|
1
|
Buie MJ, Quan J, Windsor JW, Coward S,
Hansen TM, King JA, Kotze PG, Gearry RB, Ng SC, Mak JWY, et al:
Global hospitalization trends for Crohn's disease and ulcerative
colitis in the 21st century: A systematic review with temporal
analyses. Clin Gastroenterol Hepatol. 21:2211–2221. 2023.
View Article : Google Scholar
|
|
2
|
Ordás I, Eckmann L, Talamini M, Baumgart
DC and Sandborn WJ: Ulcerative colitis. Lancet. 380:1606–1619.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Leppkes M and Neurath MF: Cytokines in
inflammatory bowel diseases - Update 2020. Pharmacol Res.
158:1048352020. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Le Berre C, Loeuille D and Peyrin-Biroulet
L: Combination therapy with vedolizumab and tofacitinib in a
patient with ulcerative colitis and spondyloarthropathy. Clin
Gastroenterol Hepatol. 17:794–796. 2019. View Article : Google Scholar
|
|
5
|
Abdalla MI and Levesque BG: Progress in
corticosteroid use in the Era of biologics with room for
improvement. Am J Gastroenterol. 116:1187–1188. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Quansah E, Gardey E, Ramoji A,
Meyer-Zedler T, Goehrig B, Heutelbeck A, Hoeppener S, Schmitt M,
Waldner M, Stallmach A and Popp J: Intestinal epithelial barrier
integrity investigated by label-free techniques in ulcerative
colitis patients. Sci Rep. 13:26812023. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Chen Q, Chen T, Xiao H, Wang F, Li C, Hu
N, Bao L, Tong X, Feng Y, Xu Y, et al: APEX1 in intestinal
epithelium triggers neutrophil infiltration and intestinal barrier
damage in ulcerative colitis. Free Radic Biol Med. 225:359–373.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Peterson LW and Artis D: Intestinal
epithelial cells: Regulators of barrier function and immune
homeostasis. Nat Rev Immunol. 14:141–153. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Jiminez JA, Uwiera TC, Douglas Inglis G
and Uwiera RR: Animal models to study acute and chronic intestinal
inflammation in mammals. Gut Pathog. 7:292015. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Yan H and Ajuwon KM: Butyrate modifies
intestinal barrier function in IPEC-J2 cells through a selective
upregulation of tight junction proteins and activation of the Akt
signaling pathway. PLoS One. 12:e01795862017. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Mehandru S and Colombel JF: The intestinal
barrier, an arbitrator turned provocateur in IBD. Nat Rev
Gastroenterol Hepatol. 18:83–84. 2021. View Article : Google Scholar
|
|
12
|
Su L, Nalle SC, Shen L, Turner ES, Singh
G, Breskin LA, Khramtsova EA, Khramtsova G, Tsai PY, Fu YX, et al:
TNFR2 activates MLCK-dependent tight junction dysregulation to
cause apoptosis-mediated barrier loss and experimental colitis.
Gastroenterology. 145:407–415. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Fukuda T, Majumder K, Zhang H, Turner PV,
Matsui T and Mine Y: Adenine inhibits TNF-α signaling in intestinal
epithelial cells and reduces mucosal inflammation in a dextran
sodium sulfate-induced colitis mouse model. J Agric Food Chem.
64:4227–4234. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Li W, Chen D, Zhu Y, Ye Q, Hua Y, Jiang P,
Xiang Y, Xu Y, Pan Y, Yang H, et al: Alleviating pyroptosis of
intestinal epithelial cells to restore mucosal integrity in
ulcerative colitis by targeting delivery of 4-Octyl-itaconate. ACS
Nano. 18:16658–16673. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Chi F, Zhang G, Ren N, Zhang J, Du F,
Zheng X, Zhang C, Lin Z, Li R, Shi X and Zhu Y: The anti-alcoholism
drug disulfiram effectively ameliorates ulcerative colitis through
suppressing oxidative stresses-associated pyroptotic cell death and
cellular inflammation in colonic cells. Int Immunopharmacol.
111:1091172022. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Chen Y, Yan W, Chen Y, Zhu J, Wang J, Jin
H, Wu H, Zhang G, Zhan S, Xi Q, et al: SLC6A14 facilitates
epithelial cell ferroptosis via the C/EBPβ-PAK6 axis in ulcerative
colitis. Cell Mol Life Sci. 79:5632022. View Article : Google Scholar
|
|
17
|
Zhang J, Cen L, Zhang X, Tang C, Chen Y,
Zhang Y, Yu M, Lu C, Li M, Li S, et al: MPST deficiency promotes
intestinal epithelial cell apoptosis and aggravates inflammatory
bowel disease via AKT. Redox Biol. 56:1024692022. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Foerster EG, Mukherjee T, Cabral-Fernandes
L, Rocha JDB, Girardin SE and Philpott DJ: How autophagy controls
the intestinal epithelial barrier. Autophagy. 18:86–103. 2022.
View Article : Google Scholar :
|
|
19
|
Xu M, Tao J, Yang Y, Tan S, Liu H, Jiang
J, Zheng F and Wu B: Ferroptosis involves in intestinal epithelial
cell death in ulcerative colitis. Cell Death Dis. 11:862020.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Ma ZR, Li ZL, Zhang N, Lu B, Li XW, Huang
YH, Nouhoum D, Liu XS, Xiao KC, Cai LT, et al: Inhibition of
GSDMD-mediated pyroptosis triggered by Trichinella spiralis
intervention contributes to the alleviation of DSS-induced
ulcerative colitis in mice. Parasit Vectors. 16:2802023. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Wang JM, Yang J, Xia WY, Wang YM, Zhu YB,
Huang Q, Feng T, Xie LS, Li SH, Liu SQ, et al: Comprehensive
analysis of PANoptosis-related gene signature of ulcerative
colitis. Int J Mol Sci. 25:3482023. View Article : Google Scholar
|
|
22
|
Akanyibah FA, Zhu Y, Jin T, Ocansey DKW,
Mao F and Qiu W: The function of necroptosis and its treatment
target in IBD. Mediators Inflamm. 2024:72753092024. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Iwanaga T and Takahashi-Iwanaga H:
Disposal of intestinal apoptotic epithelial cells and their fate
via divergent routes. Biomed Res. 43:59–72. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Soroosh A, Fang K, Hoffman JM, Law IKM,
Videlock E, Lokhandwala ZA, Zhao JJ, Hamidi S, Padua DM, Frey MR,
et al: Loss of miR-24-3p promotes epithelial cell apoptosis and
impairs the recovery from intestinal inflammation. Cell Death Dis.
