|
1
|
Zhen G, Wen C, Jia X, Li Y, Crane JL,
Mears SC, Askin FB, Frassica FJ, Chang W, Yao J, et al: Inhibition
of TGF-β signaling in mesenchymal stem cells of subchondral bone
attenuates osteoarthritis. Nat Med. 19:704–712. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Qiu L, Alhaskawi A and Moqbel SAA:
Osteoarthritis: Multitissue pathology, molecular mechanisms,
clinical management, and emerging precision and regenerative
therapies. Front Pharmacol. 16:16971922026. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Jiang W, Jin Y, Zhang S, Ding Y, Huo K,
Yang J, Zhao L, Nian B, Zhong TP, Lu W, et al: PGE2 activates EP4
in subchondral bone osteoclasts to regulate osteoarthritis. Bone
Res. 10:272022. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Ledesma-Colunga MG, Passin V, Lademann F,
Hofbauer LC and Rauner M: Novel insights into osteoclast energy
metabolism. Curr Osteoporos Rep. 21:660–669. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Zhu S, Zhu J, Zhen G, Hu Y, An S, Li Y,
Zheng Q, Chen Z, Yang Y, Wan M, et al: Subchondral bone osteoclasts
induce sensory innervation and osteoarthritis pain. J Clin
Investigat. 129:1076–1093. 2019. View Article : Google Scholar
|
|
6
|
Takegahara N, Kim H and Choi Y: Unraveling
the intricacies of osteoclast differentiation and maturation:
Insight into novel therapeutic strategies for bone-destructive
diseases. Exp Mol Med. 56:264–272. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Zhang D, Tang Z, Huang H, Zhou G, Cui C,
Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, et al: Metabolic
regulation of gene expression by histone lactylation. Nature.
574:575–580. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Park-Min KH: Metabolic reprogramming in
osteoclasts. Semin Immunopathol. 41:565–572. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Karner CM and Long F: Glucose metabolism
in bone. Bone. 115:2–7. 2018. View Article : Google Scholar :
|
|
10
|
Xin Q, Wang H, Li Q, Liu S, Qu K, Liu C
and Zhang J: Lactylation: A passing fad or the future of
posttranslational modification. Inflammation. 45:1419–1429. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Zhang D, Gao J, Zhu Z, Mao Q, Xu Z, Singh
PK, Rimayi CC, Moreno-Yruela C, Xu S, Li G, et al: Lysine
l-lactylation is the dominant lactylation isomer induced by
glycolysis. Nat Chem Biol. 21:91–99. 2025. View Article : Google Scholar
|
|
12
|
Wang J, Yang P, Yu T, Gao M, Liu D, Zhang
J, Lu C, Chen X, Zhang X and Liu Y: Lactylation of PKM2 suppresses
inflammatory metabolic adaptation in Pro-inflammatory macrophages.
Int J Biol Sci. 18:6210–6225. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Du S, Zhang X, Jia Y, Peng P, Kong Q,
Jiang S, Li Y, Li C, Ding Z and Liu L: Hepatocyte HSPA12A inhibits
macrophage chemotaxis and activation to attenuate liver
ischemia/reperfusion injury via suppressing glycolysis-mediated
HMGB1 lactylation and secretion of hepatocytes. Theranostics.
13:3856–3871. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Zhang H, Wang L, Cui J, Wang S, Han Y,
Shao H, Wang C, Hu Y, Li X, Zhou Q, et al: Maintaining hypoxia
environment of subchondral bone alleviates osteoarthritis
progression. Sci Adv. 9:eabo78682023. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Lorenzo J: Sexual dimorphism in
osteoclasts. Cells. 9:20862020. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Percie Du Sert N, Ahluwalia A, Alam S,
Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U,
Emerson M, et al: Reporting animal research: Explanation and
elaboration for the ARRIVE guidelines 2.0. PLoS Biol.
18:e30004112020. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Yang J, Li W, Lin X and Liang W: A lactate
metabolism-related gene signature to diagnose osteoarthritis based
on machine learning combined with experimental validation. Aging
(Albany NY). 16:13076–13103. 2024.PubMed/NCBI
|
|
18
|
Xia J, Qiao Z, Hao X and Zhang Y:
LDHA-induced histone lactylation mediates the development of
osteoarthritis through regulating the transcription activity of
TPI1 gene. Autoimmunity. 57:23848892024. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
20
|
Huang YF, Wang G, Ding L, Bai ZR, Leng Y,
Tian JW, Zhang JZ, Li YQ, Ahmad, Qin YH, et al: Lactate-upregulated
NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes
to ROS-induced osteoarthritis chondrocyte damage. Redox Biology.
