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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2008 Volume 21 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

MLE activates transcription via the minimal transactivation domain in Drosophila

  • Authors:
    • Satoko Aratani
    • Yuji Kageyama
    • Akira Nakamura
    • Hidetoshi Fujita
    • Ryoji Fujii
    • Kusuki Nishioka
    • Toshihiro Nakajima

  • View Affiliations / Copyright

    Affiliations: Department of Locomotor Science, Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Kanagawa 216-8512
  • Pages: 469-476
    |
    Published online on: April 1, 2008
       https://doi.org/10.3892/ijmm.21.4.469
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Abstract

Transcription levels of the genes on X chromosome are regulated through the dosage compensation mechanisms. The dosage compensation complex (DCC) localizes to X chromosome and activates the transcription of target genes in male 2-fold more than in female. Drosophila maleless (MLE), an ATPase/helicase, is a component of the DCC and essential for the viability of male flies. However, the functions of MLE on gene expression are not clear. RNA helicase A (RHA) is a homologue of Drosophila MLE and mediates the expression of several genes. RHA recruits preinitiation complex via the minimal transactivation domain (MTAD), consisting of 50 amino acids to target promoters. The tryptophan residues in MTAD are important for transactivation via RHA. The amino acid sequence of MTAD is conserved in MLE. In this study, we assessed whether the functions of MTAD are conserved in fruit fly by investigating the transcriptional activity of MLE. Transactivation assay indicated the MTAD of MLE had transcriptional activity in Schneider's cells. In vitro binding assays revealed that MLE recruited RNA polymerase II (Pol II) complexes through MTAD. Reporter assays showed that the MTAD, especially tryptophan residues, is important for transcription from roX promoter, similar to RHA. The results confirm that MTAD of MLE mediates the expression of MLE target genes through recruitment of Pol II.

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Copy and paste a formatted citation
Spandidos Publications style
Aratani S, Kageyama Y, Nakamura A, Fujita H, Fujii R, Nishioka K and Nakajima T: MLE activates transcription via the minimal transactivation domain in Drosophila. Int J Mol Med 21: 469-476, 2008.
APA
Aratani, S., Kageyama, Y., Nakamura, A., Fujita, H., Fujii, R., Nishioka, K., & Nakajima, T. (2008). MLE activates transcription via the minimal transactivation domain in Drosophila. International Journal of Molecular Medicine, 21, 469-476. https://doi.org/10.3892/ijmm.21.4.469
MLA
Aratani, S., Kageyama, Y., Nakamura, A., Fujita, H., Fujii, R., Nishioka, K., Nakajima, T."MLE activates transcription via the minimal transactivation domain in Drosophila". International Journal of Molecular Medicine 21.4 (2008): 469-476.
Chicago
Aratani, S., Kageyama, Y., Nakamura, A., Fujita, H., Fujii, R., Nishioka, K., Nakajima, T."MLE activates transcription via the minimal transactivation domain in Drosophila". International Journal of Molecular Medicine 21, no. 4 (2008): 469-476. https://doi.org/10.3892/ijmm.21.4.469
Copy and paste a formatted citation
x
Spandidos Publications style
Aratani S, Kageyama Y, Nakamura A, Fujita H, Fujii R, Nishioka K and Nakajima T: MLE activates transcription via the minimal transactivation domain in Drosophila. Int J Mol Med 21: 469-476, 2008.
APA
Aratani, S., Kageyama, Y., Nakamura, A., Fujita, H., Fujii, R., Nishioka, K., & Nakajima, T. (2008). MLE activates transcription via the minimal transactivation domain in Drosophila. International Journal of Molecular Medicine, 21, 469-476. https://doi.org/10.3892/ijmm.21.4.469
MLA
Aratani, S., Kageyama, Y., Nakamura, A., Fujita, H., Fujii, R., Nishioka, K., Nakajima, T."MLE activates transcription via the minimal transactivation domain in Drosophila". International Journal of Molecular Medicine 21.4 (2008): 469-476.
Chicago
Aratani, S., Kageyama, Y., Nakamura, A., Fujita, H., Fujii, R., Nishioka, K., Nakajima, T."MLE activates transcription via the minimal transactivation domain in Drosophila". International Journal of Molecular Medicine 21, no. 4 (2008): 469-476. https://doi.org/10.3892/ijmm.21.4.469
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