13:82021. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Wolf P, Schoeniger A and Edlich F:
Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial
membrane. Biochim Biophys Acta Mol Cell Res. 1869:1193172022.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Sheridan C, Delivani P, Cullen SP and
Martin SJ: Bax- or Bak-induced mitochondrial fission can be
uncoupled from cytochrome C release. Mol Cell. 31:570–585. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Zhou M, Li Y, Hu Q, Bai XC, Huang W, Yan
C, Scheres SH and Shi Y: Atomic structure of the apoptosome:
mechanism of cytochrome c- and dATP-mediated activation of Apaf-1.
Genes Dev. 29:2349–2361. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Albalawi GA, Albalawi MZ, Alsubaie KT,
Albalawi AZ, Elewa MAF, Hashem KS and Al-Gayyar MMH: Curative
effects of crocin in ulcerative colitis via modulating apoptosis
and inflammation. Int Immunopharmacol. 118:1101382023. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Lin S, Zhang X, Zhu X, Jiao J, Wu Y, Li Y
and Zhao L: Fusobacterium nucleatum aggravates ulcerative colitis
through promoting gut microbiota dysbiosis and dysmetabolism. J
Periodontol. 94:405–418. 2023. View Article : Google Scholar
|
|
30
|
Li Y, Ma M, Wang X, Li J, Fang Z, Li J,
Yang B, Lu Y, Xu X and Li Y: Celecoxib alleviates the DSS-induced
ulcerative colitis in mice by enhancing intestinal barrier
function, inhibiting ferroptosis and suppressing apoptosis.
Immunopharmacol Immunotoxicol. 46:240–254. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Iwamoto M, Makiyama K, Koji T, Kohno S and
Nakane PK: Expression of Fas and Fas-ligand in epithelium of
ulcerative colitis. Nihon Rinsho. 54:1970–1974. 1996.In Japanese.
PubMed/NCBI
|
|
32
|
Souza HS, Tortori CJ, Castelo-Branco MT,
Carvalho AT, Margallo VS, Delgado CF, Dines I and Elia CC:
Apoptosis in the intestinal mucosa of patients with inflammatory
bowel disease: Evidence of altered expression of FasL and perforin
cytotoxic pathways. Int J Colorectal Dis. 20:277–286. 2005.
View Article : Google Scholar
|
|
33
|
Tang R, Jiang L, Ji Q, Kang P, Liu Y, Miao
P, Xu X and Tang M: Resveratrol targeting MDM2/P53/PUMA axis to
inhibit colonocyte apoptosis in DSS-induced ulcerative colitis
mice. Front Pharmacol. 16:15729062025. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Chen J: The Cell-Cycle Arrest and
Apoptotic Functions of p53 in Tumor Initiation and Progression.
Cold Spring Harb Perspect Med. 6:a0261042016. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Eissa N, Hussein H, Diarra A, Elgazzar O,
Gounni AS, Bernstein CN and Ghia JE: Semaphorin 3E regulates
apoptosis in the intestinal epithelium during the development of
colitis. Biochem Pharmacol. 166:264–273. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Parker A, Vaux L, Patterson AM, Modasia A,
Muraro D, Fletcher AG, Byrne HM, Maini PK, Watson AJM and Pin C:
Elevated apoptosis impairs epithelial cell turnover and shortens
villi in TNF-driven intestinal inflammation. Cell Death Dis.
10:1082019. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Yan R, Liang X and Hu J: MALAT1 promotes
colonic epithelial cell apoptosis and pyroptosis by sponging
miR-22-3p to enhance NLRP3 expression. PeerJ. 12:e184492024.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Yang L, Wu G, Wu Q, Peng L and Yuan L:
METTL3 overexpression aggravates LPS-induced cellular inflammation
in mouse intestinal epithelial cells and DSS-induced IBD in mice.
Cell Death Discov. 8:622022. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Wu MM, Wang QM, Huang BY, Mai CT, Wang CL,
Wang TT and Zhang XJ: Dioscin ameliorates murine ulcerative colitis
by regulating macrophage polarization. Pharmacol Res.
172:1057962021. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Palmela C, Chevarin C, Xu Z, Torres J,
Sevrin G, Hirten R, Barnich N, Ng SC and Colombel JF:
Adherent-invasive Escherichia coli in inflammatory bowel disease.
Gut. 67:574–587. 2018. View Article : Google Scholar
|
|
41
|
Chen B, Wang Y, Niu Y and Li S: Acalypha
australis L. Extract attenuates DSS-induced ulcerative colitis in
mice by regulating inflammatory factor release and blocking NF-κB
activation. J Med Food. 26:663–671. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Lasa JS, Olivera PA, Danese S and
Peyrin-Biroulet L: Efficacy and safety of biologics and small
molecule drugs for patients with moderate-to-severe ulcerative
colitis: A systematic review and network meta-analysis. Lancet
Gastroenterol Hepatol. 7:161–170. 2022. View Article : Google Scholar
|
|
43
|
Geng Z, Zuo L, Li J, Yin L, Yang J, Duan
T, Wang L, Zhang X, Song X, Wang Y and Hu J: Ginkgetin improved
experimental colitis by inhibiting intestinal epithelial cell
apoptosis through EGFR/PI3K/AKT signaling. FASEB J. 38:e238172024.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Lokman MS, Kassab RB, Salem FAM,
Elshopakey GE, Hussein A, Aldarmahi AA, Theyab A, Alzahrani KJ,
Hassan KE, Alsharif KF, et al: Asiatic acid rescues intestinal
tissue by suppressing molecular, biochemical, and histopathological
changes associated with the development of ulcerative colitis.
Biosci Rep. 44:BSR202320042024. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
He Z, Liu J and Liu Y: Daphnetin
attenuates intestinal inflammation, oxidative stress, and apoptosis
in ulcerative colitis via inhibiting REG3A-dependent JAK2/STAT3
signaling pathway. Environ Toxicol. 38:2132–2142. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Hu Q, Xie J, Jiang T, Gao P, Chen Y, Zhang
W, Yan J, Zeng J, Ma X and Zhao Y: Paeoniflorin alleviates
DSS-induced ulcerative colitis by suppressing inflammation,
oxidative stress, and apoptosis via regulating serum metabolites
and inhibiting CDC42/JNK signaling pathway. Int Immunopharmacol.