67:1028672023. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Wang J, Guan H, Liu H, Lei Z, Kang H, Guo
Q, Dong Y, Liu H, Sun Y, Fang Z and Li F: Inhibition of PFKFB3
suppresses osteoclastogenesis and prevents ovariectomy-induced bone
loss. J Cell Mol Med. 24:2294–2307. 2020. View Article : Google Scholar :
|
|
22
|
Hu W, Chen Y, Dou C and Dong S:
Microenvironment in subchondral bone: Predominant regulator for the
treatment of osteoarthritis. Ann Rheum Dis. 80:413–422. 2021.
View Article : Google Scholar :
|
|
23
|
Li B, Lee W, Song C, Ye L, Abel ED and
Long F: Both aerobic glycolysis and mitochondrial respiration are
required for osteoclast differentiation. FASEB J. 34:11058–11067.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Nishioku T, Anzai R, Hiramatsu S, Terazono
A, Nakao M and Moriyama M: Lactate dehydrogenase A inhibition
prevents RANKL-induced osteoclastogenesis by reducing enhanced
glycolysis. J Pharmacol Sci. 153:197–207. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Peng X and Du J: Histone and non-histone
lactylation: Molecular mechanisms, biological functions, diseases,
and therapeutic targets. Mol Biomed. 6:382025. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Galle E, Wong CW, Ghosh A, Desgeorges T,
Melrose K, Hinte LC, Castellano-Castillo D, Engl M, de Sousa JA,
Ruiz-Ojeda FJ, et al: H3K18 lactylation marks tissue-specific
active enhancers. Genome Biol. 23:2072022. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Rathod B, Desai S, Samvelyan HJ, Bock L,
Wu J, Ohlsson C, Palmquist A, Alm JJ, Newton PT, Andersson G and
Windahl SH: Tartrate-resistant acid phosphatase (TRAP/ACP5)
promotes bone length, regulates cortical and trabecular bone mass,
and maintains growth plate architecture and width in a sex- and
site-specific manner in mice. Bone. 188:1172232024. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Ivanova MM, Dao J, Loynab N, Noor S,
Kasaci N, Friedman A and Goker-Alpan O: The expression and
secretion profile of TRAP5 isoforms in gaucher disease. Cells.
13:7162024. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Shen Y, Mao Z, Chen H, Zhu W, Guan Q, Yang
Y, Liu J and Li L: Exercise-specific post-translational
modification signatures: Unveiling precise regulatory mechanisms of
molecular exercise language and cellular adaptation. Front Sports
Act Living. 8:17651702026. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Balsalobre A and Drouin J: Pioneer factors
as master regulators of the epigenome and cell fate. Nat Rev Mol
Cell Biol. 23:449–464. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Chisolm DA and Weinmann AS: Connections
between metabolism and epigenetics in programming cellular
differentiation. Annu Rev Immunol. 36:221–246. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Zheng J, Lu Y, Lin Y, Si S, Guo B, Zhao X
and Cui L: Epitranscriptomic modifications in mesenchymal stem cell
differentiation: Advances, mechanistic insights, and beyond. Cell
Death Differ. 31:9–27. 2024. View Article : Google Scholar
|
|
33
|
Cheung KC, Ma J, Wang L, Chen X, Fanti S,
Li M, Azevedo LR, Gosselet F, Shen H, Zheng X, et al: CD31
orchestrates metabolic regulation in autophagy pathways of
rheumatoid arthritis. Pharmacol Res. 207:1073462024. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Zhu Z, Chen Y, Zou J, Gao S, Wu D, Li X,
Hu N, Zhao J, Huang W and Chen H: Lactate mediates the bone
anabolic effect of High-intensity interval training by inducing
osteoblast differentiation. J Bone Joint Surg Am. 105:369–379.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Pucino V, Nefla M, Gauthier V, Alsaleh G,
Clayton SA, Marshall J, Filer A, Clark AR, Raza K and Buckley CD:
Differential effect of lactate on synovial fibroblast and
macrophage effector functions. Front Immunol. 14:11838252023.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Da W, Tao L and Zhu Y: The role of
osteoclast energy metabolism in the occurrence and development of
osteoporosis. Front Endocrinol (Lausanne). 12:6753852021.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Estell E, Ichikawa T, Giffault P, Bonewald
L, Spiegelman B and Rosen C: Irisin enhances mitochondrial function
in osteoclast progenitors during differentiation. Biomedicines.
11:33112023. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Chen L, Su Y, Wang C, Huang Q, Chen W, Hai
N, Wang J, Lian H, Zhao J, Xu J and Liu O: Rc3h1 negatively
regulates osteoclastogenesis by limiting energy metabolism.
Theranostics. 14:7554–7568. 2024. View Article : Google Scholar : PubMed/NCBI
|