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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.
International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.
Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.
Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.
Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.
International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.
Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.
Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.
Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.
An International Open Access Journal Devoted to General Medicine.
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Magalhães JE and Sampaio Rocha-Filho PA: Migraine and cerebrovascular diseases: Epidemiology, pathophysiological, and clinical considerations. Headache. 58:1277–1286. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zanon Zotin MC, Sveikata L, Viswanathan A and Yilmaz P: Cerebral small vessel disease and vascular cognitive impairment: From diagnosis to management. Curr Opin Neurol. 34:246–257. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Gottesman RF and Seshadri S: Risk factors, lifestyle behaviors, and vascular brain health. Stroke. 53:394–403. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Nordestgaard LT, Christoffersen M and Frikke-Schmidt R: Shared risk factors between dementia and atherosclerotic cardiovascular disease. Int J Mol Sci. 23:97772022. View Article : Google Scholar : PubMed/NCBI | |
|
Tsao CW, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Beaton AZ, Boehme AK, Buxton AE, et al: Heart disease and stroke statistics-2023 update: A report from the American heart association. Circulation. 147:e93–e621. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Hilkens NA, Casolla B, Leung TW and de Leeuw FE: Stroke. Lancet. 403:2820–2836. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Goldsborough E III, Osuji N and Blaha MJ: Assessment of cardiovascular disease risk: A 2022 update. Endocrinol Metab Clin North Am. 51:483–509. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Z, Ma L, Liu M, Fan J and Hu S: Summary of the 2022 report on cardiovascular health and diseases in China. Chin Med J (Engl). 136:2899–2908. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang H, Zhang H and Zou Z: Changing profiles of cardiovascular disease and risk factors in China: A secondary analysis for the Global Burden of Disease Study 2019. Chin Med J (Engl). 136:2431–2441. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang W, Liu Y, Liu J, Yin P, Wang L, Qi J, You J, Lin L, Meng S, Wang F, et al: Mortality and years of life lost of cardiovascular diseases in China, 2005-2020: Empirical evidence from national mortality surveillance system. Int J Cardiol. 340:105–112. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Yun CW and Lee SH: Enhancement of functionality and therapeutic efficacy of Cell-based therapy using mesenchymal stem cells for cardiovascular disease. Int J Mol Sci. 20:9822019. View Article : Google Scholar : PubMed/NCBI | |
|
Biasiolo M, Sales G, Lionetti M, Agnelli L, Todoerti K, Bisognin A, Coppe A, Romualdi C, Neri A and Bortoluzzi S: Impact of host genes and strand selection on miRNA and miRNA* expression. PLoS One. 6:e238542011. View Article : Google Scholar : PubMed/NCBI | |
|
Due H, Svendsen P, Bødker JS, Schmitz A, Bøgsted M, Johnsen HE, El-Galaly TC, Roug AS and Dybkær K: miR-155 as a biomarker in B-cell malignancies. Biomed Res Int. 2016:95130372016. View Article : Google Scholar : PubMed/NCBI | |
|
Chen L, Gao D, Shao Z, Zheng Q and Yu Q: miR-155 indicates the fate of CD4+ T cells. Immunol Lett. 224:40–49. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Yang X, Zeng X, Shu J, Bao H and Liu X: MiR-155 enhances phagocytosis of alveolar macrophages through the mTORC2/RhoA pathway. Medicine (Baltimore). 102:e345922023. View Article : Google Scholar : PubMed/NCBI | |
|
Tili E, Croce CM and Michaille JJ: miR-155: On the crosstalk between inflammation and cancer. Int Rev Immunol. 28:264–284. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Suofu Y, Wang X, He Y, Li F, Zhang Y, Carlisle DL and Friedlander RM: Mir-155 knockout protects against Ischemia/reperfusion-induced brain injury and hemorrhagic transformation. Neuroreport. 31:235–239. 2020. View Article : Google Scholar | |
|
Wu L, Pu L and Zhuang Z: miR-155-5p/FOXO3a promotes pulmonary fibrosis in rats by mediating NLRP3 inflammasome activation. Immunopharmacol Immunotoxicol. 45:257–267. 2023. View Article : Google Scholar | |
|
Cao RY, Li Q, Miao Y, Zhang Y, Yuan W, Fan L, Liu G, Mi Q and Yang J: The emerging role of MicroRNA-155 in cardiovascular diseases. Biomed Res Int. 2016:98692082016. View Article : Google Scholar : PubMed/NCBI | |
|
Chen JG, Xu XM, Ji H and Sun B: Inhibiting miR-155 protects against myocardial ischemia/reperfusion injury via targeted regulation of HIF-1α in rats. Iran J Basic Med Sci. 22:1050–1058. 2019.PubMed/NCBI | |
|
Guo J, Liu HB, Sun C, Yan XQ, Hu J, Yu J, Yuan Y and Du ZM: MicroRNA-155 promotes myocardial infarction-induced apoptosis by targeting RNA-Binding protein QKI. Oxid Med Cell Longev. 2019:45798062019. View Article : Google Scholar : PubMed/NCBI | |
|
Chen W, Wang L and Liu Z: MicroRNA-155 influences cell damage in ischemic stroke via TLR4/MYD88 signaling pathway. Bioengineered. 12:2449–2458. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Bai B, Ji Z, Wang F, Qin C, Zhou H, Li D and Wu Y: CTRP12 ameliorates post-myocardial infarction heart failure through down-regulation of cardiac apoptosis, oxidative stress and inflammation by influencing the TAK1-p38 MAPK/JNK pathway. Inflamm Res. 72:1375–1390. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Liang K, Zou G, Chen X, Shi S, Wang G, Zhang K, Li K and Zhai S: Inhibition of miR-155 attenuates abdominal aortic aneurysm in mice by regulating macrophage-mediated inflammation. Biosci Rep. 38:BSR201714322018. View Article : Google Scholar : PubMed/NCBI | |
|
Wu XY, Fan WD, Fang R and Wu GF: Regulation of microRNA-155 in endothelial inflammation by targeting nuclear factor (NF)-κB P65. J Cell Biochem. 115:1928–1936. 2014.PubMed/NCBI | |
|
Park M, Choi S, Kim S, Kim J, Lee DK, Park W, Kim T, Jung J, Hwang JY, Won MH, et al: NF-κB-responsive miR-155 induces functional impairment of vascular smooth muscle cells by downregulating soluble guanylyl cyclase. Exp Mol Med. 51:1–12. 2019. | |