142(Pt A): 1130392024. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Gao F, Wu S, Zhang K, Xu Z, Zhang X, Zhu Z
and Quan F: Goat milk exosomes ameliorate ulcerative colitis in
mice through modulation of the intestinal barrier, gut microbiota,
and metabolites. J Agric Food Chem. 72:23196–23210. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Zhu F, Wei C, Wu H, Shuai B, Yu T, Gao F,
Yuan Y, Zuo D, Liu X, Zhang L and Fan H: Hypoxic mesenchymal stem
cell-derived exosomes alleviate ulcerative colitis injury by
limiting intestinal epithelial cells reactive oxygen species
accumulation and DNA damage through HIF-1α. Int Immunopharmacol.
113(Pt A): 1094262022. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Li H, Fan C, Lu H, Feng C, He P, Yang X,
Xiang C, Zuo J and Tang W: Protective role of berberine on
ulcerative colitis through modulating enteric glial
cells-intestinal epithelial cells-immune cells interactions. Acta
Pharm Sin B. 10:447–461. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Gao C, Liu L, Zhou Y, Bian Z, Wang S and
Wang Y: Novel drug delivery systems of Chinese medicine for the
treatment of inflammatory bowel disease. Chin Med. 14:232019.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Liu C, Gong Q, Liu W, Zhao Y, Yan X and
Yang T: Berberine-loaded PLGA nanoparticles alleviate ulcerative
colitis by targeting IL-6/IL-6R axis. J Transl Med. 22:9632024.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Buck A, Rezaei K, Quazi A, Goldmeier G,
Silverglate B and Grossberg GT: The donepezil transdermal system
for the treatment of patients with mild, moderate, or severe
Alzheimer's disease: A critical review. Expert Rev Neurother.
24:607–614. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Gwon HJ, Cho W, Choi SW, Lim DS,
Tanriverdi EÇ, Abd El-Aty AM, Jeong JH and Jung TW: Donepezil
improves skeletal muscle insulin resistance in obese mice via the
AMPK/FGF21-mediated suppression of inflammation and ferroptosis.
Arch Pharm Res. 47:940–953. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Li A, Zhang J, Chen K, Wang J, Xu A and
Wang Z: Donepezil attenuates inflammation and apoptosis in
ulcerative colitis via regulating LRP1/AMPK/NF-κB signaling. Pathol
Int. 73:549–559. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Li C, Xu Y, Gao T, Zhang S, Lin Z, Gu S,
Fang Y, Yuan X, Yu S, Jiang Q, et al: Ruxolitinib alleviates
inflammation, apoptosis, and intestinal barrier leakage in
ulcerative colitis via STAT3. Inflamm Bowel Dis. 29:1191–1201.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Tang R, Xu J, Zhang B, Liu J, Liang C, Hua
J, Meng Q, Yu X and Shi S: Ferroptosis, necroptosis, and pyroptosis
in anticancer immunity. J Hematol Oncol. 13:1102020. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Newton K: RIPK1 and RIPK3: Critical
regulators of inflammation and cell death. Trends Cell Biol.
25:347–353. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Degterev A, Ofengeim D and Yuan J:
Targeting RIPK1 for the treatment of human diseases. Proc Natl Acad
Sci USA. 116:9714–9722. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Zhang W, Zhu C, Liao Y, Zhou M, Xu W and
Zou Z: Caspase-8 in inflammatory diseases: A potential therapeutic
target. Cell Mol Biol Lett. 29:1302024. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Mifflin L, Ofengeim D and Yuan J:
Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic
target. Nat Rev Drug Discov. 19:553–571. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Zhou Y, Xiang Y, Liu S, Li C, Dong J, Kong
X, Ji X, Cheng X and Zhang L: RIPK3 signaling and its role in
regulated cell death and diseases. Cell Death Discov. 10:2002024.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Yuan J, Amin P and Ofengeim D: Necroptosis
and RIPK1-mediated neuroinflammation in CNS diseases. Nat Rev
Neurosci. 20:19–33. 2019. View Article : Google Scholar :
|
|
63
|
Karlowitz R and van Wijk SJL: Surviving
death: emerging concepts of RIPK3 and MLKL ubiquitination in the
regulation of necroptosis. FEBS J. 290:37–54. 2023. View Article : Google Scholar
|
|
64
|
Mohammed S, Thadathil N, Selvarani R,
Nicklas EH, Wang D, Miller BF, Richardson A and Deepa SS:
Necroptosis contributes to chronic inflammation and fibrosis in
aging liver. Aging Cell. 20:e135122021. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Jia Z, Xu C, Shen J, Xia T, Yang J and He
Y: The natural compound celastrol inhibits necroptosis and
alleviates ulcerative colitis in mice. Int Immunopharmacol.
29:552–559. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Lehle AS, Farin HF, Marquardt B, Michels
BE, Magg T, Li Y, Liu Y, Ghalandary M, Lammens K, Hollizeck S, et
al: Intestinal inflammation and dysregulated immunity in patients
with inherited caspase-8 deficiency. Gastroenterology. 156:275–278.
2019. View Article : Google Scholar
|
|
67
|
Pierdomenico M, Negroni A, Stronati L,
Vitali R, Prete E, Bertin J, Gough PJ, Aloi M and Cucchiara S:
Necroptosis is active in children with inflammatory bowel disease
and contributes to heighten intestinal inflammation. Am J
Gastroenterol. 109:279–287. 2014. View Article : Google Scholar
|
|
68
|
Liu L, Liang L, Yang C, Zhou Y and Chen Y:
Extracellular vesicles of Fusobacterium nucleatum compromise
intestinal barrier through targeting RIPK1-mediated cell death
pathway. Gut Microbes. 13:1–20. 2021. View Article : Google Scholar
|
|
69
|
Liu C, Wang H, Han L, Zhu Y, Ni S, Zhi J,
Yang X, Zhi J, Sheng T, Li H and Hu Q: Targeting P2Y(14)R protects
against necroptosis of intestinal epithelial cells through
PKA/CREB/RIPK1 axis in ulcerative colitis. Nat Commun. 15:20832024.
