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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December-2026 Volume 58 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review Open Access

From RNA fate to cancer state transitions: m5C‑driven metabolic and immune reprogramming (Review)

  • Authors:
    • Yuanli Zhou
    • Bolv Zhu
    • Xingzhou Tang
    • Shuishui Yin

  • View Affiliations / Copyright

    Affiliations: Second Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550001, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 348
    |
    Published online on: October 20, 2026
       https://doi.org/10.3892/ijmm.2026.6019
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Abstract

RNA 5‑methylcytosine (m5C) regulates RNA stability, processing and translation, linking changes in nutrient supply and stress to cancer‑cell behavior. Its consequences depend on the RNA substrate and the proteins that recognize or process the modification. This dependence helps explain why NOP2/Sun RNA methyltransferase 2 (NSUN2), NOP2 nucleolar protein, NSUN5, NSUN6 and tRNA aspartic acid methyltransferase 1 can affect proliferation, metabolism, immunity and treatment response differently. Across coding and noncoding RNAs, m5C regulation can sustain growth‑related protein expression, alter DNA damage repair and support metabolic defenses against cell death. Metabolites also regulate writers and readers, creating feedback in specific tumor models that connects nutrient availability with RNA recognition. These relationships suggest several therapeutic approaches, including nucleoside analogues, writer or reader inhibition, substrate‑RNA targeting and tumor‑directed delivery. Experimental combinations can restore drug sensitivity, although simultaneous effects on immune cells or normal tissues may limit systemic treatment. Clinical translation requires relating treatment‑induced RNA changes to drug exposure, tumor selectivity and immune‑cell function, rather than relying on regulator expression alone.

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Copy and paste a formatted citation
Spandidos Publications style
Zhou Y, Zhu B, Tang X and Yin S: From RNA fate to cancer state transitions: m5C‑driven metabolic and immune reprogramming (Review). Int J Mol Med 58: 348, 2026.
APA
Zhou, Y., Zhu, B., Tang, X., & Yin, S. (2026). From RNA fate to cancer state transitions: m5C‑driven metabolic and immune reprogramming (Review). International Journal of Molecular Medicine, 58, 348. https://doi.org/10.3892/ijmm.2026.6019
MLA
Zhou, Y., Zhu, B., Tang, X., Yin, S."From RNA fate to cancer state transitions: m5C‑driven metabolic and immune reprogramming (Review)". International Journal of Molecular Medicine 58.6 (2026): 348.
Chicago
Zhou, Y., Zhu, B., Tang, X., Yin, S."From RNA fate to cancer state transitions: m5C‑driven metabolic and immune reprogramming (Review)". International Journal of Molecular Medicine 58, no. 6 (2026): 348. https://doi.org/10.3892/ijmm.2026.6019
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Y, Zhu B, Tang X and Yin S: From RNA fate to cancer state transitions: m5C‑driven metabolic and immune reprogramming (Review). Int J Mol Med 58: 348, 2026.
APA
Zhou, Y., Zhu, B., Tang, X., & Yin, S. (2026). From RNA fate to cancer state transitions: m5C‑driven metabolic and immune reprogramming (Review). International Journal of Molecular Medicine, 58, 348. https://doi.org/10.3892/ijmm.2026.6019
MLA
Zhou, Y., Zhu, B., Tang, X., Yin, S."From RNA fate to cancer state transitions: m5C‑driven metabolic and immune reprogramming (Review)". International Journal of Molecular Medicine 58.6 (2026): 348.
Chicago
Zhou, Y., Zhu, B., Tang, X., Yin, S."From RNA fate to cancer state transitions: m5C‑driven metabolic and immune reprogramming (Review)". International Journal of Molecular Medicine 58, no. 6 (2026): 348. https://doi.org/10.3892/ijmm.2026.6019
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