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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2008 Volume 21 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2008 Volume 21 Issue 2

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Article

Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency

  • Authors:
    • Rong Jin
    • Hideo Kaneko
    • Hiroko Suzuki
    • Takahiro Arai
    • Takahide Teramoto
    • Toshiyuki Fukao
    • Naomi Kondo

  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan
  • Pages: 233-238
    |
    Published online on: February 1, 2008
       https://doi.org/10.3892/ijmm.21.2.233
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Abstract

In some patients with common variable immunodeficiency (CVID) and immunoglobulin (Ig) A deficiency (IgAD), tumor necrosis factor (TNF) family receptor transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) gene mutations have been reported. B cells from individuals with TACI mutations do not produce IgG and IgA in response to the TACI ligand a proliferation-inducing ligand (APRIL) which probably suggests impaired isotype switching. To clarify the pathogenesis of CVID and IgAD of Japanese patients, we investigated the mutations of TNF family members TACI, APRIL, B-cell activating factor (BAFF), B-cell maturation antigen (BCMA) and BAFF receptor (BAFF-R) genes and the expression levels of BAFF and APRIL in patients with CVID, IgAD and X-linked agammaglobulinaemia (XLA). We also investigated the relationship between age and the blood plasma levels of BAFF and APRIL. The causative gene mutations of TNF family members in our patients were not detected. In healthy subjects, the BAFF and APRIL plasma levels correlated inversely with age. The BAFF and APRIL plasma levels of patients with CVID, IgAD and XLA were significantly higher than those of healthy children. Elevated BAFF and APRIL expression levels might partially reflect the common immunological feature of primary antibody deficiency.

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Copy and paste a formatted citation
Spandidos Publications style
Jin R, Kaneko H, Suzuki H, Arai T, Teramoto T, Fukao T and Kondo N: Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency. Int J Mol Med 21: 233-238, 2008.
APA
Jin, R., Kaneko, H., Suzuki, H., Arai, T., Teramoto, T., Fukao, T., & Kondo, N. (2008). Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency. International Journal of Molecular Medicine, 21, 233-238. https://doi.org/10.3892/ijmm.21.2.233
MLA
Jin, R., Kaneko, H., Suzuki, H., Arai, T., Teramoto, T., Fukao, T., Kondo, N."Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency". International Journal of Molecular Medicine 21.2 (2008): 233-238.
Chicago
Jin, R., Kaneko, H., Suzuki, H., Arai, T., Teramoto, T., Fukao, T., Kondo, N."Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency". International Journal of Molecular Medicine 21, no. 2 (2008): 233-238. https://doi.org/10.3892/ijmm.21.2.233
Copy and paste a formatted citation
x
Spandidos Publications style
Jin R, Kaneko H, Suzuki H, Arai T, Teramoto T, Fukao T and Kondo N: Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency. Int J Mol Med 21: 233-238, 2008.
APA
Jin, R., Kaneko, H., Suzuki, H., Arai, T., Teramoto, T., Fukao, T., & Kondo, N. (2008). Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency. International Journal of Molecular Medicine, 21, 233-238. https://doi.org/10.3892/ijmm.21.2.233
MLA
Jin, R., Kaneko, H., Suzuki, H., Arai, T., Teramoto, T., Fukao, T., Kondo, N."Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency". International Journal of Molecular Medicine 21.2 (2008): 233-238.
Chicago
Jin, R., Kaneko, H., Suzuki, H., Arai, T., Teramoto, T., Fukao, T., Kondo, N."Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency". International Journal of Molecular Medicine 21, no. 2 (2008): 233-238. https://doi.org/10.3892/ijmm.21.2.233
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