|
Pena-Philippides JC, Caballero-Garrido E, Lordkipanidze T and Roitbak T: In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response. J Neuroinflammation. 13:2872016. View Article : Google Scholar : PubMed/NCBI | |
|
Wang X, Han W, Zhang Y, Zong Y, Tan N, Zhang Y, Li L, Liu C and Liu L: Soluble epoxide hydrolase inhibitor t-AUCB ameliorates vascular endothelial dysfunction by influencing the NF-κB/miR-155-5p/eNOS/NO/IκB Cycle in hypertensive rats. Antioxidants (Basel). 11:13722022. View Article : Google Scholar | |
|
Faccini J, Ruidavets JB, Cordelier P, Martins F, Maoret JJ, Bongard V, Ferrières J, Roncalli J, Elbaz M and Vindis C: Circulating miR-155, miR-145 and let-7c as diagnostic biomarkers of the coronary artery disease. Sci Rep. 7:429162017. View Article : Google Scholar : PubMed/NCBI | |
|
Huang YQ, Huang C, Zhang B and Feng YQ: Association of circulating miR-155 expression level and inflammatory markers with white coat hypertension. J Hum Hypertens. 34:397–403. 2020. View Article : Google Scholar | |
|
Zhang H, Chen G, Qiu W, Pan Q, Chen Y, Chen Y and Ma X: Plasma endothelial microvesicles and their carrying miRNA-155 serve as biomarkers for ischemic stroke. J Neurosci Res. 98:2290–2301. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Jin ZQ: MicroRNA targets and biomarker validation for diabetes-associated cardiac fibrosis. Pharmacol Res. 174:1059412021. View Article : Google Scholar : PubMed/NCBI | |
|
Sun G, Yan J, Noltner K, Feng J, Li H, Sarkis DA, Sommer SS and Rossi JJ: SNPs in human miRNA genes affect biogenesis and function. RNA. 15:1640–1651. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Tam W: Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA. Gene. 274:157–167. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Li C, He H, Zhu M, Zhao S and Li X: Molecular characterisation of porcine miR-155 and its regulatory roles in the TLR3/TLR4 pathways. Dev Comp Immunol. 39:110–116. 2013. View Article : Google Scholar | |
|
Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, et al: Requirement of bic/microRNA-155 for normal immune function. Science. 316:608–611. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, Rosenfeld MG, Briata P and Gherzi R: LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J. 23:2898–2908. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
O'Connell RM, Taganov KD, Boldin MP, Cheng G and Baltimore D: MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci USA. 104:1604–1609. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Guo Q, Zhang H, Zhang B, Zhang E and Wu Y: Tumor necrosis factor-alpha (TNF-α) enhances miR-155-Mediated endothelial senescence by targeting sirtuin1 (SIRT1). Med Sci Monit. 25:8820–8835. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Guo G, Zhong Z, Sun L, Liao L, Wang X, Cao Q and Chen H: Long non-coding RNA FLVCR1-AS1 sponges miR-155 to promote the tumorigenesis of gastric cancer by targeting c-Myc. Am J Transl Res. 11:793–805. 2019.PubMed/NCBI | |
|
Huang RS, Hu GQ, Lin B, Lin ZY and Sun CC: MicroRNA-155 silencing enhances inflammatory response and lipid uptake in oxidized Low-density Lipoprotein-stimulated human THP-1 macrophages. J Investig Med. 58:961–967. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Caballero-Garrido E, Pena-Philippides JC, Lordkipanidze T, Bragin D, Yang Y, Erhardt EB and Roitbak T: In Vivo inhibition of miR-155 promotes recovery after experimental mouse stroke. J Neurosci. 35:12446–12464. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Bruen R, Fitzsimons S and Belton O: miR-155 in the resolution of atherosclerosis. Front Pharmacol. 10:4632019. View Article : Google Scholar : PubMed/NCBI | |
|
Uva P, Da Sacco L, Del Cornò M, Baldassarre A, Sestili P, Orsini M, Palma A, Gessani S and Masotti A: Rat mir-155 generated from the lncRNA Bic is 'hidden' in the alternate genomic assembly and reveals the existence of novel mammalian miRNAs and clusters. RNA. 19:365–379. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, et al: Regulation of the germinal center response by microRNA-155. Science. 316:604–608. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Schliesser MG, Claus R, Hielscher T, Grimm C, Weichenhan D, Blaes J, Wiestler B, Hau P, Schramm J, Sahm F, et al: Prognostic relevance of miRNA-155 methylation in anaplastic glioma. Oncotarget. 7:82028–82045. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Heo I, Joo C, Cho J, Ha M, Han J and Kim VN: Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell. 32:276–284. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Lu C, Chen B, Chen C, Li H, Wang D, Tan Y and Weng H: CircNr1h4 regulates the pathological process of renal injury in salt-sensitive hypertensive mice by targeting miR-155-5p. J Cell Mol Med. 24:1700–1712. 2020. View Article : Google Scholar | |
|
Pasca S, Jurj A, Petrushev B, Tomuleasa C and Matei D: MicroRNA-155 implication in M1 polarization and the impact in inflammatory diseases. Front Immunol. 11:6252020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang J, Cheng C, Yuan X, He JT, Pan QH and Sun FY: microRNA-155 acts as an oncogene by targeting the tumor protein 53-induced nuclear protein 1 in esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 7:602–610. 2014.PubMed/NCBI | |
|
Li Y, Zhang L, Dong Z, Xu H, Yan L, Wang W, Yang Q and Chen C: MicroRNA-155-5p promotes tumor progression and contributes to paclitaxel resistance via TP53INP1 in human breast cancer. Pathol Res Pract. 220:1534052021. View Article : Google Scholar : PubMed/NCBI | |
|
Xiao L, Li X, Mu Z, Zhou J, Zhou P, Xie C and Jiang S: FTO inhibition enhances the antitumor effect of temozolomide by targeting MYC-miR-155/23a Cluster-MXI1 feedback circuit in glioma. Cancer Res. 80:3945–3958. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Costinean S, Zanesi N, Pekarsky Y, Tili E, Volinia S, Heerema N and Croce CM: Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA. 103:7024–7029. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Nazari-Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen RR, Heyll K, Gremse F, Kiessling F, Grommes J, et al: MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J Clin Invest. 122:4190–4202. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kurowska-Stolarska M, Alivernini S, Ballantine LE, Asquith DL, Millar NL, Gilchrist DS, Reilly J, Ierna M, Fraser AR, Stolarski B, et al: MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc Natl Acad Sci USA. 108:11193–11198. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wang G, Chen JJ, Deng WY, Ren K, Yin SH and Yu XH: CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway. Cell Death Dis. 12:2542021. View Article : Google Scholar | |
