[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Meng,Fanlan; Li,Jun; Yang,Xiao; Yuan,Xiaoyong; Tang,Xin

doi:10.3892/ijmm.2026.5748

April-2026 Volume 57 Issue 4

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Correction Open Access

[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Authors:
- Fanlan Meng
- Jun Li
- Xiao Yang
- Xiaoyong Yuan
- Xin Tang
View Affiliations / Copyright

Affiliations: Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, P.R. China, The State Key Laboratory of Proteomics, Genetics Laboratory of Development and Disease, Institute of Biotechnology, AMMS, Beijing 100071, P.R. China

Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 77
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Published online on: January 29, 2026

https://doi.org/10.3892/ijmm.2026.5748
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Int J Mol Med 42: [Related article:] 851-860, 2018; DOI: 10.3892/ijmm.2018.3662

Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that, concerning the immunofluorescence images shown in Fig. 2C on p. 855, the 'Blank/E-cadherin' and 'TGF-β2-SIS3/E-cadherin' data panels appeared to show the same data, albeit with different intensities of staining. In addition, in Fig. 3B on p. 856, the GAPDH blots shown for the '7 days' and '28 days' experiment gels were strikingly similar in appearance, in spite of different experiments being reported.

Figure 2

TGF-β/Smad3 pathway involved in EMT to HLE-B3 cells challenged with TGF-β2 (10 ng/ml). (A) Gene expression of EMT biomarkers inhibited by SIS3 in HLE-B3 cells. (B) Protein expression of EMT markers in HLE-B3 cells challenged with TGF-β2 (10 ng/ml) following treatment with Smad3 inhibitor SIS3. Scale bar=100 μm. *P<0.05 TGF-β2 + SIS3 group vs. the corresponding TGF-β2 group. TGF-β, transforming growth factor-β; Smad3, mothers against decapentaplegic 3; EMT, epithelial-mesenchymal transition; α-SMA, α-smooth muscle actin; FN1, fibronectin 1; COL1A1, collagen type 1 α1; CDH1, E-cadherin.

Figure 3

Expression levels of extracellular matrix components at different time points following anterior capsule injury. (A) mRNA expression levels of (a) lumican, (b) oesteopontin, (c) fibronectin, (d) collagen type I and (e-g) HAS in lens epithelial cells following anterior capsule injury. In situ protein expression levels were determined. (B) Western blot and (C) immunofluorescence of lumican; (D) immunofluorescence and (E) western blot of osteopontin; (F) western blot and (G) immunofluorescence of fibronectin. Immunofluorescence of (H) collagen type I and (I) HA in lens epithelial cells following injury. Scale bar=50 or 100 μm. *P<0.05, **P<0.01, ***P<0.001. KO, knockout; WT, wild-type; Smad3, mothers against decapentaplegic 3; HAS, hyaluronan synthase; HA, hyaluronan.

After having asked the authors to explain the apparent anomalies in these figures, they realized that they had been assembled erroneously. Corrected versions of Figs. 2 and 3, now showing the correct data for the 'TGF-β2-SIS3/E-cadherin' experiment in Fig. 2C and the GAPDH western blots for the '28 days' experiment in Fig. 3B, are shown opposite and on the next page. The errors made in assembling Figs. 2 and 3 did not grossly affect either the results or the conclusions reported in this paper. All the authors agree with the publication of this corrigendum, and are grateful to the Editor of International Journal of Molecular Medicine for allowing them the opportunity to present this; moreover, the Editor and the authors apologize to the readership for any inconvenience caused.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

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