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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Feb 1999 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Feb 1999 Volume 3 Issue 2

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Article

Renal bradykinin receptors: localisation, transduction pathways and molecular basis for a possible pathological role (review).

  • Authors:
    • J P Schanstra
    • C Alric
    • M E Marin-Castaño
    • J P Girolami
    • J L Bascands

  • View Affiliations / Copyright

    Affiliations: INSERM U388, Institut Louis Bugnard, CHU Rangueil, 31054 Toulouse cedex, France.
  • Pages: 185-276
    |
    Published online on: February 1, 1999
       https://doi.org/10.3892/ijmm.3.2.185
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Abstract

Kinins are biologically active peptides that exert their effects by activating two seven transmembrane G-protein coupled receptors termed B1 and B2 which have only about 36% of homology. The major kinin peptide under physiological conditions, bradykinin (BK), modulates renal haemodynamics and function. Under physiological conditions most BK effects involve bradykinin B2-receptors. Studies on the intra-cellular transduction pathways, the regulation of the expression and the localisation of these receptors along the nephron, as well as the first studies on transgenic mice models, have allowed to better define the role of these receptors under physiological and pathological conditions. The role of the renal B1-receptor, induced in a variety of pathologies related to inflammation, is poorly understood. Recent investigations on the molecular mechanism of B1-receptor induction and its detailed renal localisation have shown that under inflammatory conditions this kinin receptor might be of importance. B2-receptors are suggested to be involved in part of the renoprotective effects of angiotensin converting enzyme (ACE)-inhibitors in insulin-dependent diabetes. However, ACE-inhibitor treatment, resulting also in an increased B1-agonist concentration might result in homologous induction and activation of the B1-receptor.

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Copy and paste a formatted citation
Spandidos Publications style
Schanstra J, Alric C, Marin-Castaño M, Girolami J and Bascands J: Renal bradykinin receptors: localisation, transduction pathways and molecular basis for a possible pathological role (review).. Int J Mol Med 3: 185-276, 1999.
APA
Schanstra, J., Alric, C., Marin-Castaño, M., Girolami, J., & Bascands, J. (1999). Renal bradykinin receptors: localisation, transduction pathways and molecular basis for a possible pathological role (review).. International Journal of Molecular Medicine, 3, 185-276. https://doi.org/10.3892/ijmm.3.2.185
MLA
Schanstra, J., Alric, C., Marin-Castaño, M., Girolami, J., Bascands, J."Renal bradykinin receptors: localisation, transduction pathways and molecular basis for a possible pathological role (review).". International Journal of Molecular Medicine 3.2 (1999): 185-276.
Chicago
Schanstra, J., Alric, C., Marin-Castaño, M., Girolami, J., Bascands, J."Renal bradykinin receptors: localisation, transduction pathways and molecular basis for a possible pathological role (review).". International Journal of Molecular Medicine 3, no. 2 (1999): 185-276. https://doi.org/10.3892/ijmm.3.2.185
Copy and paste a formatted citation
x
Spandidos Publications style
Schanstra J, Alric C, Marin-Castaño M, Girolami J and Bascands J: Renal bradykinin receptors: localisation, transduction pathways and molecular basis for a possible pathological role (review).. Int J Mol Med 3: 185-276, 1999.
APA
Schanstra, J., Alric, C., Marin-Castaño, M., Girolami, J., & Bascands, J. (1999). Renal bradykinin receptors: localisation, transduction pathways and molecular basis for a possible pathological role (review).. International Journal of Molecular Medicine, 3, 185-276. https://doi.org/10.3892/ijmm.3.2.185
MLA
Schanstra, J., Alric, C., Marin-Castaño, M., Girolami, J., Bascands, J."Renal bradykinin receptors: localisation, transduction pathways and molecular basis for a possible pathological role (review).". International Journal of Molecular Medicine 3.2 (1999): 185-276.
Chicago
Schanstra, J., Alric, C., Marin-Castaño, M., Girolami, J., Bascands, J."Renal bradykinin receptors: localisation, transduction pathways and molecular basis for a possible pathological role (review).". International Journal of Molecular Medicine 3, no. 2 (1999): 185-276. https://doi.org/10.3892/ijmm.3.2.185
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