View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Dunker W, Ye X, Zhao Y, Liu L, Richardson
A and Karijolich J: TDP-43 prevents endogenous RNAs from triggering
a lethal RIG-I-dependent interferon response. Cell Rep.
35:1089762021. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Maelfait J, Liverpool L and Rehwinkel J:
Nucleic acid sensors and programmed cell death. J Mol Biol.
432:552–568. 2020. View Article : Google Scholar :
|
|
72
|
Li Y, Zou C, Chen C, Li S, Zhu Z, Fan Q,
Pang R, Li F, Chen Z, Wang Z, et al: Myeloid-derived MIF drives
RIPK1-mediated cerebromicrovascular endothelial cell death to
exacerbate ischemic brain injury. Proc Natl Acad Sci USA.
120:e22190911202023. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Soppert J, Kraemer S, Beckers C, Averdunk
L, Möllmann J, Denecke B, Goetzenich A, Marx G, Bernhagen J and
Stoppe C: Soluble CD74 reroutes MIF/CXCR4/AKT-mediated survival of
cardiac myofibroblasts to necroptosis. J Am Heart Assoc.
7:e0093842018. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Bao J, Ye B and Ren Y: ABIN1 inhibits
inflammation through necroptosis-dependent pathway in ulcerative
colitis. Genet Res (Camb). 2022:93135592022. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Duan C, Xu X, Lu X, Wang L and Lu Z: RIP3
knockdown inhibits necroptosis of human intestinal epithelial cells
via TLR4/MyD88/NF-κB signaling and ameliorates murine colitis. BMC
Gastroenterol. 22:1372022. View Article : Google Scholar
|
|
76
|
Zhong Y, Tu Y, Ma Q, Chen L, Zhang W, Lu
X, Yang S, Wang Z and Zhang L: Curcumin alleviates experimental
colitis in mice by suppressing necroptosis of intestinal epithelial
cells. Front Pharmacol. 14:11706372023. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Zhang J, Lei H, Hu X and Dong W:
Hesperetin ameliorates DSS-induced colitis by maintaining the
epithelial barrier via blocking RIPK3/MLKL necroptosis signaling.
Eur J Pharmacol. 873:1729922020. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Shen X, Chen H, Wen T, Liu L, Yang Y, Xie
F and Wang L: A natural chalcone cardamonin inhibits necroptosis
and ameliorates dextran sulfate sodium (DSS)-induced colitis by
targeting RIPK1/3 kinases. Eur J Pharmacol. 954:1758402023.
View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Li Z, Wang H, Wang Z and Geng Y: Pine
pollen polysaccharides' and sulfated polysaccharides' effects on UC
mice through modulation of cell tight junctions and RIPK3-dependent
necroptosis pathways. Molecules. 27:76822022. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Wang Y, Zhang B, Liu S, Xu E and Wang Z:
The traditional herb Sargentodoxa cuneata alleviates DSS-induced
colitis by attenuating epithelial barrier damage via blocking
necroptotic signaling. J Ethnopharmacol. 319(Pt 3): 1173732024.
View Article : Google Scholar
|
|
81
|
Zhou XL, Yang J, Qu XJ, Meng J, Miao RR
and Cui SX: M10, a Myricetin-3-O-b-D-lactose sodium salt, prevents
ulcerative colitis through inhibiting necroptosis in mice. Front
Pharmacol. 11:5573122020. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Peng C, Wu C, Xu X, Pan L, Lou Z, Zhao Y,
Jiang H, He Z and Ruan B: Indole-3-carbinol ameliorates necroptosis
and inflammation of intestinal epithelial cells in mice with
ulcerative colitis by activating aryl hydrocarbon receptor. Exp
Cell Res. 404:1126382021. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Zeng YS, Peng J, Gao XF, Tian D, Zhan W,
Liu J, Hu XJ, Huang S, Tian ST, Qiu L, et al: A novel
gut-restricted RIPK1 inhibitor, SZ-15, ameliorates DSS-induced
ulcerative colitis. Eur J Pharmacol. 937:1753812022. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Zhang C, He A, Liu S, He Q, Luo Y, He Z,
Chen Y, Tao A and Yan J: Inhibition of HtrA2 alleviated dextran
sulfate sodium (DSS)-induced colitis by preventing necroptosis of
intestinal epithelial cells. Cell Death Dis. 10:3442019. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Zhang C, Luo Y, He Q, Liu S, He A and Yan
J: A pan-RAF inhibitor LY3009120 inhibits necroptosis by preventing
phosphorylation of RIPK1 and alleviates dextran sulfate
sodium-induced colitis. Clin Sci (Lond). 133:919–932. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Kayagaki N, Webster JD and Newton K:
Control of cell death in health and disease. Annu Rev Pathol.
19:157–180. 2024. View Article : Google Scholar
|
|
87
|
Krzyzowska M, Shestakov A, Eriksson K and
Chiodi F: Role of Fas/FasL in regulation of inflammation in vaginal
tissue during HSV-2 infection. Cell Death Dis. 2:e1322011.
View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Ma D, Wang X, Liu J, Cui Y, Luo S and Wang
F: The development of necroptosis: What we can learn. Cell Stress
Chaperones. 28:969–987. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Nakano H, Murai S and Moriwaki K:
Regulation of the release of damage-associated molecular patterns
from necroptotic cells. Biochem J. 479:677–685. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Ma M, Jiang W and Zhou R: DAMPs and
DAMP-sensing receptors in inflammation and diseases. Immunity.
57:752–771. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Chen M, Rong R and Xia X: Spotlight on
pyroptosis: role in pathogenesis and therapeutic potential of
ocular diseases. J Neuroinflammation. 19:1832022. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Wei X, Xie F, Zhou X, Wu Y, Yan H, Liu T,
Huang J, Wang F, Zhou F and Zhang L: Role of pyroptosis in
inflammation and cancer. Cell Mol Immunol. 19:971–992. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Fu J and Wu H: Structural mechanisms of
NLRP3 inflammasome assembly and activation. Annu Rev Immunol.
41:301–316. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Biasizzo M and Kopitar-Jerala N: Interplay
Between NLRP3 Inflammasome and Autophagy. Front Immunol.
