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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August-2026 Volume 58 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Review Open Access

Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

  • Authors:
    • Kebing Lv
    • Zijie Ma
    • Qiuni Chen
    • Yang Su
    • Jingjing Ma
    • Chunling Wang
    • Liang Yu

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China
    Copyright: © Lv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 230
    |
    Published online on: June 23, 2026
       https://doi.org/10.3892/ijmm.2026.5901
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Abstract

Patients with cancer, particularly those diagnosed with hematological malignancies, exhibit thrombus incidence rates that exceed those observed in the general population by a substantial margin, and this elevated risk is associated with worse clinical outcomes. Neutrophil extracellular traps (NETs), which are web‑like structures released by neutrophils as part of their innate immune repertoire, drive coagulation and vascular occlusion by supplying a physical scaffold, recruiting procoagulant factors, and cleaving tissue factor pathway inhibitors. In hematological malignancies, emerging evidence points to NET overproduction and dysregulation as key drivers of thrombosis, representing a previously underappreciated mechanistic axis. The present review focuses on the molecular mechanisms by which NETs promote thrombosis, specifically on thrombosis associated with hematological malignancies (such as myeloproliferative neoplasm, acute myeloid leukemia, Hodgkin lymphoma, multiple myeloma and acute lymphoblastic leukemia), and also explores the clinical translation potential of NET‑related therapies. The present study offers a potential basis for refining current approaches to coagulation risk reduction in patients with hematological malignancies.

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Copy and paste a formatted citation
Spandidos Publications style
Lv K, Ma Z, Chen Q, Su Y, Ma J, Wang C and Yu L: Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review). Int J Mol Med 58: 230, 2026.
APA
Lv, K., Ma, Z., Chen, Q., Su, Y., Ma, J., Wang, C., & Yu, L. (2026). Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review). International Journal of Molecular Medicine, 58, 230. https://doi.org/10.3892/ijmm.2026.5901
MLA
Lv, K., Ma, Z., Chen, Q., Su, Y., Ma, J., Wang, C., Yu, L."Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)". International Journal of Molecular Medicine 58.2 (2026): 230.
Chicago
Lv, K., Ma, Z., Chen, Q., Su, Y., Ma, J., Wang, C., Yu, L."Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)". International Journal of Molecular Medicine 58, no. 2 (2026): 230. https://doi.org/10.3892/ijmm.2026.5901
Copy and paste a formatted citation
x
Spandidos Publications style
Lv K, Ma Z, Chen Q, Su Y, Ma J, Wang C and Yu L: Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review). Int J Mol Med 58: 230, 2026.
APA
Lv, K., Ma, Z., Chen, Q., Su, Y., Ma, J., Wang, C., & Yu, L. (2026). Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review). International Journal of Molecular Medicine, 58, 230. https://doi.org/10.3892/ijmm.2026.5901
MLA
Lv, K., Ma, Z., Chen, Q., Su, Y., Ma, J., Wang, C., Yu, L."Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)". International Journal of Molecular Medicine 58.2 (2026): 230.
Chicago
Lv, K., Ma, Z., Chen, Q., Su, Y., Ma, J., Wang, C., Yu, L."Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)". International Journal of Molecular Medicine 58, no. 2 (2026): 230. https://doi.org/10.3892/ijmm.2026.5901
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