|
1
|
Ostermann M, Lumlertgul N, Jeong R, See E,
Joannidis M and James M: Acute kidney injury. Lancet. 405:241–256.
2025. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Levey AS and James MT: Acute kidney
injury. Ann Intern Med. 167:ITC66–ITC80. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Bellomo R, Kellum JA and Ronco C: Acute
kidney injury. Lancet. 380:756–766. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Gao J, Deng Q, Yu J, Wang C and Wei W:
Role of renal tubular epithelial cells and macrophages in
cisplatin-induced acute renal injury. Life Sci. 339:1224502024.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Li ZL, Li XY, Zhou Y, Wang B, Lv LL and
Liu BC: Renal tubular epithelial cells response to injury in acute
kidney injury. EBioMedicine. 107:1052942024. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Martin-Sanchez D, Ruiz-Andres O, Poveda J,
Carrasco S, Cannata-Ortiz P, Sanchez-Niño MD, Ruiz Ortega M, Egido
J, Linkermann A, Ortiz A and Sanz AB: Ferroptosis, but not
necroptosis, is important in nephrotoxic folic acid-induced AKI. J
Am Soc Nephrol. 28:218–229. 2017. View Article : Google Scholar
|
|
7
|
Guo R, Duan J, Pan S, Cheng F, Qiao Y,
Feng Q, Liu D and Liu Z: The road from AKI to CKD: Molecular
mechanisms and therapeutic targets of ferroptosis. Cell Death Dis.
14:4262023. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Zhao Z, Wu J, Xu H, Zhou C, Han B, Zhu H,
Hu Z, Ma Z, Ming Z, Yao Y, et al: XJB-5-131 inhibited ferroptosis
in tubular epithelial cells after ischemia-reperfusion injury. Cell
Death Dis. 11:6292020. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Dodson M, Castro-Portuguez R and Zhang DD:
NRF2 plays a critical role in mitigating lipid peroxidation and
ferroptosis. Redox Biol. 23:1011072019. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
He L, Chen Q, Wang L, Pu Y, Huang J, Cheng
CK, Luo JY, Kang L, Lin X, Xiang L, et al: Activation of Nrf2
inhibits atherosclerosis in ApoE−/− mice through
suppressing endothelial cell inflammation and lipid peroxidation.
Redox Biol. 74:1032292024. View Article : Google Scholar
|
|
11
|
Ma F, Luo S, Lu C, Jiang X, Chen K, Deng
J, Ma S and Li Z: The role of Nrf2 in periodontal disease by
regulating lipid peroxidation, inflammation and apoptosis. Front
Endocrinol (Lausanne). 13:9634512022. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Li Y, Huang J, Wang J, Xia S, Ran H, Gao
L, Feng C, Gui L, Zhou Z and Yuan J: Human umbilical cord-derived
mesenchymal stem cell transplantation supplemented with curcumin
improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2
axis. J Neuroinflammation. 20:492023. View Article : Google Scholar
|
|
13
|
Cai F, Li D, Zhou K, Zhang W and Yang Y:
Tiliroside attenuates acute kidney injury by inhibiting ferroptosis
through the disruption of NRF2-KEAP1 interaction. Phytomedicine.
126:1554072024. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Shi Z, Zhang Y, Wang X, Tang J, Kang Y, Hu
J, Li L, Yang B, Chen S, Xiao Q, et al: Discovery of propionic acid
derivatives with a 5-THIQ core as potent and orally bioavailable
keap1-Nrf2 protein-protein interaction inhibitors for acute kidney
injury. J Med Chem. 67:19247–19266. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Zhang JL, Du C, Poon CCW, He MC, Wong MS,
Wang NN and Zhang Y: Structural characterization and protective
effect against renal fibrosis of polysaccharide from Ligustrum
lucidum Ait. J Ethnopharmacol. 302:1158982023. View Article : Google Scholar
|
|
16
|
Wang YS, Jin YX, Liu KJ, Guo C, Wang YH,
Xu C, Zhang ZX and Dong WP: Species identification of Ligustrum
lucidum. Zhongguo Zhong Yao Za Zhi. 48:2940–2948. 2023.In Chinese.
PubMed/NCBI
|
|
17
|
Zhang YY, Liu WN, Li YQ, Zhang XJ, Yang J,
Luo XJ and Peng J: Ligustroflavone reduces necroptosis in rat brain
after ischemic stroke through targeting RIPK1/RIPK3/MLKL pathway.
Naunyn Schmiedebergs Arch Pharmacol. 392:1085–1095. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Kang R, Tian W, Cao W, Sun Y, Zhang HN,
Feng YD, Li C, Li ZZ and Li XQ: Ligustroflavone ameliorates
CCl4-induced liver fibrosis through down-regulating the
TGF-β/Smad signaling pathway. Chin J Nat Med. 19:170–180.
