyan Y,
Gargaloyan A, Gonzalez E, Hammi M, Tomas S and Venketaraman V:
Diabetic foot ulcers: Pathophysiology, immune dysregulation, and
emerging therapeutic strategies. Biomedicines. 13:10762025.
View Article : Google Scholar : PubMed/NCBI
|
|
190
|
Omotosho IA, Shamsuddin N, Zaman Huri H,
Chong WL and Rehman IU: From control to cure: Insights into the
synergy of glycemic and antibiotic management in modulating the
severity and outcomes of diabetic foot ulcers. Int J Mol Sci.
26:69092025. View Article : Google Scholar : PubMed/NCBI
|
|
191
|
Hu K, Liu L, Tang S, Zhang X, Chang H,
Chen W, Fan T, Zhang L, Shen B and Zhang Q: MicroRNA-221-3p
inhibits the inflammatory response of keratinocytes by regulating
the DYRK1A/STAT3 signaling pathway to promote wound healing in
diabetes. Commun Biol. 7:3002024. View Article : Google Scholar : PubMed/NCBI
|
|
192
|
Hu J, Zhang L, Liechty C, Zgheib C, Hodges
MM, Liechty KW and Xu J: Long noncoding RNA GAS5 regulates
macrophage polarization and diabetic wound healing. J Invest
Dermatol. 140:1629–1638. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
193
|
Kaszycki J and Kim M: Epigenetic
regulation of transcription factors involved in NLRP3 inflammasome
and NF-kB signaling pathways. Front Immunol. 16:15297562025.
View Article : Google Scholar : PubMed/NCBI
|
|
194
|
Zhang S, Meng Y, Zhou L, Qiu L, Wang H, Su
D, Zhang B, Chan KM and Han J: Targeting epigenetic regulators for
inflammation: Mechanisms and intervention therapy. MedComm (2020).
3:e1732022. View Article : Google Scholar : PubMed/NCBI
|
|
195
|
Zhu X, Chen Z, Shen W, Huang G, Sedivy JM,
Wang H and Ju Z: Inflammation, epigenetics, and metabolism converge
to cell senescence and ageing: the regulation and intervention.
Signal Transduct Target Ther. 6:2452021. View Article : Google Scholar : PubMed/NCBI
|
|
196
|
Lee HW, Shin JH and Simons M: Flow goes
forward and cells step backward: Endothelial migration. Exp Mol
Med. 54:711–719. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
197
|
Piipponen M, Li D and Landén NX: The
immune functions of keratinocytes in skin wound healing. Int J Mol
Sci. 21:87902020. View Article : Google Scholar : PubMed/NCBI
|
|
198
|
Cialdai F, Risaliti C and Monici M: Role
of fibroblasts in wound healing and tissue remodeling on Earth and
in space. Front Bioeng Biotechnol. 10:9583812022. View Article : Google Scholar : PubMed/NCBI
|
|
199
|
Nguyễn-Thanh T, Kim D, Lee S, Kim W, Park
SK and Kang KP: Inhibition of histone deacetylase 1 ameliorates
renal tubulointerstitial fibrosis via modulation of inflammation
and extracellular matrix gene transcription in mice. Int J Mol Med.
41:95–106. 2018.PubMed/NCBI
|
|
200
|
Rutnam ZJ, Wight TN and Yang BB: miRNAs
regulate expression and function of extracellular matrix molecules.
Matrix Biol. 32:74–85. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
201
|
Li XJY, Zhou F, Li YJ, Xue XY, Qu JR, Fan
GF, Liu J, Sun R, Wu JZ, Zheng Q and Liu RP: LncRNA H19-EZH2
interaction promotes liver fibrosis via reprogramming H3K27me3
profiles. Acta Pharmacol Sin. 44:2479–2491. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
202
|
Adase CA, Borkowski AW, Zhang LJ, Williams
MR, Sato E, Sanford JA and Gallo RL: Non-coding Double-stranded RNA
and antimicrobial peptide LL-37 induce growth factor expression
from keratinocytes and endothelial cells. J Biol Chem.
291:11635–11646. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
203
|
Li X, Liu C, Zhu Y, Rao H, Liu M, Gui L,
Feng W, Tang H, Xu J, Gao WQ and Li L: SETD2 epidermal deficiency
promotes cutaneous wound healing via activation of AKT/mTOR
Signalling. Cell Prolif. 54:e130452021. View Article : Google Scholar : PubMed/NCBI
|
|
204
|
Jiang B, Tang Y, Wang H, Chen C, Yu W, Sun
H, Duan M, Lin X and Liang P: Down-regulation of long non-coding
RNA HOTAIR promotes angiogenesis via regulating miR-126/SCEL
pathways in burn wound healing. Cell Death Dis. 11:612020.
View Article : Google Scholar : PubMed/NCBI
|
|
205
|
Singh S, Young A and McNaught CE: The
physiology of wound healing. Surgery (Oxford). 35:473–477. 2017.
