[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Chen,Yiyuan; Li,Zhenye; Fang,Qiuyue; Wang,Hongyun; Li,Chuzhong; Gao,Hua; Zhang,Yazhuo

doi:10.3892/ijmm.2025.5680

January-2026 Volume 57 Issue 1

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January-2026 Volume 57 Issue 1

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Expression of Concern Open Access

[Expression of Concern] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Authors:
- Yiyuan Chen
- Zhenye Li
- Qiuyue Fang
- Hongyun Wang
- Chuzhong Li
- Hua Gao
- Yazhuo Zhang
View Affiliations / Copyright

Affiliations: Department of Cell Biology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, P.R. China, Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100070, P.R. China

Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 9
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Published online on: October 29, 2025

https://doi.org/10.3892/ijmm.2025.5680
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Abstract

Following the publication of the above paper, it was drawn to the Editor's attention by an interested reader that, regarding the western blot data shown in Fig. 5 on p. 507, the first set of GAPDH bands for the GH3 cell line were strikingly similar to the EGFR protein bands shown for the GT1‑1 cell line in the adjacent set of gels, such that the same data had apparently been used to represent the two different proteins.
The authors were contacted by the Editorial Office to offer an explanation for the apparent duplication of data in this paper, although up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further. [International Journal of Molecular Medicine 47: 500‑510, 2011; DOI: 10.3892/ijmm.2020.4807]

Int J Mol Med 47: [Related article:] 500-510, 2011; DOI: 10.3892/ijmm.2020.4807

The authors were contacted by the Editorial Office to offer an explanation for the apparent duplication of data in this paper, although up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Expression of Concern] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

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Abstract

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