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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July-2026 Volume 58 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Review Open Access

Rab27: Molecular switch of tumor exosome secretion (Review)

  • Authors:
    • Mengtian Tang
    • Zhongjian Zhu
    • Huaxin Duan
    • Shiming Tan
    • Mengzhou Shen
    • Xianjie Jiang
    • Qiu Peng
    • Linda Oyang
    • Zongyao Ren
    • Yujuan Zhou
    • Qianjin Liao

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Hunan Normal University Health Science Center, Changsha, Hunan 410005, P.R. China, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer Metabolism, Changsha, Hunan 410013, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 182
    |
    Published online on: May 12, 2026
       https://doi.org/10.3892/ijmm.2026.5853
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Abstract

Rab proteins are core regulators of vesicle trafficking during membrane transport. As key members of this family, Rab27 comprises two functionally distinct isoforms, Rab27a and Rab27b, and participates in the regulation of exosome secretion by mediating the selective anchoring of multivesicular bodies to the plasma membrane. In tumor cells, Rab27 promotes malignant progression by modulating exosome secretion. Aberrantly expressed Rab27 is associated with the prognosis of patients with cancer, suggesting its potential as a prognostic biomarker for various malignant tumors. Furthermore, the development of novel small‑molecule drugs targeting Rab27 is promising because these drugs can exert antitumor effects through interference with the exosome secretory pathway. The present review systematically summarizes the molecular mechanisms underlying the Rab27‑mediated regulation of exosome secretion and its role in tumorigenesis and cancer progression and discusses the application prospects and challenges of Rab27‑targeted antitumor therapeutic strategies, aiming to provide a reference for basic research and clinical translation of Rab27.

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Copy and paste a formatted citation
Spandidos Publications style
Tang M, Zhu Z, Duan H, Tan S, Shen M, Jiang X, Peng Q, Oyang L, Ren Z, Zhou Y, Zhou Y, et al: Rab27: Molecular switch of tumor exosome secretion (Review). Int J Mol Med 58: 182, 2026.
APA
Tang, M., Zhu, Z., Duan, H., Tan, S., Shen, M., Jiang, X. ... Liao, Q. (2026). Rab27: Molecular switch of tumor exosome secretion (Review). International Journal of Molecular Medicine, 58, 182. https://doi.org/10.3892/ijmm.2026.5853
MLA
Tang, M., Zhu, Z., Duan, H., Tan, S., Shen, M., Jiang, X., Peng, Q., Oyang, L., Ren, Z., Zhou, Y., Liao, Q."Rab27: Molecular switch of tumor exosome secretion (Review)". International Journal of Molecular Medicine 58.1 (2026): 182.
Chicago
Tang, M., Zhu, Z., Duan, H., Tan, S., Shen, M., Jiang, X., Peng, Q., Oyang, L., Ren, Z., Zhou, Y., Liao, Q."Rab27: Molecular switch of tumor exosome secretion (Review)". International Journal of Molecular Medicine 58, no. 1 (2026): 182. https://doi.org/10.3892/ijmm.2026.5853
Copy and paste a formatted citation
x
Spandidos Publications style
Tang M, Zhu Z, Duan H, Tan S, Shen M, Jiang X, Peng Q, Oyang L, Ren Z, Zhou Y, Zhou Y, et al: Rab27: Molecular switch of tumor exosome secretion (Review). Int J Mol Med 58: 182, 2026.
APA
Tang, M., Zhu, Z., Duan, H., Tan, S., Shen, M., Jiang, X. ... Liao, Q. (2026). Rab27: Molecular switch of tumor exosome secretion (Review). International Journal of Molecular Medicine, 58, 182. https://doi.org/10.3892/ijmm.2026.5853
MLA
Tang, M., Zhu, Z., Duan, H., Tan, S., Shen, M., Jiang, X., Peng, Q., Oyang, L., Ren, Z., Zhou, Y., Liao, Q."Rab27: Molecular switch of tumor exosome secretion (Review)". International Journal of Molecular Medicine 58.1 (2026): 182.
Chicago
Tang, M., Zhu, Z., Duan, H., Tan, S., Shen, M., Jiang, X., Peng, Q., Oyang, L., Ren, Z., Zhou, Y., Liao, Q."Rab27: Molecular switch of tumor exosome secretion (Review)". International Journal of Molecular Medicine 58, no. 1 (2026): 182. https://doi.org/10.3892/ijmm.2026.5853
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