11:5918032020. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Que X, Zheng S, Song Q, Pei H and Zhang P:
Fantastic voyage: The journey of NLRP3 inflammasome activation.
Genes Dis. 11:819–829. 2024. View Article : Google Scholar
|
|
96
|
Nabavi-Rad A, Sadeghi A, Asadzadeh Aghdaei
H, Yadegar A, Smith SM and Zali MR: The double-edged sword of
probiotic supplementation on gut microbiota structure in
Helicobacter pylori management. Gut Microbes. 14:21086552022.
View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Wang Y, Yuan H, Shen D, Liu S, Kong W,
Zheng K, Yang J and Ge L: Artemisinin attenuated ischemic stroke
induced pyroptosis by inhibiting ROS/TXNIP/NLRP3/Caspase-1
signaling pathway. Biomed Pharmacother. 177:1168942024. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Zhang MY, Jiang YX, Yang YC, Liu JY, Huo
C, Ji XL and Qu YQ: Cigarette smoke extract induces pyroptosis in
human bronchial epithelial cells through the ROS/NLRP3/caspase-1
pathway. Life Sci. 269:1190902021. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Burdette BE, Esparza AN, Zhu H and Wang S:
Gasdermin D in pyroptosis. Acta Pharm Sin B. 11:2768–2782. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Yang Y, Li S, Liu K, Zhang Y, Zhu F, Ben
T, Chen Z and Zhi F: Lipocalin-2-mediated intestinal epithelial
cells pyroptosis via NF-κB/NLRP3/GSDMD signaling axis adversely
affects inflammation in colitis. Biochim Biophys Acta Mol Basis
Dis. 1870:1672792024. View Article : Google Scholar
|
|
101
|
Jena KK, Mambu J, Boehmer D, Sposito B,
Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenouil R,
Spinelli L, et al: Type III interferons induce pyroptosis in gut
epithelial cells and impair mucosal repair. Cell.
187:7533–7550.e23. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Liu X, Zhou M, Dai Z, Luo S, Shi Y, He Z
and Chen Y: Salidroside alleviates ulcerative colitis via
inhibiting macrophage pyroptosis and repairing the
dysbacteriosis-associated Th17/Treg imbalance. Phytother Res.
37:367–382. 2023. View Article : Google Scholar
|
|
103
|
Zhang S, Zhong R, Tang S, Chen L and Zhang
H: Metabolic regulation of the Th17/Treg balance in inflammatory
bowel disease. Pharmacol Res. 203:1071842024. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Zhang D, Ge F, Ji J, Li YJ, Zhang FR, Wang
SY, Zhang SJ, Zhang DM and Chen M: β-sitosterol alleviates dextran
sulfate sodium-induced experimental colitis via inhibition of
NLRP3/Caspase-1/GSDMD-mediated pyroptosis. Front Pharmacol.
14:12184772023. View Article : Google Scholar
|
|
105
|
Shen J, Zhao Y and Cui W: Astragalus
mongholicus Bunge extract improves ulcerative colitis by promoting
PLCB2 to inhibit colonic epithelial cell pyroptosis. J
Ethnopharmacol. 334:1185542024. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Shao M, Yan Y, Zhu F, Yang X, Qi Q, Yang
F, Hao T, Lin Z, He P, Zhou Y, et al: Artemisinin analog SM934
alleviates epithelial barrier dysfunction via inhibiting apoptosis
and caspase-1-mediated pyroptosis in experimental colitis. Front
Pharmacol. 13:8490142022. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Zhang W, Wang W, Shen C, Wang X, Pu Z and
Yin Q: Network pharmacology for systematic understanding of
Schisandrin B reduces the epithelial cells injury of colitis
through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome.
Aging (Albany NY). 13:23193–23209. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Zhao P, Ning J, Huang J and Huang X:
Mechanism of resveratrol on LPS/ATP-induced pyroptosis and
inflammatory response in HT29 cells. Autoimmunity. 57:24270942024.
View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Chang Y, Zhang Y, Jiang Y, Zhao L, Lv C,
Huang Q, Guan J and Jin S: From hair to colon: Hair
follicle-derived MSCs alleviate pyroptosis in DSS-Induced
ulcerative colitis by releasing exosomes in a paracrine manner.
Oxid Med Cell Longev. 2022:90975302022. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Wang D, Xue H, Tan J, Liu P, Qiao C, Pang
C and Zhang L: Bone marrow mesenchymal stem cells-derived exosomes
containing miR-539-5p inhibit pyroptosis through NLRP3/caspase-1
signalling to alleviate inflammatory bowel disease. Inflamm Res.
71:833–846. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Yan R, Liang X and Hu J: miR-141-3p
alleviates ulcerative colitis by targeting SUGT1 to inhibit colonic
epithelial cell pyroptosis. Autoimmunity. 56:22209882023.
View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Oraby MA, Abdel Mageed SS, Amr Raouf A,
Abdelshafy DA, Ahmed EF, Khalil RT, Mangoura SA and Fadaly DS:
Remdesivir ameliorates ulcerative colitis-propelled cell
inflammation and pyroptosis in acetic acid rats by restoring
SIRT6/FoxC1 pathway. Int Immunopharmacol. 137:1124652024.
View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Li J, Wu H, Zhou J, Jiang R, Zhuo Z, Yang
Q, Chen H and Sha W: Ruscogenin attenuates ulcerative colitis in
mice by inhibiting caspase-1-dependent pyroptosis via the
TLR4/NF-κB signaling pathway. Biomedicines. 12:9892024. View Article : Google Scholar
|
|
114
|
Chen L, Liu D, Mao M, Liu W, Wang Y, Liang
Y, Cao W and Zhong X: Betaine ameliorates acute sever ulcerative
colitis by inhibiting oxidative stress induced inflammatory
pyroptosis. Mol Nutr Food Res. 66:e22003412022. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta
R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS,
et al: Ferroptosis: An iron-dependent form of nonapoptotic cell
death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Mou Y, Wang J, Wu J, He D, Zhang C, Duan C
and Li B: Ferroptosis, a new form of cell death: Opportunities and
challenges in cancer. J Hematol Oncol. 12:342019. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Chen AC, Donovan A, Ned-Sykes R and
Andrews NC: Noncanonical role of transferrin receptor 1 is
essential for intestinal homeostasis. Proc Natl Acad Sci USA.
