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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August-2026 Volume 58 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

  • Authors:
    • Zhibo Fan
    • Qiyue Fu
    • Tao Sun
    • Yutong Zhong
    • Yuefan Ma
    • Jingwei Jian
    • Shuosheng Yuan
    • Shenghong Li
    • Xiaomei Xu

  • View Affiliations / Copyright

    Affiliations: Department of Orthodontics, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
    Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 207
    |
    Published online on: June 2, 2026
       https://doi.org/10.3892/ijmm.2026.5878
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Abstract

Osteoarthritis (OA), characterized by articular cartilage degeneration and subchondral bone remodeling, is a notable cause of disability globally. The present study aimed to explore the role and mechanism of histone H3 lysine 18 lactylation (H3K18la) in OA osteoclast differentiation and verify the therapeutic potential of targeting this pathway. Using a mouse OA model (anterior cruciate ligament transection), RAW264.7 cell experiments, oxmacid‑mediated lactate inhibition and cleavage under targets and tagmentation to map genomic targets, the present study demonstrated elevated H3K18la in OA joint osteoclasts, associated with reduced bone mineral density and aggravated subchondral bone destruction. Analysis of TRAP and lactate indicated that RANKL‑induced osteoclast differentiation increased lactate production, enhancing H3K18la; oxmacid inhibited both of these processes. H3K18la was enriched at the acid phosphatase 5 promoter and directly promoted its transcription. Local oxmacid injection in OA mice decreased osteoclast numbers and alleviated subchondral bone loss. Thus, H3K18la was a key metabolic‑epigenetic mediator linking glycolysis to osteoclast differentiation, representing a novel OA therapeutic target.

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Copy and paste a formatted citation
Spandidos Publications style
Fan Z, Fu Q, Sun T, Zhong Y, Ma Y, Jian J, Yuan S, Li S and Xu X: Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis. Int J Mol Med 58: 207, 2026.
APA
Fan, Z., Fu, Q., Sun, T., Zhong, Y., Ma, Y., Jian, J. ... Xu, X. (2026). Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis. International Journal of Molecular Medicine, 58, 207. https://doi.org/10.3892/ijmm.2026.5878
MLA
Fan, Z., Fu, Q., Sun, T., Zhong, Y., Ma, Y., Jian, J., Yuan, S., Li, S., Xu, X."Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis". International Journal of Molecular Medicine 58.2 (2026): 207.
Chicago
Fan, Z., Fu, Q., Sun, T., Zhong, Y., Ma, Y., Jian, J., Yuan, S., Li, S., Xu, X."Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis". International Journal of Molecular Medicine 58, no. 2 (2026): 207. https://doi.org/10.3892/ijmm.2026.5878
Copy and paste a formatted citation
x
Spandidos Publications style
Fan Z, Fu Q, Sun T, Zhong Y, Ma Y, Jian J, Yuan S, Li S and Xu X: Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis. Int J Mol Med 58: 207, 2026.
APA
Fan, Z., Fu, Q., Sun, T., Zhong, Y., Ma, Y., Jian, J. ... Xu, X. (2026). Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis. International Journal of Molecular Medicine, 58, 207. https://doi.org/10.3892/ijmm.2026.5878
MLA
Fan, Z., Fu, Q., Sun, T., Zhong, Y., Ma, Y., Jian, J., Yuan, S., Li, S., Xu, X."Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis". International Journal of Molecular Medicine 58.2 (2026): 207.
Chicago
Fan, Z., Fu, Q., Sun, T., Zhong, Y., Ma, Y., Jian, J., Yuan, S., Li, S., Xu, X."Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis". International Journal of Molecular Medicine 58, no. 2 (2026): 207. https://doi.org/10.3892/ijmm.2026.5878
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