|
Jing H, Liu L, Jia Y, Yao H and Ma F: Overexpression of the long non-coding RNA Oprm1 alleviates apoptosis from cerebral Ischemia-reperfusion injury through the Oprm1/miR-155/GATA3 axis. Artif Cells Nanomed Biotechnol. 47:2431–2439. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Xue H, Hua LM, Guo M and Luo JM: SHIP1 is targeted by miR-155 in acute myeloid leukemia. Oncol Rep. 32:2253–2259. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Husain K, Villalobos-Ayala K, Laverde V, Vazquez OA, Miller B, Kazim S, Blanck G, Hibbs ML, Krystal G, Elhussin I, et al: Apigenin targets MicroRNA-155, enhances SHIP-1 expression, and augments anti-tumor responses in pancreatic cancer. Cancers (Basel). 14:36132022. View Article : Google Scholar : PubMed/NCBI | |
|
Faraoni I, Antonetti FR, Cardone J and Bonmassar E: miR-155 gene: A typical multifunctional microRNA. Biochim Biophys Acta. 1792:497–505. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Johansson J, Berg T, Kurzejamska E, Pang MF, Tabor V, Jansson M, Roswall P, Pietras K, Sund M, Religa P, et al: MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer. Oncogene. 32:5614–5624. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang D and Aguiar RC: MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-β1/SMAD5 signaling module. Blood. 123:86–93. 2014. View Article : Google Scholar : | |
|
Li DP, Fan J, Wu YJ, Xie YF, Zha JM and Zhou XM: MiR-155 up-regulated by TGF-β promotes epithelial-mesenchymal transition, invasion and metastasis of human hepatocellular carcinoma cells in vitro. Am J Transl Res. 9:2956–2965. 2017. | |
|
Ke F, Wang H, Geng J, Jing X, Fang F, Fang C and Zhang BH: MiR-155 promotes inflammation and apoptosis via targeting SIRT1 in hypoxic-ischemic brain damage. Exp Neurol. 362:1143172023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhai Y, Liu B, Wu L, Zou M, Mei X and Mo X: Pachymic acid prevents neuronal cell damage induced by hypoxia/reoxygenation via miR-155/NRF2/HO-1 axis. Acta Neurobiol Exp (Wars). 82:197–206. 2022. | |
|
Zhang W, Wang L, Wang R, Duan Z and Wang H: A blockade of microRNA-155 signal pathway has a beneficial effect on neural injury after intracerebral haemorrhage via reduction in neuroinflammation and oxidative stress. Arch Physiol Biochem. 128:1235–1241. 2022. View Article : Google Scholar | |
|
Sun L, Ji S and Xing J: Inhibition of microRNA-155 alleviates neurological dysfunction following transient global ischemia and contribution of neuroinflammation and oxidative stress in the hippocampus. Curr Pharm Des. 25:4310–4317. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Yang J, Si D, Zhao Y, He C and Yang P: S-amlodipine improves endothelial dysfunction via the RANK/RANKL/OPG system by regulating microRNA-155 in hypertension. Biomed Pharmacother. 114:1087992019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu Y, Xian X, Wang Z, Bi Y, Chen Q, Han X, Tang D and Chen R: Research progress on the relationship between atherosclerosis and inflammation. Biomolecules. 8:802018. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng B, Yin WN, Suzuki T, Zhang XH, Zhang Y, Song LL, Jin LS, Zhan H, Zhang H, Li JS and Wen JK: Exosome-Mediated miR-155 transfer from smooth muscle cells to endothelial cells induces endothelial injury and promotes atherosclerosis. Mol Ther. 25:1279–1294. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
González-López P, Ares-Carral C, López-Pastor AR, Infante-Menéndez J, González Illaness T, Vega de Ceniga M, Esparza L, Beneit N, Martín-Ventura JL, Escribano Ó and Gómez-Hernández A: Implication of miR-155-5p and miR-143-3p in the vascular insulin resistance and instability of human and experimental atherosclerotic plaque. Int J Mol Sci. 23:102532022. View Article : Google Scholar : PubMed/NCBI | |
|
Gimbrone MA Jr and García-Cardeña G: Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res. 118:620–636. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ota H, Eto M, Ogawa S, Iijima K, Akishita M and Ouchi Y: SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis. J Atheroscler Thromb. 17:431–435. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Hong FF, Liang XY, Liu W, Lv S, He SJ, Kuang HB and Yang SL: Roles of eNOS in atherosclerosis treatment. Inflamm Res. 68:429–441. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Sun HX, Zeng DY, Li RT, Pang RP, Yang H, Hu YL, Zhang Q, Jiang Y, Huang LY, Tang YB, et al: Essential role of microRNA-155 in regulating Endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase. Hypertension. 60:1407–1414. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu N, Zhang D, Chen S, Liu X, Lin L, Huang X, Guo Z, Liu J, Wang Y, Yuan W and Qin Y: Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration. Atherosclerosis. 215:286–293. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Lee HJ, Lee EJ and Seo M: Galpha12 protects vascular endothelial cells from serum Withdrawal-induced apoptosis through regulation of miR-155. Yonsei Med J. 57:247–253. 2016. View Article : Google Scholar : | |
|
Zhao Y, Rao W, Wan Y, Yang X, Wang G, Deng J, Dai M and Liu Q: Overexpression of microRNA-155 alleviates palmitate-induced vascular endothelial cell injury in human umbilical vein endothelial cells by negatively regulating the Wnt signaling pathway. Mol Med Rep. 20:3527–3534. 2019.PubMed/NCBI | |
|
Wei DH, Jia XY, Liu YH, Guo FX, Tang ZH, Li XH, Wang Z, Liu LS, Wang GX, Jian ZS and Ruan CG: Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: Potential role in atherosclerosis. Int J Mol Med. 31:400–406. 2013. View Article : Google Scholar | |
|
Hu M, Ladowski JM and Xu H: The role of autophagy in vascular endothelial cell health and physiology. Cells. 13:8252024. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang X, Ma C, Gao Y, Cui H, Zheng Y, Li J, Zong W and Zhang Q: Tongxinluo attenuates atherosclerosis by inhibiting ROS/NLRP3/caspase-1-mediated endothelial cell pyroptosis. J Ethnopharmacol. 304:1160112023. View Article : Google Scholar | |
|