112:11714–11719. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Lomphithak T, Sae-Fung A, Sprio S,
Tampieri A, Jitkaew S and Fadeel B: Exploiting the ferroaddiction
of pancreatic cancer cells using Fe-doped nanoparticles.
Nanomedicine. 55:1027142024. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Cai H, Chen S, Zhu Y, Zhuang S, Wang J,
Niu X, Cui T, Huang H, Ao R, Yu M, et al: A pH/STEAP
cascade-responsive nanomedicine with self-supplied peroxide for
precise chemodynamic therapy. Adv Healthc Mater. 14:e25007522025.
View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Yang WS, Kim KJ, Gaschler MM, Patel M,
Shchepinov MS and Stockwell BR: Peroxidation of polyunsaturated
fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci
USA. 113:E4966–E4975. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Yang WS, SriRamaratnam R, Welsch ME,
Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji
AF, Clish CB, et al: Regulation of ferroptotic cancer cell death by
GPX4. Cell. 156:317–331. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Sun SP, Lu YF, Li H, Weng CY, Chen JJ, Lou
YJ, Lyu D and Lyu B: AMPK activation alleviated dextran sulfate
sodium-induced colitis by inhibiting ferroptosis. J Dig Dis.
24:213–223. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Guo M, Du X and Wang X: Inhibition of
ferroptosis: A new direction in the treatment of ulcerative colitis
by traditional Chinese medicine. J Ethnopharmacol. 324:1177872024.
View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Huang F, Zhang S, Li X, Huang Y, He S and
Luo L: STAT3-mediated ferroptosis is involved in ulcerative
colitis. Free Radic Biol Med. 188:375–385. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Chen Y, Zhang P, Chen W and Chen G:
Ferroptosis mediated DSS-induced ulcerative colitis associated with
Nrf2/HO-1 signaling pathway. Immunol Lett. 225:9–15. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Zhu J, Wu Y, Ge X, Chen X and Mei Q:
Discovery and validation of ferroptosis-associated genes of
ulcerative colitis. J Inflamm Res. 17:4467–4482. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Yokote A, Imazu N, Umeno J, Kawasaki K,
Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K,
et al: Ferroptosis in the colon epithelial cells as a therapeutic
target for ulcerative colitis. J Gastroenterol. 58:868–882. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Lam IH, Chan CI, Han M, Li L and Yu HH:
ACSL4 mediates inflammatory bowel disease and contributes to
LPS-induced intestinal epithelial cell dysfunction by activating
ferroptosis and inflammation. Open Med (Wars). 19:202409932024.
View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Chen Y, Wang J, Li J, Zhu J, Wang R, Xi Q,
Wu H, Shi T and Chen W: Astragalus polysaccharide prevents
ferroptosis in a murine model of experimental colitis and human
Caco-2 cells via inhibiting NRF2/HO-1 pathway. Eur J Pharmacol.
911:1745182021. View Article : Google Scholar
|
|
130
|
Ni J, Zhang L, Feng G, Bao W, Wang Y,
Huang Y, Chen T, Chen J, Cao X, You K, et al: Vanillic acid
restores homeostasis of intestinal epithelium in colitis through
inhibiting CA9/STIM1-mediated ferroptosis. Pharmacol Res.
202:1071282024. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Long D, Mao C, Huang Y, Xu Y and Zhu Y:
Ferroptosis in ulcerative colitis: Potential mechanisms and
promising therapeutic targets. Biomed Pharmacother. 175:1167222024.
View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Wu X, Zhao L, Yu Z and Zhang K:
Buddlejasaponin IVb Alleviates DSS-Induced ulcerative colitis
through the Nrf2/GPX4 pathway and gut microbiota modulation. J
Agric Food Chem. 72:23183–23195. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Ji W, Zhang Y, Qian X, Hu C and Huo Y:
Palmatine alleviates inflammation and modulates ferroptosis against
dextran sulfate sodium (DSS)-induced ulcerative colitis. Int
Immunopharmacol. 143(Pt 2): 1133962024. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Wu Y, Ran L, Yang Y, Gao X, Peng M, Liu S,
Sun L, Wan J, Wang Y, Yang K, et al: Deferasirox alleviates
DSS-induced ulcerative colitis in mice by inhibiting ferroptosis
and improving intestinal microbiota. Life Sci. 314:1213122023.
View Article : Google Scholar
|
|
135
|
Porter JB: A risk-benefit assessment of
iron-chelation therapy. Drug Saf. 17:407–421. 1997. View Article : Google Scholar
|
|
136
|
Di Paola A, Tortora C, Argenziano M,
Marrapodi MM and Rossi F: Emerging roles of the iron chelators in
inflammation. Int J Mol Sci. 23:79772022. View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Chen H, Qian Y, Jiang C, Tang L, Yu J,
Zhang L, Dai Y and Jiang G: Butyrate ameliorated ferroptosis in
ulcerative colitis through modulating Nrf2/GPX4 signal pathway and
improving intestinal barrier. Biochim Biophys Acta Mol Basis Dis.
1870:1669842024. View Article : Google Scholar
|
|
138
|
Gao S, Sun C and Kong J: Vitamin D
attenuates ulcerative colitis by inhibiting ACSL4-mediated
ferroptosis. Nutrients. 15:48452023. View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Shi J, Ji S, Xu M, Wang Y and Shi H:
Selenium inhibits ferroptosis in ulcerative colitis through the
induction of Nrf2/Gpx4. Clin Res Hepatol Gastroenterol.
48:1024672024. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Gao BB, Wang L, Li LZ, Fei ZQ, Wang YY,
Zou XM, Huang MC, Lei SS and Li B: Beneficial effects of oxymatrine
from Sophora flavescens on alleviating Ulcerative colitis by
improving inflammation and ferroptosis. J Ethnopharmacol.
332:1183852024. View Article : Google Scholar : PubMed/NCBI
|
|
141
|
Li W, Wang Y, Zhang Y, Fan Y, Liu J, Zhu
K, Jiang S and Duan J: Lizhong decoction ameliorates ulcerative
colitis by inhibiting ferroptosis of enterocytes via the
Nrf2/SLC7A11/GPX4 pathway. J Ethnopharmacol. 326:1179662024.