View Article : Google Scholar
|
|
206
|
Song R and Zhang L: Cardiac ECM: Its
epigenetic regulation and role in heart development and repair. Int
J Mol Sci. 21:86102020. View Article : Google Scholar : PubMed/NCBI
|
|
207
|
Gao Y, Zhang S, Zhang X, Du Y, Ni T and
Hao S: Crosstalk between metabolic and epigenetic modifications
during cell carcinogenesis. iScience. 27:1113592024. View Article : Google Scholar : PubMed/NCBI
|
|
208
|
Xue T, Qiu X, Liu H, Gan C, Tan Z, Xie Y,
Wang Y and Ye T: Epigenetic regulation in fibrosis progress.
Pharmacol Res. 173:1059102021. View Article : Google Scholar : PubMed/NCBI
|
|
209
|
Shiva Shankar TV and Willems L: Epigenetic
modulators mitigate angiogenesis through a complex transcriptomic
network. Vascul Pharmacol. 60:57–66. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
210
|
Ma Y, Liu Z, Miao L, Jiang X, Ruan H, Xuan
R and Xu S: Mechanisms underlying pathological scarring by
fibroblasts during wound healing. Int Wound J. 20:2190–2206. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
211
|
Liu Y, Li L, Wang JY, Gao F, Lin X, Lin
SS, Qiu ZY and Liang ZH: LncRNA GNAS-AS1 knockdown inhibits keloid
cells growth by mediating the miR-188-5p/RUNX2 axis. Mol Cell
Biochem. 478:707–719. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
212
|
Zou A, Liu P, Liu T and Li Q: Long
non-coding RNA HOXA11-AS contributes to the formation of keloid by
relieving the inhibition of miR-182-5p on ZNF217. Burns.
49:1157–1169. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
213
|
Kashiyama K, Mitsutake N, Matsuse M, Ogi
T, Saenko VA, Ujifuku K, Utani A, Hirano A and Yamashita S:
miR-196a downregulation increases the expression of type I and III
collagens in keloid fibroblasts. J Invest Dermatol. 132:1597–1604.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
214
|
Li Y, Wang W, Wang Y and Ai H:
FTO-mediated m6A demethylation of KLF4 promotes the
proliferation and collagen deposition of keloid fibroblasts.
Toxicol Res (Camb). 14:tfaf0582025. View Article : Google Scholar : PubMed/NCBI
|
|
215
|
Yang R, Wang X, Zheng W, Chen W, Gan W,
Qin X, Huang J, Chen X and Zhou S: Bioinformatics analysis and
verification of m6A related genes based on the construction of
keloid diagnostic model. Int Wound J. 20:2700–2717. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
216
|
Wilkinson HN and Hardman MJ: Wound
healing: Cellular mechanisms and pathological outcomes. Open Biol.
10:2002232020. View Article : Google Scholar : PubMed/NCBI
|
|
217
|
Rosenberg CS: Wound healing in the patient
with diabetes mellitus. Nurs Clin North Am. 25:247–261. 1990.
View Article : Google Scholar : PubMed/NCBI
|
|
218
|
Swoboda L and Held J: Impaired wound
healing in diabetes. J Wound Care. 31:882–885. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
219
|
Jaenisch R and Bird A: Epigenetic
regulation of gene expression: How the genome integrates intrinsic
and environmental signals. Nat Genet. 33 (Suppl):S245–S254. 2003.
View Article : Google Scholar
|
|
220
|
AlQahtani AD, O'Connor D, Domling A and
Goda SK: Strategies for the production of long-acting therapeutics
and efficient drug delivery for cancer treatment. Biomed
Pharmacother. 113:1087502019. View Article : Google Scholar : PubMed/NCBI
|
|
221
|
Fu Y, Timp W and Sedlazeck FJ:
Computational analysis of DNA methylation from long-read
sequencing. Nat Rev Genet. 26:620–634. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
222
|
Stephens KE, Miaskowski CA, Levine JD,
Pullinger CR and Aouizerat BE: Epigenetic regulation and
measurement of epigenetic changes. Biol Res Nurs. 15:373–381. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
223
|
Pajares MJ, Palanca-Ballester C, Urtasun
R, Alemany-Cosme E, Lahoz A and Sandoval J: Methods for analysis of
specific DNA methylation status. Methods. 187:3–12. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
224
|
Liu Z, Bian X, Luo L, Björklund ÅK, Li L,
Zhang L, Chen Y, Guo L, Gao J, Cao C, et al: Spatiotemporal
single-cell roadmap of human skin wound healing. Cell Stem Cell.
32:479–498.e8. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
225
|
McCutcheon SR, Rohm D, Iglesias N and
Gersbach CA: Epigenome editing technologies for discovery and
medicine. Nat Biotechnol. 42:1199–1217. 2024. View Article : Google Scholar : PubMed/NCBI
|
