Aqueous extract of the Helianthus annuus seed alleviates asthmatic symptoms in vivo

  • Authors:
    • Jin-Chul Heo
    • Sang-Uk Woo
    • Mi-Ae Kweon
    • Ja-Young Park
    • Hee Kyung Lee
    • Minsik Son
    • Jae-Rang Rho
    • Sang-Han Lee
  • View Affiliations

  • Published online on: January 1, 2008     https://doi.org/10.3892/ijmm.21.1.57
  • Pages: 57-61
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Abstract

Molecular inflammation is a pivotal process in various degenerative immune diseases, including asthma and atopic dermatitis. In this study, we examined the effects of Helianthus annuus seed (HAS) aqueous extract on an in vivo anti-asthmatic model. Ovalbumin-induced mice were orally administered the aqueous extract of Helianthus annuus seeds, and their lungs were assessed by hematoxylin and eosin staining. Moreover, the expression levels of IL-4/IL-13 cytokines and IgE were determined. HAS extract induced a decrease in CD4+ cell number, IL-4/IL-13 expression, and IgE secretion levels in the lungs. Our findings collectively suggest that the HAS extract has considerable potential in reducing the asthma-like symptoms induced by a mouse ovalbumin challenge model. However, further isolation and purification of the extract is required to determine the specific factor(s) responsible for its anti-asthmatic activity.

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January 2008
Volume 21 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Heo J, Woo S, Kweon M, Park J, Lee HK, Son M, Rho J and Lee S: Aqueous extract of the Helianthus annuus seed alleviates asthmatic symptoms in vivo. Int J Mol Med 21: 57-61, 2008
APA
Heo, J., Woo, S., Kweon, M., Park, J., Lee, H.K., Son, M. ... Lee, S. (2008). Aqueous extract of the Helianthus annuus seed alleviates asthmatic symptoms in vivo. International Journal of Molecular Medicine, 21, 57-61. https://doi.org/10.3892/ijmm.21.1.57
MLA
Heo, J., Woo, S., Kweon, M., Park, J., Lee, H. K., Son, M., Rho, J., Lee, S."Aqueous extract of the Helianthus annuus seed alleviates asthmatic symptoms in vivo". International Journal of Molecular Medicine 21.1 (2008): 57-61.
Chicago
Heo, J., Woo, S., Kweon, M., Park, J., Lee, H. K., Son, M., Rho, J., Lee, S."Aqueous extract of the Helianthus annuus seed alleviates asthmatic symptoms in vivo". International Journal of Molecular Medicine 21, no. 1 (2008): 57-61. https://doi.org/10.3892/ijmm.21.1.57