View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Wei Z, Hang S, Wiredu Ocansey DK, Zhang Z,
Wang B, Zhang X and Mao F: Human umbilical cord mesenchymal stem
cells derived exosome shuttling mir-129-5p attenuates inflammatory
bowel disease by inhibiting ferroptosis. J Nanobiotechnology.
21:1882023. View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Zhu Y, Qin H, Sun C, Shao B, Li G, Qin Y,
Kong D, Ren S, Wang H, Wang Z, et al: Endometrial regenerative
cell-derived exosomes attenuate experimental colitis through
downregulation of intestine ferroptosis. Stem Cells Int.
2022:30141232022. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Takabatake Y, Kimura T, Takahashi A and
Isaka Y: Autophagy and the kidney: health and disease. Nephrol Dial
Transplant. 29:1639–1647. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
145
|
Anding AL and Baehrecke EH: Autophagy in
cell life and cell death. Curr Top Dev Biol. 114:67–91. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Mizushima N and Komatsu M: Autophagy:
renovation of cells and tissues. Cell. 147:728–741. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
147
|
Klionsky DJ, Cregg JM, Dunn WA Jr, Emr SD,
Sakai Y, Sandoval IV, Sibirny A, Subramani S, Thumm M, Veenhuis M
and Ohsumi Y: A unified nomenclature for yeast autophagy-related
genes. Dev Cell. 5:539–545. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
148
|
Mizushima N: A brief history of autophagy
from cell biology to physiology and disease. Nat Cell Biol.
20:521–527. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
149
|
Yu L, Chen Y and Tooze SA: Autophagy
pathway: Cellular and molecular mechanisms. Autophagy. 14:207–215.
2018. View Article : Google Scholar :
|
|
150
|
Shen HM and Mizushima N: At the end of the
autophagic road: An emerging understanding of lysosomal functions
in autophagy. Trends Biochem Sci. 39:61–71. 2014. View Article : Google Scholar
|
|
151
|
Takeshige K, Baba M, Tsuboi S, Noda T and
Ohsumi Y: Autophagy in yeast demonstrated with proteinase-deficient
mutants and conditions for its induction. J Cell Biol. 119:301–311.
1992. View Article : Google Scholar : PubMed/NCBI
|
|
152
|
Liu Z and Wang H: Probiotics alleviate
inflammatory bowel disease in mice by regulating intestinal
microorganisms-bile acid-NLRP3 inflammasome pathway. Acta Biochim
Pol. 68:687–693. 2021.PubMed/NCBI
|
|
153
|
Zhang C, Yan J, Xiao Y, Shen Y, Wang J, Ge
W and Chen Y: Inhibition of autophagic degradation process
contributes to claudin-2 expression increase and epithelial tight
junction dysfunction in TNF-α treated cell monolayers. Int J Mol
Sci. 18:572017.
|
|
154
|
Hu X, Deng J, Yu T, Chen S, Ge Y, Zhou Z,
Guo Y, Ying H, Zhai Q, Chen Y, et al: ATF4 deficiency promotes
intestinal inflammation in mice by reducing uptake of glutamine and
expression of antimicrobial peptides. Gastroenterology.
156:1098–1111. 2019. View Article : Google Scholar
|
|
155
|
Chen Z, Gu Q and Chen R: miR-146a-5p
regulates autophagy and NLRP3 inflammasome activation in epithelial
barrier damage in the in vitro cell model of ulcerative colitis
through the RNF8/Notch1/mTORC1 pathway. Immunobiology.
228:1523862023. View Article : Google Scholar : PubMed/NCBI
|
|
156
|
Zhou M, Xu W, Wang J, Yan J, Shi Y, Zhang
C, Ge W, Wu J, Du P and Chen Y: Boosting mTOR-dependent autophagy
via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB
pathway quenches intestinal inflammation and oxidative stress
injury. EBioMedicine. 35:345–360. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
157
|
Martinon F, Burns K and Tschopp J: The
inflammasome: a molecular platform triggering activation of
inflammatory caspases and processing of proIL-beta. Mol Cell.
10:417–426. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
158
|
Takahama M, Akira S and Saitoh T:
Autophagy limits activation of the inflammasomes. Immunol Rev.
281:62–73. 2018. View Article : Google Scholar
|
|
159
|
Shen T, Li S, Cai LD, Liu JL, Wang CY, Gan
WJ, Li XM, Wang JR, Sun LN, Deng M, et al: Erbin exerts a
protective effect against inflammatory bowel disease by suppressing
autophagic cell death. Oncotarget. 9:12035–12049. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
160
|
Pan SM, Wang CL, Hu ZF, Zhang ML, Pan ZF,
Zhou RY, Wang XJ, Huang SW, Li YY, Wang Q, et al: Baitouweng
decoction repairs the intestinal barrier in DSS-induced colitis
mice via regulation of AMPK/mTOR-mediated autophagy. J
Ethnopharmacol. 318(Pt A): 1168882024. View Article : Google Scholar
|
|
161
|
Zhang H, Lang W, Liu X, Bai J, Jia Q and
Shi Q: Procyanidin A1 alleviates DSS-induced ulcerative colitis via
regulating AMPK/mTOR/p70S6K-mediated autophagy. J Physiol Biochem.
78:213–227. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
162
|
Watanabe-Yasuoka Y, Gotou A, Shimizu S and
Sashihara T: Lactiplantibacillus plantarum OLL2712 Induces
Autophagy via MYD88 and strengthens tight junction integrity to
promote the barrier function in intestinal epithelial cells.
Nutrients. 15:26552023. View Article : Google Scholar : PubMed/NCBI
|
|
163
|
Liu Y, Deng S, Sun L, He H, Zhou Q, Fan H,
Yang C and Yang J: Compound sophorae decoction mitigates
DSS-induced ulcerative colitis by activating autophagy through
PI3K-AKT pathway: A integrative research combining network
pharmacology and in vivo animal model validation. J Ethnopharmacol.
337:1188852025. View Article : Google Scholar
|
|
164
|
Qiao D, Liu X, Zhang Y, Zhang Z, Tang Y,
Chen Q, Shi Y, Chen Y, Tang Z and Dai Y: Jianpi-Qingchang decoction
alleviates ulcerative colitis by modulating endoplasmic reticulum
stress-related autophagy in intestinal epithelial cells. Biomed
Pharmacother. 158:1141332023. View Article : Google Scholar
|
|
165
|
Zhao L, Jiang T, Zhang Y and Shen Z:
Epimedium polysaccharides ameliorate ulcerative colitis by
inhibiting oxidative stress and regulating autophagy. J Sci Food
Agric. 105:2655–2670. 2025. View Article : Google Scholar
|
|
166
|
Xu Y, Tian Y, Li F, Wang Y, Yang J, Gong
H, Wan X and Ouyang M: Circular RNA HECTD1 mitigates ulcerative
colitis by promoting enterocyte autophagy Via miR-182-5p/HuR axis.
