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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June-2026 Volume 57 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Review Open Access

ETS‑1/ETS‑2 transcription factors in CVD (Review)

  • Authors:
    • Shasha Yang
    • Jing Zhang
    • Ying Yang
    • Yunbo Lv
    • Jian Yang
    • Huibo Wang

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443002, P.R. China, Institute of Cardiovascular Diseases, China Three Gorges University, Yichang, Hubei 443002, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 157
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    Published online on: April 15, 2026
       https://doi.org/10.3892/ijmm.2026.5828
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Abstract

Cardiovascular diseases remain the leading cause of global morbidity and mortality, imposing a significant burden on families and societies. E26 transformation‑specific (ETS)‑1 and ETS‑2, members of the ETS family of transcription factors (also known as proto‑oncogenes), are increasingly recognized for their roles in tumor progression. Recent studies highlight their importance in normal coronary artery development, myocardial homeostasis and the regulation of vascular inflammation and remodeling. Emerging evidence suggests that ETS‑1/ETS‑2 are critical in the pathogenesis of atherosclerosis, myocardial ischemia‑reperfusion injury, cardiac remodeling and heart failure. The present review summarized the research progress of ETS‑1/ETS‑2 in cardiovascular diseases, discusses the relevant challenges encountered in the translational process of ETS‑1/ETS‑2‑targeted therapy for cardiovascular diseases and provides novel strategies for the treatment of cardiovascular diseases targeting ETS‑1/ETS‑2.

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Copy and paste a formatted citation
Spandidos Publications style
Yang S, Zhang J, Yang Y, Lv Y, Yang J and Wang H: ETS‑1/ETS‑2 transcription factors in CVD (Review). Int J Mol Med 57: 157, 2026.
APA
Yang, S., Zhang, J., Yang, Y., Lv, Y., Yang, J., & Wang, H. (2026). ETS‑1/ETS‑2 transcription factors in CVD (Review). International Journal of Molecular Medicine, 57, 157. https://doi.org/10.3892/ijmm.2026.5828
MLA
Yang, S., Zhang, J., Yang, Y., Lv, Y., Yang, J., Wang, H."ETS‑1/ETS‑2 transcription factors in CVD (Review)". International Journal of Molecular Medicine 57.6 (2026): 157.
Chicago
Yang, S., Zhang, J., Yang, Y., Lv, Y., Yang, J., Wang, H."ETS‑1/ETS‑2 transcription factors in CVD (Review)". International Journal of Molecular Medicine 57, no. 6 (2026): 157. https://doi.org/10.3892/ijmm.2026.5828
Copy and paste a formatted citation
x
Spandidos Publications style
Yang S, Zhang J, Yang Y, Lv Y, Yang J and Wang H: ETS‑1/ETS‑2 transcription factors in CVD (Review). Int J Mol Med 57: 157, 2026.
APA
Yang, S., Zhang, J., Yang, Y., Lv, Y., Yang, J., & Wang, H. (2026). ETS‑1/ETS‑2 transcription factors in CVD (Review). International Journal of Molecular Medicine, 57, 157. https://doi.org/10.3892/ijmm.2026.5828
MLA
Yang, S., Zhang, J., Yang, Y., Lv, Y., Yang, J., Wang, H."ETS‑1/ETS‑2 transcription factors in CVD (Review)". International Journal of Molecular Medicine 57.6 (2026): 157.
Chicago
Yang, S., Zhang, J., Yang, Y., Lv, Y., Yang, J., Wang, H."ETS‑1/ETS‑2 transcription factors in CVD (Review)". International Journal of Molecular Medicine 57, no. 6 (2026): 157. https://doi.org/10.3892/ijmm.2026.5828
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