Mechanism of action and clinical application of autophagy in multiple sclerosis (Review)

Wang,Dongmei; Fu,Qizhi; Zhao,Ying; Li,Guangda; Bai,Yongjie; Yang,Yang; Song,Hongna; Wang,Mingwei; Fan,Hua

doi:10.3892/ijmm.2026.5800

May-2026 Volume 57 Issue 5

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May-2026 Volume 57 Issue 5

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Review Open Access

Mechanism of action and clinical application of autophagy in multiple sclerosis (Review)

Authors:
- Dongmei Wang
- Qizhi Fu
- Ying Zhao
- Guangda Li
- Yongjie Bai
- Yang Yang
- Hongna Song
- Mingwei Wang
- Hua Fan
View Affiliations / Copyright

Affiliations: College of Basic Medicine and Forensic Medicine, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471000, P.R. China, Office of Research & Innovation, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471000, P.R. China, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, Henan 471000, P.R. China, Department of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, P.R. China, Department of Neuro‑auricular Vertigo, The Second Hospital Affiliated to Henan University of Science and Technology, Luoyang, Henan 471000, P.R. China, Department of Cardiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 311321, P.R. China

Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 129
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Published online on: March 17, 2026

https://doi.org/10.3892/ijmm.2026.5800
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Abstract

Multiple sclerosis (MS) is a progressive, long‑term disorder affecting the central nervous system. The management and treatment of MS require significant medical resources, placing a heavy burden on both individuals and society. Autophagy is essential for the degradation of dysfunctional or excess cellular components. In the context of MS, autophagy exhibits dual roles, both protective and detrimental. On one hand, it mitigates disease progression by reducing oxidative stress and inflammation. On the other hand, autophagy activates various immune and supportive cells pivotal in MS pathogenesis. This review aims to explore the relationship between autophagy and MS, its impact on disease progression and the current challenges in this field.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Mechanism of action and clinical application of autophagy in multiple sclerosis (Review)

This article is mentioned in:

Abstract

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