2021.PubMed/NCBI
|
|
19
|
Feng R, Ding F, Mi XH, Liu SF, Jiang AL,
Liu BH, Lian Y, Shi Q, Wang YJ and Zhang Y: Protective effects of
ligustroflavone, an active compound from Ligustrum lucidum, on
diabetes-induced osteoporosis in mice: A potential candidate as
calcium-sensing receptor antagonist. Am J Chin Med. 47:457–476.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Bi F, Bai Y, Zhang Y and Liu W:
Ligustroflavone exerts neuroprotective activity through suppression
of NLRP1 inflammasome in ischaemic stroke mice. Exp Ther Med.
25:82022. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Pieroni A and Pachaly P: Isolation and
structure elucidation of ligustroflavone, a new apigenin
triglycoside from the leaves of Ligustrum vulgare L. Pharmazie.
55:78–80. 2000.PubMed/NCBI
|
|
22
|
MacArthur Clark JA and Sun D: Guidelines
for the ethical review of laboratory animal welfare People's
Republic of China national standard GB/T 35892-2018 [Issued 6
February 2018 Effective from 1 September 2018]. Animal Model Exp
Med. 3:103–113. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Yang Y, Cai F, Zhou N, Liu S, Wang P,
Zhang S, Zhang Y, Zhang A, Jia Z and Huang S: Dimethyl fumarate
prevents ferroptosis to attenuate acute kidney injury by acting on
NRF2. Clin Transl Med. 11:e3822021. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Song J, Sheng J, Lei J, Gan W and Yang Y:
Mitochondrial targeted antioxidant SKQ1 ameliorates acute kidney
injury by inhibiting ferroptosis. Oxid Med Cell Longev.
2022:22239572022. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
26
|
Zilka O, Shah R, Li B, Friedmann Angeli
JP, Griesser M, Conrad M and Pratt DA: On the mechanism of
cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of
lipid peroxidation in ferroptotic cell death. ACS Cent Sci.
3:232–243. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Martinez Molina D, Jafari R,
Ignatushchenko M, Seki T, Larsson EA, Dan C, Sreekumar L, Cao Y and
Nordlund P: Monitoring drug target engagement in cells and tissues
using the cellular thermal shift assay. Science. 341:84–87. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Bogen SA, Dabbs DJ, Miller KD, Nielsen S,
Parry SC, Szabolcs MJ, t'Hart N, Taylor CR and Torlakovic EE: A
consortium for analytic standardization in immunohistochemistry.
Arch Pathol Lab Med. 147:584–590. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Trott O and Olson AJ: AutoDock Vina:
Improving the speed and accuracy of docking with a new scoring
function, efficient optimization, and multithreading. J Comput
Chem. 31:455–461. 2010. View Article : Google Scholar
|
|
30
|
Zhang L, Chen F, Dong J, Wang R, Bi G, Xu
D, Zhang Y, Deng Y, Lin W, Yang Z and Cao W: HDAC3
aberration-incurred GPX4 suppression drives renal ferroptosis and
AKI-CKD progression. Redox Biol. 68:1029392023. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wang Y, Zhang M, Bi R, Su Y, Quan F, Lin
Y, Yue C, Cui X, Zhao Q, Liu S, et al: ACSL4 deficiency confers
protection against ferroptosis-mediated acute kidney injury. Redox
Biol. 51:1022622022. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Ranea-Robles P, Launay N, Ruiz M,
Calingasan NY, Dumont M, Naudí A, Portero-Otín M, Pamplona R,
Ferrer I, Beal MF, et al: Aberrant regulation of the GSK-3β/NRF2
axis unveils a novel therapy for adrenoleukodystrophy. EMBO Mol
Med. 10:e86042018. View Article : Google Scholar
|
|
33
|
Jamadar A and Rao R: Glycogen synthase
kinase-3 signaling in acute kidney injury. Nephron. 144:609–612.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Sohaney R, Yin H, Shahinian V, Saran R,
Burrows NR, Pavkov ME, Banerjee T, Hsu CY, Powe N, Steffick D, et
al: In-hospital and 1-year mortality trends in a national cohort of
US veterans with acute kidney injury. Clin J Am Soc Nephrol.
17:184–193. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Coca SG, Singanamala S and Parikh CR:
Chronic kidney disease after acute kidney injury: A systematic
review and meta-analysis. Kidney Int. 81:442–448. 2012. View Article : Google Scholar
|
|
36
|
Turgut F, Awad AS and Abdel-Rahman EM:
Acute kidney injury: Medical causes and pathogenesis. J Clin Med.
