Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)

  • Authors:
    • Faizeh Al-Quobaili
    • Mathias Montenarh
  • View Affiliations

  • Published online on: April 1, 2008     https://doi.org/10.3892/ijmm.21.4.399
  • Pages: 399-404
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Abstract

The homeobox domain transcription factor PDX-1 is essential for pancreatic development and for the maintenance of β-cell function. The participation of pancreatic duodenal homeobox factor-1 (PDX-1) in the transcription of several genes which are essential for glucose sensing and insulin synthesis underlines its key role in β-cells of the pancreas. PDX-1 binds to the promoter of insulin, glucose transporter 2, and glucokinase and regulates their expression. By protein-protein interaction, PDX-1 acts in concert with other transcription factors or coactivators at the level of the insulin promoter. Ectopic expression of PDX-1 together with other cofactors can re-program cells to behave like β-cells and produce insulin. This property of PDX-1 opens new strategies for the treatment of diabetes. Little is known about its regulation at the posttranslational level. Here, we report on its DNA-binding activity, the nuclear import and on post-translational modifications such as phosphorylation, glycosylation and sumoylation. Modulation of these post-translational modifications may be an alternate strategy for treating diabetes.

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April 2008
Volume 21 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Al-Quobaili F and Al-Quobaili F: Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review). Int J Mol Med 21: 399-404, 2008
APA
Al-Quobaili, F., & Al-Quobaili, F. (2008). Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review). International Journal of Molecular Medicine, 21, 399-404. https://doi.org/10.3892/ijmm.21.4.399
MLA
Al-Quobaili, F., Montenarh, M."Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)". International Journal of Molecular Medicine 21.4 (2008): 399-404.
Chicago
Al-Quobaili, F., Montenarh, M."Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)". International Journal of Molecular Medicine 21, no. 4 (2008): 399-404. https://doi.org/10.3892/ijmm.21.4.399