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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April-2026 Volume 57 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Correction Open Access

[Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs

  • Authors:
    • Qing-Yong Chen
    • Li-Qun Xu
    • De-Min Jiao
    • Qing-Hua Yao
    • Yan-Yi Wang
    • Hui-Zhen Hu
    • Yu-Quan Wu
    • Jia Song
    • Jie Yan
    • Li-Jun Wu
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Disease, The 117th Hospital of PLA, Hang Zhou 310013, P.R. China, Department of Oncology Disease, The 117th Hospital of PLA, Hang Zhou 310013, P.R. China, Department of Respiratory Disease, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hang Zhou 310053, P.R. China, College of Life Science, Guizhou University, Guiyang 550025, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 94
    |
    Published online on: February 12, 2026
       https://doi.org/10.3892/ijmm.2026.5765
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Article

View Figures

Figure 1

Transwell insert and wound healing
assay showing that Rac1 regulates cell migration and invasion in
vitro. After initial equilibrium, 801D cells un-transfected or
transfected with Rac1 or negative control and treated with NSC23766
suspended in fresh medium without fetal bovine serum were added to
the insert. (A) The migratory cell number of 801D transfected with
Rac1 was significantly less than that of 801D cells transfected
with negative control or un-transfected. (B) Confluent cell
monolayers were wounded with a pipette tip. Wound closure was
monitored by microscopy at the indicated times. (C) For the
invasion assay, the inserts were coated with ECM and then repeated
as for the migration assay. The invasive cell number of 801D
transfected with Rac1 was also significantly lower than that of
801D cells transfected with negative control. Effects of NSC23766
treatment on the invasion of lung cancer cells is very similar to
the effects of Rac1-shRNA. *P<0.05 compared with
control.

Figure 2

Expression of Rac1 in lung cancer
tissues and its relation to overall survival. (A) Negative
immunostaining for Rac1 in normal lung tissues. In contrast, Rac1
showed strong cytoplasmic staining in (B) lung adenocarcinoma and
(C) lung squamous cell carcinoma (SCC), weak cytoplasmic staining
in (D) lung adenocarcinoma and (E) lung SCC. (F) Kaplan-Meier
survival curves were constructed, and the difference between the
Rac1-positive and Rac1-negative groups was analyzed by log-rank
test. Magnification, ×200.

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Copy and paste a formatted citation
Spandidos Publications style
Chen Q, Xu L, Jiao D, Yao Q, Wang Y, Hu H, Wu Y, Song J, Yan J, Wu L, Wu L, et al: [Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs. Int J Mol Med 57: 94, 2026.
APA
Chen, Q., Xu, L., Jiao, D., Yao, Q., Wang, Y., Hu, H. ... Wu, L. (2026). [Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs. International Journal of Molecular Medicine, 57, 94. https://doi.org/10.3892/ijmm.2026.5765
MLA
Chen, Q., Xu, L., Jiao, D., Yao, Q., Wang, Y., Hu, H., Wu, Y., Song, J., Yan, J., Wu, L."[Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs". International Journal of Molecular Medicine 57.4 (2026): 94.
Chicago
Chen, Q., Xu, L., Jiao, D., Yao, Q., Wang, Y., Hu, H., Wu, Y., Song, J., Yan, J., Wu, L."[Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs". International Journal of Molecular Medicine 57, no. 4 (2026): 94. https://doi.org/10.3892/ijmm.2026.5765
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Q, Xu L, Jiao D, Yao Q, Wang Y, Hu H, Wu Y, Song J, Yan J, Wu L, Wu L, et al: [Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs. Int J Mol Med 57: 94, 2026.
APA
Chen, Q., Xu, L., Jiao, D., Yao, Q., Wang, Y., Hu, H. ... Wu, L. (2026). [Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs. International Journal of Molecular Medicine, 57, 94. https://doi.org/10.3892/ijmm.2026.5765
MLA
Chen, Q., Xu, L., Jiao, D., Yao, Q., Wang, Y., Hu, H., Wu, Y., Song, J., Yan, J., Wu, L."[Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs". International Journal of Molecular Medicine 57.4 (2026): 94.
Chicago
Chen, Q., Xu, L., Jiao, D., Yao, Q., Wang, Y., Hu, H., Wu, Y., Song, J., Yan, J., Wu, L."[Corrigendum] Silencing of Rac1 modifies lung cancer cell migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs". International Journal of Molecular Medicine 57, no. 4 (2026): 94. https://doi.org/10.3892/ijmm.2026.5765
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