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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April-2026 Volume 57 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Review Open Access

Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)

  • Authors:
    • Wei Li
    • Wen-Hong Wang
    • Yi Song
    • Xu-Jiong Li
    • Yan Li
    • Xia Wang
    • Ting-Ting Tian
    • Xiao Huang
    • Li Zhao

  • View Affiliations / Copyright

    Affiliations: Department of Exercise Physiology, Beijing Sport University, Beijing 100084, P.R. China, Key Laboratory of Bone Biomaterials and Dong Medicine‑Regulated Organoid Regeneration of Hunan Provincial Universities, Biomedical Research Institute, Hunan University of Medicine, Huaihua, Hunan 418000, P.R. China, Department of Neurosurgery, Chongqing University Three Gorges Hospital, Chongqing 404100, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 84
    |
    Published online on: February 4, 2026
       https://doi.org/10.3892/ijmm.2026.5755
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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder marked by progressive cognitive decline and whose pathology is closely linked to cellular autophagy dysfunction. Autophagy is a key process involved in cell clearance. Impaired autophagy can drive neuronal damage and death related to AD pathology. Therefore, targeting autophagy dysfunction has emerged as a promising therapeutic strategy. Exercise, as a non‑pharmaceutical and low‑cost intervention method, can enhance autophagy activity and alleviate AD symptoms. However, the mechanism by which it regulates autophagy in AD remains unclear. The present review summarizes evidence that exercise acts as an effective early intervention. Exercise activates key cellular signaling pathways (mammalian target of rapamycin, sirtuin 1 and adiponectin receptor 1) and regulates microRNAs (small non‑coding RNAs) and irisin (a muscle hormone) to restore normal autophagy. The present review also explores the use of exercise combined with natural products for potential synergistic therapeutic effects. This review provides insights into developing new AD prevention and management strategies by detailing how exercise corrects AD‑related autophagy dysfunction.

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Copy and paste a formatted citation
Spandidos Publications style
Li W, Wang W, Song Y, Li X, Li Y, Wang X, Tian T, Huang X and Zhao L: <p>Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)</p>. Int J Mol Med 57: 84, 2026.
APA
Li, W., Wang, W., Song, Y., Li, X., Li, Y., Wang, X. ... Zhao, L. (2026). <p>Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)</p>. International Journal of Molecular Medicine, 57, 84. https://doi.org/10.3892/ijmm.2026.5755
MLA
Li, W., Wang, W., Song, Y., Li, X., Li, Y., Wang, X., Tian, T., Huang, X., Zhao, L."<p>Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)</p>". International Journal of Molecular Medicine 57.4 (2026): 84.
Chicago
Li, W., Wang, W., Song, Y., Li, X., Li, Y., Wang, X., Tian, T., Huang, X., Zhao, L."<p>Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)</p>". International Journal of Molecular Medicine 57, no. 4 (2026): 84. https://doi.org/10.3892/ijmm.2026.5755
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Wang W, Song Y, Li X, Li Y, Wang X, Tian T, Huang X and Zhao L: <p>Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)</p>. Int J Mol Med 57: 84, 2026.
APA
Li, W., Wang, W., Song, Y., Li, X., Li, Y., Wang, X. ... Zhao, L. (2026). <p>Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)</p>. International Journal of Molecular Medicine, 57, 84. https://doi.org/10.3892/ijmm.2026.5755
MLA
Li, W., Wang, W., Song, Y., Li, X., Li, Y., Wang, X., Tian, T., Huang, X., Zhao, L."<p>Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)</p>". International Journal of Molecular Medicine 57.4 (2026): 84.
Chicago
Li, W., Wang, W., Song, Y., Li, X., Li, Y., Wang, X., Tian, T., Huang, X., Zhao, L."<p>Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)</p>". International Journal of Molecular Medicine 57, no. 4 (2026): 84. https://doi.org/10.3892/ijmm.2026.5755
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