12:3752023. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Sanz AB, Sanchez-Niño MD, Ramos AM and
Ortiz A: Regulated cell death pathways in kidney disease. Nat Rev
Nephrol. 19:281–299. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Tonnus W, Meyer C, Steinebach C, Belavgeni
A, von Mässenhausen A, Gonzalez NZ, Maremonti F, Gembardt F,
Himmerkus N, Latk M, et al: Dysfunction of the key
ferroptosis-surveilling systems hypersensitizes mice to tubular
necrosis during acute kidney injury. Nat Commun. 12:44022021.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Chen GL, Fan MX, Wu JL, Li N and Guo MQ:
Antioxidant and anti-inflammatory properties of flavonoids from
lotus plumule. Food Chem. 277:706–712. 2019. View Article : Google Scholar
|
|
40
|
Feng YD, Ye W, Tian W, Meng JR, Zhang M,
Sun Y, Zhang HN, Wang SJ, Wu KH, Liu CX, et al: Old targets, new
strategy: Apige nin-7-O-β-d-(-6''-p-coumaroyl)-glucopyranoside
prevents endothelial ferroptosis and alleviates intestinal
ischemia-reperfusion injury through HO-1 and MAO-B inhibition. Free
Radic Biol Med. 184:74–88. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Han XH, Hong SS, Hwang JS, Lee MK, Hwang
BY and Ro JS: Monoamine oxidase inhibitory components from Cayratia
japonica. Arch Pharm Res. 30:13–17. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Jang DS, Lee YM, Jeong IH and Kim JS:
Constituents of the flowers of Platycodon grandiflorum with
inhibitory activity on advanced glycation end products and rat lens
aldose reductase in vitro. Arch Pharm Res. 33:875–880. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Wang X, Chen T, Chen S, Zhang J, Cai L,
Liu C, Zhang Y, Wu X, Li N, Ma Z, et al: STING aggravates
ferroptosis-dependent myocardial ischemia-reperfusion injury by
targeting GPX4 for autophagic degradation. Signal Transduct Target
Ther. 10:1362025. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Jiang X, Stockwell BR and Conrad M:
Ferroptosis: Mechanisms, biology and role in disease. Nat Rev Mol
Cell Biol. 22:266–282. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Zeng Y, Xiong L, Tang H, Chen L, Yu Q, Li
L, Chen F, Li L, Zheng Y, Sun J, et al: Norboldine improves
cognitive impairment and pathological features in Alzheimer's
disease by activating AMPK/GSK3β/Nrf2 signaling pathway. J
Ethnopharmacol. 333:1184982024. View Article : Google Scholar
|
|
46
|
Song M, Zhang S, Yu W and Fan X: Gomisin N
rescues cognitive impairment of Alzheimer's disease by targeting
GSK3β and activating Nrf2 signaling pathway. Phytomedicine.
132:1558112024. View Article : Google Scholar
|
|
47
|
Lu C, Xu C, Li S, Ni H and Yang J:
Liraglutide and GLP-1(9-37) alleviated hepatic ischemia-reperfusion
injury by inhibiting ferroptosis via GSK3β/Nrf2 pathway and
SMAD159/Hepcidin/FTH pathway. Redox Biol. 79:1034682025. View Article : Google Scholar
|
|
48
|
Fan G, Huang L, Wang M, Kuang H, Li Y and
Yang X: GPAT3 deficiency attenuates corticosterone-caused hepatic
steatosis and oxidative stress through GSK3β/Nrf2 signals. Biochim
Biophys Acta Mol Basis Dis. 1870:1670072024. View Article : Google Scholar
|
|
49
|
Lv M, Cai Y, Hou W, Peng K, Xu K, Lu C, Yu
W, Zhang W and Liu L: The C5AR1/TNFSF13B axis alleviates
osteoarthritis by activating the PI3K/Akt/GSK3β/Nrf2/HO-1 pathway
to inhibit ferroptosis. Exp Cell Res. 441:1141952024. View Article : Google Scholar
|
|
50
|
Chen P, Huo X, Liu W, Li K, Sun Z and Tian
J: Apigenin exhibits anti-inflammatory effects in LPS-stimulated
BV2 microglia through activating GSK3β/Nrf2 signaling pathway.
Immunopharmacol Immunotoxicol. 42:9–16. 2020. View Article : Google Scholar
|
|
51
|
Wang L, Ouyang S, Li B, Wu H and Wang F:
GSK-3β manipulates ferroptosis sensitivity by dominating iron
homeostasis. Cell Death Discov. 7:3342021. View Article : Google Scholar
|
|
52
|
Feng X, Guan W, Zhao Y, Wang C, Song M,
Yao Y, Yang T and Fan H: Dexmedetomidine ameliorates
lipopolysaccharide-induced acute kidney injury in rats by
inhibiting inflammation and oxidative stress via the GSK-3β/Nrf2
signaling pathway. J Cell Physiol. 234:18994–19009. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Cai YT, Li Z, Wang YY, Li C and Ma QY: A
novel GSK3β inhibitor 5n attenuates acute kidney injury. Heliyon.
10:e291592024. View Article : Google Scholar
|
|
54
|
Lu M, Wang P, Qiao Y, Jiang C, Ge Y,
Flickinger B, Malhotra DK, Dworkin LD, Liu Z and Gong R:
GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant
response: A molecular rheostat of acute kidney injury to chronic
kidney disease transition. Redox Biol. 26:1012752019. View Article : Google Scholar
|