Zhang Z, Pan X, Yang S, Ma A, Wang K, Wang Y, Li T and Liu S: miR-155 Promotes ox-LDL-Induced autophagy in human umbilical vein endothelial cells. Mediators Inflamm. 2017:91748012017. View Article : Google Scholar : PubMed/NCBI | |
|
Yin S, Yang S, Pan X, Ma A, Ma J, Pei H, Dong Y, Li S, Li W and Bi X: MicroRNA-155 promotes ox-LDL-induced autophagy in human umbilical vein endothelial cells by targeting the PI3K/Akt/mTOR pathway. Mol Med Rep. 18:2798–2806. 2018.PubMed/NCBI | |
|
McCully KS: Homocysteine and the pathogenesis of atherosclerosis. Expert Rev Clin Pharmacol. 8:211–219. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Witucki Ł and Jakubowski H: Homocysteine metabolites inhibit autophagy by upregulating miR-21-5p, miR-155-5p, miR-216-5p, and miR-320c-3p in human vascular endothelial cells. Sci Rep. 14:71512024. View Article : Google Scholar : PubMed/NCBI | |
|
Alonso-Piñeiro JA, Gonzalez-Rovira A, Sánchez-Gomar I, Moreno JA and Durán-Ruiz MC: Nrf2 and heme Oxygenase-1 involvement in atherosclerosis related oxidative stress. Antioxidants (Basel). 10:14632021. View Article : Google Scholar : PubMed/NCBI | |
|
Pulkkinen KH, Ylä-Herttuala S and Levonen AL: Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells. Free Radic Biol Med. 51:2124–2131. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Gou L, Liu G, Ma R, Regmi A, Zeng T, Zheng J, Zhong X and Chen L: High fat-induced inflammation in vascular endothelium can be improved by Abelmoschus esculentus and metformin via increasing the expressions of miR-146a and miR-155. Nutr Metab (Lond). 17:352020. View Article : Google Scholar : PubMed/NCBI | |
|
Yang D, Wang J, Xiao M, Zhou T and Shi X: Role of Mir-155 in controlling HIF-1α level and promoting endothelial cell maturation. Sci Rep. 6:353162016. View Article : Google Scholar | |
|
Frismantiene A, Philippova M, Erne P and Resink TJ: Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity. Cell Signal. 52:48–64. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Choi S, Park M, Kim J, Park W, Kim S, Lee DK, Hwang JY, Choe J, Won MH, Ryoo S, et al: TNF-α elicits phenotypic and functional alterations of vascular smooth muscle cells by miR-155-5p-dependent down-regulation of cGMP-dependent kinase 1. J Biol Chem. 293:14812–14822. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chen L, Zheng SY, Yang CQ, Ma BM and Jiang D: MiR-155-5p inhibits the proliferation and migration of VSMCs and HUVECs in atherosclerosis by targeting AKT1. Eur Rev Med Pharmacol Sci. 23:2223–2233. 2019.PubMed/NCBI | |
|
Tong Y, Zhou MH, Li SP, Zhao HM, Zhang YR, Chen D, Wu YX and Pang QF: MiR-155-5p attenuates vascular smooth muscle cell oxidative stress and migration via inhibiting BACH1 expression. Biomedicines. 11:16792023. View Article : Google Scholar : PubMed/NCBI | |
|
Tang Y, Song H, Shen Y, Yao Y, Yu Y, Wei G, Long B and Yan W: MiR-155 acts as an inhibitory factor in atherosclerosis-associated arterial pathogenesis by down-regulating NoxA1 related signaling pathway in ApoE(-/-) mouse. Cardiovasc Diagn Ther. 11:1–13. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
He S, Wu C, Xiao J, Li D, Sun Z and Li M: Endothelial extracellular vesicles modulate the macrophage phenotype: Potential implications in atherosclerosis. Scand J Immunol. 87:e126482018. View Article : Google Scholar : PubMed/NCBI | |
|
Chistiakov DA, Melnichenko AA, Myasoedova VA, Grechko AV and Orekhov AN: Mechanisms of foam cell formation in atherosclerosis. J Mol Med (Berl). 95:1153–1165. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang F, Zhao J, Sun D and Wei N: MiR-155 inhibits transformation of macrophages into foam cells via regulating CEH expression. Biomed Pharmacother. 104:645–651. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Li X, Kong D, Chen H, Liu S, Hu H, Wu T, Wang J, Chen W, Ning Y, Li Y and Lu Z: miR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1. Sci Rep. 6:217892016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu J, Chen T, Yang L, Li Z, Wong MM, Zheng X, Pan X, Zhang L and Yan H: Regulation of microRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10. PLoS One. 7:e465512012. View Article : Google Scholar : PubMed/NCBI | |
|
Ye J, Guo R, Shi Y, Qi F, Guo C and Yang L: miR-155 Regulated inflammation response by the SOCS1-STAT3-PDCD4 axis in atherogenesis. Mediators Inflamm. 2016:80601822016. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng J, Wang W, Hong T, Yang S, Shen J and Liu C: Suppression of microRNA-155 exerts an anti-inflammatory effect on CD4+ T cell-mediated inflammatory response in the pathogenesis of atherosclerosis. Acta Biochim Biophys Sin (Shanghai). 52:654–664. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Peng Q, Yin R, Zhu X, Jin L, Wang J, Pan X and Ma A: miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE(-/-) mice. J Physiol Biochem. 78:365–375. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Li X, Wang D, Jiang X, Zhang M and Lv K: Serum exosome microRNA panel as a noninvasive biomarker for molecular diagnosis of fulminant myocarditis. Mol Ther Methods Clin Dev. 20:142–151. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Oh JH, Kim GB and Seok H: Implication of microRNA as a potential biomarker of myocarditis. Clin Exp Pediatr. 65:230–238. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Lewandowski P, Goławski M, Baron M, Reichman-Warmusz E and Wojnicz R: A systematic review of miRNA and cfDNA as potential biomarkers for liquid biopsy in myocarditis and inflammatory dilated cardiomyopathy. Biomolecules. 12L:14762022. View Article : Google Scholar | |
|
Aleshcheva G, Baumeier C, Harms D, Bock CT, Escher F and Schultheiss HP: MicroRNAs as novel biomarkers and potential therapeutic options for inflammatory cardiomyopathy. ESC Heart Fail. 10:3410–3418. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Bao JL and Lin L: MiR-155 and miR-148a reduce cardiac injury by inhibiting NF-κB pathway during acute viral myocarditis. Eur Rev Med Pharmacol Sci. 18:2349–2356. 2014.PubMed/NCBI | |
|
Zhang Y, Zhang M, Li X, Tang Z, Wang X, Zhong M, Suo Q, Zhang Y and Lv K: Silencing MicroRNA-155 attenuates cardiac injury and dysfunction in viral myocarditis via promotion of M2 phenotype polarization of macrophages. Sci Rep. 6:226132016. View Article : Google Scholar : PubMed/NCBI | |
|
