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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Feb 1999 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Feb 1999 Volume 3 Issue 2

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Article

The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells.

  • Authors:
    • N Mugita
    • Y Honda
    • H Nakamura
    • T Fujiwara
    • K Tanaka
    • S Omura
    • N Shimbara
    • M Ogawa
    • H Saya
    • M Nakao

  • View Affiliations / Copyright

    Affiliations: Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan.
  • Pages: 127-164
    |
    Published online on: February 1, 1999
       https://doi.org/10.3892/ijmm.3.2.127
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Abstract

The murine C2C12 myocytes terminally differentiate to myotubes in the mitogen-depletion, and a portion of the cells undergo apoptosis. In this study, a specific proteasome inhibitor lactacystin induced cell cycle withdrawal and precocious expression of myosin in C2C12 cells in mitogen-enriched medium, but these cells did not fuse to form myotubes. Mitogen-starved myocytes could not differentiate to myotubes under the proteasome inhibition. The genes for p21, MyoD, Myogenin and RB were activated, and p27 gene was repressed under the proteasome inhibition, suggesting the transcriptional regulation of these genes linked to the proteasome activity. The induction of p21 prior to MyoD may contribute to the incomplete myogenesis in the presence of lactacystin. In addition, lactacystin-treated C2C12 cells did not undergo apoptosis, while proteasome accumulated in the nuclei of apoptotic cells but not in those of myotubes during mitogen-depleted differentiation. Further, lactacystin induced similarly incomplete differentiation in human RD embryonal rhabdomyosarcoma cells. Our findings demonstrated that proteasome has an essential role in myogenesis, especially in transcriptional control of myogenic and cell cycle regulators, cell fusion forming myotubes, and apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Mugita N, Honda Y, Nakamura H, Fujiwara T, Tanaka K, Omura S, Shimbara N, Ogawa M, Saya H, Nakao M, Nakao M, et al: The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells.. Int J Mol Med 3: 127-164, 1999.
APA
Mugita, N., Honda, Y., Nakamura, H., Fujiwara, T., Tanaka, K., Omura, S. ... Nakao, M. (1999). The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells.. International Journal of Molecular Medicine, 3, 127-164. https://doi.org/10.3892/ijmm.3.2.127
MLA
Mugita, N., Honda, Y., Nakamura, H., Fujiwara, T., Tanaka, K., Omura, S., Shimbara, N., Ogawa, M., Saya, H., Nakao, M."The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells.". International Journal of Molecular Medicine 3.2 (1999): 127-164.
Chicago
Mugita, N., Honda, Y., Nakamura, H., Fujiwara, T., Tanaka, K., Omura, S., Shimbara, N., Ogawa, M., Saya, H., Nakao, M."The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells.". International Journal of Molecular Medicine 3, no. 2 (1999): 127-164. https://doi.org/10.3892/ijmm.3.2.127
Copy and paste a formatted citation
x
Spandidos Publications style
Mugita N, Honda Y, Nakamura H, Fujiwara T, Tanaka K, Omura S, Shimbara N, Ogawa M, Saya H, Nakao M, Nakao M, et al: The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells.. Int J Mol Med 3: 127-164, 1999.
APA
Mugita, N., Honda, Y., Nakamura, H., Fujiwara, T., Tanaka, K., Omura, S. ... Nakao, M. (1999). The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells.. International Journal of Molecular Medicine, 3, 127-164. https://doi.org/10.3892/ijmm.3.2.127
MLA
Mugita, N., Honda, Y., Nakamura, H., Fujiwara, T., Tanaka, K., Omura, S., Shimbara, N., Ogawa, M., Saya, H., Nakao, M."The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells.". International Journal of Molecular Medicine 3.2 (1999): 127-164.
Chicago
Mugita, N., Honda, Y., Nakamura, H., Fujiwara, T., Tanaka, K., Omura, S., Shimbara, N., Ogawa, M., Saya, H., Nakao, M."The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells.". International Journal of Molecular Medicine 3, no. 2 (1999): 127-164. https://doi.org/10.3892/ijmm.3.2.127
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