The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-α

  • Authors:
    • Akihiro Asakawa
    • Megumi Toyoshima
    • Kouji H. Harada
    • Mineko Fujimiya
    • Kayoko Inoue
    • Akio Koizumi
  • View Affiliations

  • Published online on: April 1, 2008     https://doi.org/10.3892/ijmm.21.4.439
  • Pages: 439-445
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Abstract

Perfluorinated compounds (PFCs) have been employed as surface treatment agents in a variety of products. Perfluorooctanoic acid (PFOA), a PFC that is found globally in the environment and in human tissues, has been increasing significantly in serum levels over the past 50 years. Here, we demonstrated that PFOA inhibits feeding behavior as potently as the endogenous peroxisome proliferator-activated receptor (PPAR)-α ligand, oleoylethanolamide (OEA), via the activation of PPAR-α, the vagal nerve and hypothalamic neuropeptides. Peripherally administered PFOA decreased food intake as potently as OEA. PFOA decreased gastric emptying and increased the expression level of the gene encoding urocortin 1 in the hypothalamus and the immunoreaction for urocortin 1 in the paraventricular nucleus. Vagotomy attenuated the inhibitory effects of PFOA on feeding. The inhibition of food intake and body-weight gain by PFOA was completely mitigated in PPAR-α−/−mice. Our studies demonstrated that the ubiquitous environmental pollutant PFOA works as an imitator of OEA mimicking its action in the feeding regulatory system, providing a new mode of action as represented by environmental ‘anorexigens’.

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April 2008
Volume 21 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Asakawa A, Toyoshima M, Harada KH, Fujimiya M, Inoue K and Koizumi A: The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-α. Int J Mol Med 21: 439-445, 2008
APA
Asakawa, A., Toyoshima, M., Harada, K.H., Fujimiya, M., Inoue, K., & Koizumi, A. (2008). The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-α. International Journal of Molecular Medicine, 21, 439-445. https://doi.org/10.3892/ijmm.21.4.439
MLA
Asakawa, A., Toyoshima, M., Harada, K. H., Fujimiya, M., Inoue, K., Koizumi, A."The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-α". International Journal of Molecular Medicine 21.4 (2008): 439-445.
Chicago
Asakawa, A., Toyoshima, M., Harada, K. H., Fujimiya, M., Inoue, K., Koizumi, A."The ubiquitous environmental pollutant perfluorooctanoicacid inhibits feeding behavior via peroxisome proliferator-activated receptor-α". International Journal of Molecular Medicine 21, no. 4 (2008): 439-445. https://doi.org/10.3892/ijmm.21.4.439