Yan L, Hu F, Yan X, Wei Y, Ma W, Wang Y, Lu S and Wang Z: Inhibition of microRNA-155 ameliorates experimental autoimmune myocarditis by modulating Th17/Treg immune response. J Mol Med (Berl). 94:1063–1079. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Dai X, Qi J, Ao Y, Yang C and Li Y: Astragalus mongholicus (Fisch.) bge improves peripheral treg cell immunity imbalance in the children with viral myocarditis by reducing the levels of miR-146b and miR-155. Front Pediatr. 6:1392018. View Article : Google Scholar : PubMed/NCBI | |
|
Derda AA, Thum S, Lorenzen JM, Bavendiek U, Heineke J, Keyser B, Stuhrmann M, Givens RC, Kennel PJ, Schulze PC, et al: Blood-based microRNA signatures differentiate various forms of cardiac hypertrophy. Int J Cardiol. 196:115–122. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
He W, Huang H, Xie Q, Wang Z, Fan Y, Kong B, Huang D and Xiao Y: MiR-155 knockout in fibroblasts improves cardiac remodeling by targeting tumor protein p53-Inducible nuclear protein 1. J Cardiovasc Pharmacol Ther. 21:423–435. 2016. View Article : Google Scholar | |
|
Kelly M, Bagnall RD, Peverill RE, Donelan L, Corben L, Delatycki MB and Semsarian C: A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. J Mol Cell Cardiol. 51:848–854. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
de Oliveira G, Freire PP, Omoto ACM, Cury SS, Fuziwara CS, Kimura ET, Dal-Pai-Silva M and Carvalho RF: Osteoglycin post-transcriptional regulation by miR-155 induces cellular architecture changes in H9c2 cardiomyoblasts. Gene. 676:9–15. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Zhou Y, Cao Z, Tong XZ, Xie HQ, Luo T, Hua XP and Wang HQ: miR-155 functions downstream of angiotensin II receptor subtype 1 and calcineurin to regulate cardiac hypertrophy. Exp Ther Med. 12:1556–1562. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Seok HY, Chen J, Kataoka M, Huang ZP, Ding J, Yan J, Hu X and Wang DZ: Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy. Circ Res. 114:1585–1595. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Yu H, Qin L, Peng Y, Bai W and Wang Z: Exosomes derived from hypertrophic cardiomyocytes induce inflammation in macrophages via miR-155 mediated MAPK Pathway. Front Immunol. 11:6060452020. View Article : Google Scholar | |
|
Wang B, Wang ZM, Ji JL, Gan W, Zhang A, Shi HJ, Wang H, Lv L, Li Z, Tang T, et al: Macrophage-derived exosomal Mir-155 regulating cardiomyocyte pyroptosis and hypertrophy in uremic cardiomyopathy. JACC Basic Transl Sci. 5:148–166. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Feng T, Duan S, Shi Y, Li S, Zhang X and Zhang L: miR-155 promotes fibroblast-like synoviocyte proliferation and inflammatory cytokine secretion in rheumatoid arthritis by targeting FOXO3a. Exp Ther Med. 19:1288–1296. 2020.PubMed/NCBI | |
|
Fan Y, Liu L, Fang K, Huang T, Wan L, Liu Y, Zhang S, Yan D, Li G, Gao Y, et al: Resveratrol Ameliorates cardiac hypertrophy by Down-regulation of miR-155 through activation of breast cancer type 1 susceptibility protein. J Am Heart Assoc. 5:e0026482016. View Article : Google Scholar : PubMed/NCBI | |
|
Yuan Y, Wang J, Chen Q, Wu Q, Deng W, Zhou H and Shen D: Long non-coding RNA cytoskeleton regulator RNA (CYTOR) modulates pathological cardiac hypertrophy through miR-155-mediated IKKi signaling. Biochim Biophys Acta Mol Basis Dis. 1865:1421–1427. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Murphy A and Goldberg S: Mechanical complications of myocardial infarction. Am J Med. 135:1401–1409. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Bentzon JF, Otsuka F, Virmani R and Falk E: Mechanisms of plaque formation and rupture. Circ Res. 114:1852–1866. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wang C, Zhang C, Liu L, A X, Chen B, Li Y and Du J: Macrophage-Derived mir-155-Containing exosomes suppress fibroblast proliferation and promote fibroblast inflammation during cardiac injury. Mol Ther. 25:192–204. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Hu J, Huang CX, Rao PP, Zhou JP, Wang X, Tang L, Liu MX and Zhang GG: Inhibition of microRNA-155 attenuates sympathetic neural remodeling following myocardial infarction via reducing M1 macrophage polarization and inflammatory responses in mice. Eur J Pharmacol. 851:122–132. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Hu J, Huang CX, Rao PP, Cao GQ, Zhang Y, Zhou JP, Zhu LY, Liu MX and Zhang GG: MicroRNA-155 inhibition attenuates endoplasmic reticulum stress-induced cardiomyocyte apoptosis following myocardial infarction via reducing macrophage inflammation. Eur J Pharmacol. 857:1724492019. View Article : Google Scholar : PubMed/NCBI | |
|
Palatinus JA, Valdez S, Taylor L, Whisenant C, Selzman CH, Drakos SG, Ranjan R, Hong T, Saffitz JE and Shaw RM: GJA1-20k rescues Cx43 localization and arrhythmias in arrhythmogenic cardiomyopathy. Circ Res. 132:744–746. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Yang HT, Li LL, Li SN, Wu JT, Chen K, Song WF, Zhang GB, Ma JF, Fu HX, Cao S, et al: MicroRNA-155 inhibition attenuates myocardial infarction-induced connexin 43 degradation in cardiomyocytes by reducing pro-inflammatory macrophage activation. Cardiovasc Diagn Ther. 12:325–339. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu W, Du W, Duan R, Liu Y, Zong B, Jin X, Dong Z, Wang H, Shahab S, Wang H, et al: miR-873-5p suppression reinvigorates aging mesenchymal stem cells and improves cardiac repair after myocardial infarction. ACS Pharmacol Transl Sci. 7:743–756. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Hong Y, He H, Jiang G, Zhang H, Tao W, Ding Y, Yuan D, Liu J, Fan H, Lin F, et al: miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction. Aging Cell. 19:e131282020. View Article : Google Scholar : PubMed/NCBI | |
|
Lu Q, Shen Q, Su J, Li X, Xia B and Tang A: Inhibition of mir-155-5p alleviates cardiomyocyte pyroptosis induced by hypoxia/reoxygenation via targeting SIRT1-mediated activation of the NLRP3 inflammasome. J Cardiothorac Surg. 20:1352025. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang H, Ma J, Liu F and Zhang J: Long non-coding RNA XIST promotes the proliferation of cardiac fibroblasts and the accumulation of extracellular matrix by sponging microRNA-155-5p. Exp Ther Med. 21:4772021. View Article : Google Scholar : PubMed/NCBI | |
|
Schumacher D, Curaj A, Simsekyilmaz S, Schober A, Liehn EA and Mause SF: miR155 deficiency reduces myofibroblast density but fails to improve cardiac function after myocardial infarction in dyslipidemic mouse model. Int J Mol Sci. 22:54802021. View Article : Google Scholar : PubMed/NCBI | |