Inflamm Bowel Dis. 28:273–288. 2022. View Article : Google Scholar
|
|
167
|
Chen B, Carr L and Dun XP: Dynamic
expression of Slit1-3 and Robo1-2 in the mouse peripheral nervous
system after injury. Neural Regen Res. 15:948–958. 2020. View Article : Google Scholar
|
|
168
|
Wang L, Zheng J, Pathak JL, Chen Y, Liang
D, Yang L, Sun H, Zhong M, Wu L, Li L, et al: SLIT2 overexpression
in periodontitis intensifies inflammation and alveolar bone loss,
possibly via the activation of MAPK pathway. Front Cell Dev Biol.
8:5932020. View Article : Google Scholar : PubMed/NCBI
|
|
169
|
Xie J, Li L, Deng S, Chen J, Gu Q, Su H,
Wen L, Wang S, Lin C, Qi C, et al: Slit2/Robo1 mitigates
dss-induced ulcerative colitis by activating autophagy in
intestinal stem cell. Int J Biol Sci. 16:1876–1887. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
170
|
Wei S, Zhang J, Wu X, Chen M, Huang H,
Zeng S, Xiang Z, Li X and Dong W: Fusobacterium nucleatum
Extracellular Vesicles Promote Experimental Colitis by Modulating
Autophagy via the miR-574-5p/CARD3 Axis. Inflamm Bowel Dis.
29:9–26. 2023. View Article : Google Scholar
|
|
171
|
Wang XJ, Zhang D, Yang YT, Li XY, Li HN,
Zhang XP, Long JY, Lu YQ, Liu L, Yang G, et al: Suppression of
microRNA-222-3p ameliorates ulcerative colitis and
colitis-associated colorectal cancer to protect against oxidative
stress via targeting BRG1 to activate Nrf2/HO-1 signaling pathway.
Front Immunol. 14:10898092023. View Article : Google Scholar : PubMed/NCBI
|
|
172
|
Liang H, Zhang F, Wang W, Zhao W, Zhou J,
Feng Y, Wu J, Li M, Bai X, Zeng Z, et al: Heat shock transcription
factor 2 promotes mitophagy of intestinal epithelial cells through
PARL/PINK1/Parkin pathway in ulcerative colitis. Front Pharmacol.
13:8934262022. View Article : Google Scholar : PubMed/NCBI
|
|
173
|
Zhu P, Ke ZR, Chen JX, Li SJ, Ma TL and
Fan XL: Advances in mechanism and regulation of PANoptosis:
Prospects in disease treatment. Front Immunol. 14:11200342023.
View Article : Google Scholar : PubMed/NCBI
|
|
174
|
Qi Z, Zhu L, Wang K and Wang N:
PANoptosis: Emerging mechanisms and disease implications. Life Sci.
333:1221582023. View Article : Google Scholar : PubMed/NCBI
|
|
175
|
Sun X, Yang Y, Meng X, Li J, Liu X and Liu
H: PANoptosis: Mechanisms, biology, and role in disease. Immunol
Rev. 321:246–262. 2024. View Article : Google Scholar
|
|
176
|
You YP, Yan L, Ke HY, Li YP, Shi ZJ, Zhou
ZY, Yang HY, Yuan T, Gan YQ, Lu N, et al: Baicalin inhibits
PANoptosis by blocking mitochondrial Z-DNA formation and
ZBP1-PANoptosome assembly in macrophages. Acta Pharmacol Sin.
46:430–447. 2025. View Article : Google Scholar
|
|
177
|
Shi C, Cao P, Wang Y, Zhang Q, Zhang D,
Wang Y, Wang L and Gong Z: PANoptosis: A cell death characterized
by pyroptosis, apoptosis, and necroptosis. J Inflamm Res.
16:1523–1532. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
178
|
Malireddi RKS, Kesavardhana S, Karki R,
Kancharana B, Burton AR and Kanneganti TD: RIPK1 distinctly
regulates yersinia-induced inflammatory cell death, PANoptosis.
Immunohorizons. 4:789–796. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
179
|
Newton K, Wickliffe KE, Dugger DL,
Maltzman A, Roose-Girma M, Dohse M, Kőműves L, Webster JD and Dixit
VM: Cleavage of RIPK1 by caspase-8 is crucial for limiting
apoptosis and necroptosis. Nature. 574:428–431. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
180
|
Zheng Z, Deng W, Bai Y, Miao R, Mei S,
Zhang Z, Pan Y, Wang Y, Min R, Deng F, et al: The lysosomal
rag-ragulator complex licenses RIPK1 and caspase-8-mediated
pyroptosis by yersinia. Science. 372:eabg02692021. View Article : Google Scholar
|
|
181
|
Van Opdenbosch N, Van Gorp H, Verdonckt M,
Saavedra PHV, de Vasconcelos NM, Gonçalves A, Vande Walle L, Demon
D, Matusiak M, Van Hauwermeiren F, et al: Caspase-1 engagement and
TLR-Induced c-FLIP expression suppress ASC/Caspase-8-Dependent
apoptosis by inflammasome sensors NLRP1b and NLRC4. Cell Rep.
21:3427–3444. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
182
|
Gutierrez KD, Davis MA, Daniels BP, Olsen
TM, Ralli-Jain P, Tait SW, Gale M Jr and Oberst A: MLKL activation
triggers NLRP3-mediated processing and release of IL-1β
independently of gasdermin-D. J Immunol. 198:2156–2164. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
183
|
Ye Z, Deng M, Yang Y, Song Y, Weng L, Qi
W, Ding P, Huang Y, Yu C, Wang Y, et al: Epithelial mitochondrial
fission-mediated PANoptosis is crucial for ulcerative colitis and
its inhibition by saquinavir through Drp1. Pharmacol Res.
210:1075382024. View Article : Google Scholar : PubMed/NCBI
|