|
Xie W, Li P, Wang Z, Chen J, Lin Z, Liang X and Mo Y: Rosuvastatin may reduce the incidence of cardiovascular events in patients with acute coronary syndromes receiving percutaneous coronary intervention by suppressing miR-155/SHIP-1 signaling pathway. Cardiovasc Ther. 32:276–282. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Li X, Liu R, Liu W, Liu X, Fan Z, Cui J, Wu Y, Yin H and Lin Q: Panax quinquefolium L. and Salvia miltiorrhiza Bunge. enhances angiogenesis by regulating the miR-155-5p/HIF-1α/VEGF axis in acute myocardial infarction. Drug Des Devel Ther. 17:3249–3267. 2023. View Article : Google Scholar : | |
|
Zhang M, Liu Q, Meng H, Duan H, Liu X, Wu J, Gao F, Wang S, Tan R and Yuan J: Ischemia-reperfusion injury: Molecular mechanisms and therapeutic targets. Signal Transduct Target Ther. 9:122024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Q, Jia M, Wang Y, Wang Q and Wu J: Cell death mechanisms in cerebral ischemia-reperfusion injury. Neurochem Res. 47:3525–3542. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Li L, Wang Z, Zhang J and Zhou Z: Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention. Microvasc Res. 149:1045652023. View Article : Google Scholar : PubMed/NCBI | |
|
Eisenhardt SU, Weiss JB, Smolka C, Maxeiner J, Pankratz F, Bemtgen X, Kustermann M, Thiele JR, Schmidt Y, Bjoern Stark G, et al: MicroRNA-155 aggravates ischemia-reperfusion injury by modulation of inflammatory cell recruitment and the respiratory oxidative burst. Basic Res Cardiol. 110:322015. View Article : Google Scholar : PubMed/NCBI | |
|
Xi J, Li QQ, Li BQ and Li N: miR-155 inhibition represents a potential valuable regulator in mitigating myocardial hypoxia/reoxygenation injury through targeting BAG5 and MAPK/JNK signaling. Mol Med Rep. 21:1011–1020. 2020.PubMed/NCBI | |
|
Huang G, Hao F and Hu X: Downregulation of microRNA-155 stimulates sevoflurane-mediated cardioprotection against myocardial ischemia/reperfusion injury by binding to SIRT1 in mice. J Cell Biochem. 120:15494–15505. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Greco R, Demartini C, Zanaboni AM, Blandini F, Amantea D and Tassorelli C: Endothelial nitric oxide synthase inhibition triggers inflammatory responses in the brain of male rats exposed to ischemia-reperfusion injury. J Neurosci Res. 96:151–159. 2018. View Article : Google Scholar | |
|
Liu M, Fu D, Gao T, Jiang H, Yang P and Li X: The low expression of miR-155 promotes the expression of SHP2 by inhibiting the activation of the ERK1/2 pathway and improves cell pyroptosis induced by I/R in mice. Aging (Albany NY). 16:4778–4788. 2024.PubMed/NCBI | |
|
Jiang T, Zhou S, Li X, Song J, An T, Huang X, Ping X and Wang L: MicroRNA-155 induces protection against cerebral ischemia/reperfusion injury through regulation of the Notch pathway in vivo. Exp Ther Med. 18:605–613. 2019.PubMed/NCBI | |
|
Zhang L, Liu C, Huang C, Xu X and Teng J: miR-155 knockdown protects against cerebral ischemia and reperfusion injury by targeting MafB. Biomed Res Int. 2020:64582042020. View Article : Google Scholar : PubMed/NCBI | |
|
Shi Y, Li K, Xu K and Liu QH: MiR-155-5p accelerates cerebral ischemia-reperfusion injury via targeting DUSP14 by regulating NF-κB and MAPKs signaling pathways. Eur Rev Med Pharmacol Sci. 24:1408–1419. 2020.PubMed/NCBI | |
|
Shi Y, Li Z, Li K and Xu K: miR-155-5p accelerates cerebral ischemia-reperfusion inflammation injury and cell pyroptosis via DUSP14/TXNIP/NLRP3 pathway. Acta Biochim Pol. 69:787–793. 2022.PubMed/NCBI | |
|
Xue Y, Wang Y, Chen T, Peng L, Wang C, Xue G and Yu S: DJ-1 regulates astrocyte activation through miR-155/SHP-1 signaling in cerebral ischemia/reperfusion injury. J Neurochem. 169:e162302025. View Article : Google Scholar | |
|
Tanai E and Frantz S: Pathophysiology of heart failure. Compr Physiol. 6:187–214. 2015. View Article : Google Scholar | |
|
McMurray JJ and Pfeffer MA: Heart failure. Lancet. 365:1877–1889. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Mosterd A and Hoes AW: Clinical epidemiology of heart failure. Heart. 93:1137–1146. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Su H, Zhu Y, Cao Y and Ma X: ETS2 and microRNA-155 regulate the pathogenesis of heart failure through targeting and regulating GPR18 expression. Exp Ther Med. 19:3469–3478. 2020.PubMed/NCBI | |
|
Lin B, Zhao H, Li L, Zhang Z, Jiang N, Yang X, Zhang T, Lian B, Liu Y, Zhang C, et al: Sirt1 improves heart failure through modulating the NF-κB p65/microRNA-155/BNDF signaling cascade. Aging (Albany NY). 13:14482–14498. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Gao L, Li T, Li S, Song Z, Chang Y and Yuan L: Schisandrin A protects against isoproterenol-induced chronic heart failure via miR-155. Mol Med Rep. 25:242022. View Article : Google Scholar | |
|
Luo Y, Deng X, Chen Q, Cai Y, Bie M, Zhang Y, Peng L, Yao K, Chen X and Cai H: Up-regulation of miR-155 protects against chronic heart failure by inhibiting HIF-1α. Am J Transl Res. 15:6425–6436. 2023. | |
|
Heymans S, Corsten MF, Verhesen W, Carai P, van Leeuwen RE, Custers K, Peters T, Hazebroek M, Stöger L, Wijnands E, et al: Macrophage microRNA-155 promotes cardiac hypertrophy and failure. Circulation. 128:1420–1432. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng L, Xu CC, Chen WD, Shen WL, Ruan CC, Zhu LM, Zhu DL and Gao PJ: MicroRNA-155 regulates angiotensin II type 1 receptor expression and phenotypic differentiation in vascular adventitial fibroblasts. Biochem Biophys Res Commun. 400:483–488. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Shi L and Fleming I: One miR level of control: microRNA-155 directly regulates endothelial nitric oxide synthase mRNA and protein levels. Hypertension. 60:1381–1382. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Touyz RM, Alves-Lopes R, Rios FJ, Camargo LL, Anagnostopoulou A, Arner A and Montezano AC: Vascular smooth muscle contraction in hypertension. Cardiovasc Res. 114:529–539. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Xu D, Liao R, Wang XX and Cheng Z: Effects of miR-155 on hypertensive rats via regulating vascular mesangial hyperplasia. Eur Rev Med Pharmacol Sci. 22:7431–7438. 2018.PubMed/NCBI | |
|
Lai KN, Leung JCK and Tang SCW: The renin-angiotensin system. Contrib Nephrol. 170:135–144. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, Scalia R and Eguchi S: Angiotensin II signal transduction: An update on mechanisms of physiology and pathophysiology. Physiol Rev. 98:1627–1738. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
DuPont JJ, McCurley A, Davel AP, McCarthy J, Bender SB, Hong K, Yang Y, Yoo JK, Aronovitz M, Baur WE, et al: Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging. JCI Insight. 1:e889422016. View Article : Google Scholar : PubMed/NCBI | |
|
Theilig F and Wu Q: ANP-induced signaling cascade and its implications in renal pathophysiology. Am J Physiol Renal Physiol. 308:F1047–1055. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Vandenwijngaert S, Ledsky CD, Agha O, Wu C, Hu D, Bagchi A, Domian IJ, Buys ES, Newton-Cheh C and Bloch DB: MicroRNA-425 and microRNA-155 cooperatively regulate atrial natriuretic peptide expression and cGMP production. PLoS One. 13:e01966972018. View Article : Google Scholar : PubMed/NCBI | |
|
Stonesifer C, Corey S, Ghanekar S, Diamandis Z, Acosta SA and Borlongan CV: Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms. Prog Neurobiol. 158:94–131. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Putaala J: Ischemic stroke in young adults. Continuum (Minneap Minn). 26:386–414. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Choi GH, Ko KH, Kim JO, Kim J, Oh SH, Han IB, Cho KG, Kim OJ, Bae J and Kim NK: Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke. Int J Mol Med. 38:345–356. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Xing G, Luo Z, Zhong C, Pan X and Xu X: Influence of miR-155 on cell apoptosis in rats with ischemic stroke: Role of the ras homolog enriched in brain (Rheb)/mTOR pathway. Med Sci Monit. 22:5141–5153. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Zhang N, Wang S and Wen Y: MicroRNA-155 regulates inflammatory response in ischemic cerebral tissues through autophagy. Curr Neurovasc Res. 15:103–110. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Adly Sadik N, Ahmed Rashed L and Ahmed Abd-El Mawla M: Circulating miR-155 and JAK2/STAT3 axis in acute ischemic stroke patients and its relation to Post-ischemic inflammation and associated ischemic stroke risk factors. Int J Gen Med. 14:1469–1484. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Huang W, Hong Q, Wang H, Zhu Z and Gong S: MicroRNA-155 inhibition activates Wnt/β-Catenin signaling to restore Th17/Treg cell balance and protect against acute ischemic stroke. eNeuro. 12:ENEURO.0347-24.2024. 2025. View Article : Google Scholar | |
|
Wang J, Li D, Hou J and Lei H: Protective effects of geniposide and ginsenoside Rg1 combination treatment on rats following cerebral ischemia are mediated via microglial microRNA-155-5p inhibition. Mol Med Rep. 17:3186–3193. 2018. | |
|
Zhang JK, Li Y, Yu ZT, Jiang JW, Tang H, Tu GL and Xia Y: OIP5-AS1 inhibits oxidative stress and inflammation in ischemic stroke through miR-155-5p/IRF2BP2 axis. Neurochem Res. 48:1382–1394. 2023. | |
|
Bossone E and Eagle KA: Epidemiology and management of aortic disease: Aortic aneurysms and acute aortic syndromes. Nat Rev Cardiol. 18:331–348. 2021. View Article : Google Scholar | |
|
Spin JM, Li DY, Maegdefessel L and Tsao PS: Non-coding RNAs in aneurysmal aortopathy. Vascul Pharmacol. 114:110–121. 2019. View Article : Google Scholar | |
|
Hu J, Huang S, Liu X, Zhang Y, Wei S and Hu X: miR-155: An important role in inflammation response. J Immunol Res. 2022:74372812022. View Article : Google Scholar : PubMed/NCBI | |
|
Yang X, Peng J, Pang J, Wan W and Chen L: A functional polymorphism in the promoter region of miR-155 predicts the risk of intracranial hemorrhage caused by rupture intracranial aneurysm. J Cell Biochem. 120:18618–18628. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Feng Z, Zhang X, Li L, Wang C, Feng M, Zhao K, Zhao R, Liu J and Fang Y: Tumor-associated macrophage-derived exosomal microRNA-155-5p stimulates intracranial aneurysm formation and macrophage infiltration. Clin Sci (Lond). 133:2265–2282. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang RL, Wang WM, Li JQ, Li RW, Zhang J, Wu Y and Liu Y: The role of miR-155 in cardiovascular diseases: Potential diagnostic and therapeutic targets. Int J Cardiol Cardiovasc Risk Prev. 24:2003552025.PubMed/NCBI | |
|
Yang WW, Li QX, Wang F, Zhang XR, Zhang XL, Wang M, Xue D, Zhao Y and Tang L: Exosomal miR-155-5p promote the occurrence of carotid atherosclerosis. J Cell Mol Med. 28:e701872024. View Article : Google Scholar : PubMed/NCBI | |
|
Eshraghi R, Rafiei M, Hadian Jazi Z, Shafie D, Raisi A and Mirzaei H: MicroRNA-155 and exosomal microRNA-155: Small pieces in the cardiovascular diseases puzzle. Pathol Res Pract. 257:1552742024. View Article : Google Scholar | |
|
Kazimierczyk E, Eljaszewicz A, Zembko P, Tarasiuk E, Rusak M, Kulczynska-Przybik A, Lukaszewicz-Zajac M, Kaminski K, Mroczko B, Szmitkowski M, et al: The relationships among monocyte subsets, miRNAs and inflammatory cytokines in patients with acute myocardial infarction. Pharmacol Rep. 71:73–81. 2019. View Article : Google Scholar | |
|
Fitzsimons S, Oggero S, Bruen R, McCarthy C, Strowitzki MJ, Mahon NG, Ryan N, Brennan EP, Barry M, Perretti M, et al: microRNA-155 is decreased during atherosclerosis regression and is increased in urinary extracellular vesicles during atherosclerosis progression. Front Immunol. 11:5765162020. View Article : Google Scholar | |
|
Obradovic D, Rommel KP, Blazek S, Klingel K, Gutberlet M, Lücke C, Büttner P, Thiele H, Adams V, Lurz P, et al: The potential role of plasma miR-155 and miR-206 as circulatory biomarkers in inflammatory cardiomyopathy. ESC Heart Fail. 8:1850–1860. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Yao R, Ma Y, Du Y, Liao M, Li H, Liang W, Yuan J, Ma Z, Yu X, Xiao H and Liao Y: The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome. Cell Mol Immunol. 8:486–495. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Q, Liu L, Chen X, Wang T, Zhou H, Huang H, Qing L and Luo P: Noninvasive prognosis of postmyocardial infarction using urinary miRNA ultratrace detection based on Single-Target DNA-functionalized AuNPs. ACS Appl Mater Interfaces. 14:3633–3642. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Tijsen AJ, Pinto YM and Creemers EE: Non-cardiomyocyte microRNAs in heart failure. Cardiovasc Res. 93:573–582. 2012. View Article : Google Scholar | |
|
Ikitimur B, Cakmak HA, Coskunpinar E, Barman HA and Vural VA: The relationship between circulating microRNAs and left ventricular mass in symptomatic heart failure patients with systolic dysfunction. Kardiol Pol. 73:740–746. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Ding H, Wang Y, Hu L, Xue S, Wang Y, Zhang L, Zhang Y, Qi H, Yu H, Aung LHH, et al: Combined detection of miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 for screening of early heart failure diseases. Biosci Rep. 40:BSR201916532020. View Article : Google Scholar : PubMed/NCBI | |
|
Kin K, Miyagawa S, Fukushima S, Shirakawa Y, Torikai K, Shimamura K, Daimon T, Kawahara Y, Kuratani T and Sawa Y: Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm. J Am Heart Assoc. 1:e0007452012. View Article : Google Scholar | |
|
Biros E, Moran CS, Wang Y, Walker PJ, Cardinal J and Golledge J: microRNA profiling in patients with abdominal aortic aneurysms: The significance of miR-155. Clin Sci (Lond). 126:795–803. 2014. View Article : Google Scholar | |
|
Mashima R: Physiological roles of miR-155. Immunology. 145:323–333. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Seto AG, Beatty X, Lynch JM, Hermreck M, Tetzlaff M, Duvic M and Jackson AL: Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol. 183:428–444. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Anastasiadou E, Seto AG, Beatty X, Hermreck M, Gilles ME, Stroopinsky D, Pinter-Brown LC, Pestano L, Marchese C, Avigan D, et al: Cobomarsen, an oligonucleotide inhibitor of miR-155, slows DLBCL tumor cell growth in vitro and in vivo. Clin Cancer Res. 27:1139–1149. 2021. View Article : Google Scholar : | |
|
Yan Q, Chen J, Li W, Bao C and Fu Q: Targeting miR-155 to treat experimental scleroderma. Sci Rep. 6:203142016. View Article : Google Scholar : PubMed/NCBI | |
|
Tian FJ, An LN, Wang GK, Zhu JQ, Li Q, Zhang YY, Zeng A, Zou J, Zhu RF, Han XS, et al: Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis. Cardiovasc Res. 103:100–110. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Tokgozoglu L and Kayikcioglu M: Familial hypercholesterolemia: Global burden and approaches. Curr Cardiol Rep. 23:1512021. View Article : Google Scholar : PubMed/NCBI | |
|
Yao R, Ma YL, Liang W, Li HH, Ma ZJ, Yu X and Liao YH: MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1. PLoS One. 7:e460822012. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao L, Ouyang Y, Bai Y, Gong J and Liao H: miR-155-5p inhibits the viability of vascular smooth muscle cell via targeting FOS and ZIC3 to promote aneurysm formation. Eur J Pharmacol. 853:145–152. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Ertl HCJ: Immunogenicity and toxicity of AAV gene therapy. Front Immunol. 13:9758032022. View Article : Google Scholar : PubMed/NCBI | |
|
Kahil N, Abouzeinab NS, Hussein MAA and Khalil MI: Intraperitoneal hepatorenal toxicity of zinc oxide and nickel oxide nanoparticles in rats: A systematic review. Nanotoxicology. 18:583–598. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Wei Y, Yan X, Yan L, Hu F, Ma W, Wang Y, Lu S, Zeng Q and Wang Z: Inhibition of microRNA-155 ameliorates cardiac fibrosis in the process of angiotensin II-induced cardiac remodeling. Mol Med Rep. 16:7287–7296. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Tang H, Mao J, Ye X, Zhang F, Kerr WG, Zheng T and Zhu Z: SHIP-1, a target of miR-155, regulates endothelial cell responses in lung fibrosis. FASEB J. 34:2011–2023. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Kalkusova K, Taborska P, Stakheev D and Smrz D: The role of miR-155 in antitumor immunity. Cancers (Basel). 14:54142022. View Article : Google Scholar : PubMed/NCBI | |
|
Ghoumari AM, Rixe O, Yarovoi SV, Zerrouqi A, Mouawad R, Poynard T, Opolon P, Khayat D and Soubrane C: Gene transfer in hepatocarcinoma cell lines: In vitro optimization of a virus-free system. Gene Ther. 3:483–490. 1996.PubMed/NCBI | |
|
Wu J, Wu GY and Zern MA: The prospects of hepatic drug delivery and gene therapy. Expert Opin Investig Drugs. 7:1795–1817. 1998. View Article : Google Scholar | |
|
Golubovic A, Tsai S and Li B: Bioinspired lipid nanocarriers for RNA delivery. ACS Bio Med Chem Au. 3:114–136. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Xu F, Reiser M, Yu X, Gummuluru S, Wetzler L and Reinhard BM: Lipid-mediated targeting with membrane-wrapped nanoparticles in the presence of corona formation. ACS Nano. 10:1189–1200. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Streeter SS, Hebert KA, Bateman LM, Ray GS, Dean RE, Geffken KT, Resnick CT, Austin DC, Bell JE, Sparks MB, et al: Current and future applications of fluorescence guidance in orthopaedic surgery. Mol Imaging Biol. 25:46–57. 2023. View Article : Google Scholar : | |
|
Brillante S, Volpe M and Indrieri A: Advances in MicroRNA therapeutics: From preclinical to clinical studies. Hum Gene Ther. 35:628–648. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Miao Y, Fu C, Yu Z, Yu L, Tang Y and Wei M: Current status and trends in small nucleic acid drug development: Leading the future. Acta Pharm Sin B. 14:3802–3817. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Nappi F: Non-coding RNA-targeted therapy: A state-of-the-Art review. Int J Mol Sci. 25:36302024. View Article : Google Scholar : PubMed/NCBI | |
|
Vermeire S, Nitcheu J, Gineste P, Flatres A, Santo J, Scherrer D, Peyrin-Biroulet L, Dulai PS, Danese S, Dubinsky M, et al: Obefazimod in patients with moderate-to-severely active ulcerative colitis: Efficacy and safety analysis from the 96-week open-label maintenance phase 2b study. J Crohns Colitis. 19:jjaf0742025. View Article : Google Scholar : PubMed/NCBI | |
|
Bauersachs J, Solomon SD, Anker SD, Antorrena-Miranda I, Batkai S, Viereck J, Rump S, Filippatos G, Granzer U, Ponikowski P, et al: Efficacy and safety of CDR132L in patients with reduced left ventricular ejection fraction after myocardial infarction: Rationale and design of the HF-REVERT trial. Eur J Heart Fail. 26:674–682. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Janssen HL, Reesink HW, Lawitz EJ, Zeuzem S, Rodriguez-Torres M, Patel K, van der Meer AJ, Patick AK, Chen A, Zhou Y, et al: Treatment of HCV infection by targeting microRNA. N Engl J Med. 368:1685–1694. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Hong DS, Kang YK, Borad M, Sachdev J, Ejadi S, Lim HY, Brenner AJ, Park K, Lee JL, Kim TY, et al: Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours. Br J Cancer. 122:1630–1637. 2020. View Article : Google Scholar : PubMed/NCBI |