Application of preformed hammerhead ribozymes in the gene therapy of cancer (review).

  • Authors:
    • M Sioud
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  • Published online on: April 1, 1999     https://doi.org/10.3892/ijmm.3.4.381
  • Pages: 381-385
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Abstract

Inhibition of gene expression is an important experimental method to determine the function of genes, and could have a great impact upon the treatment of diseases in which gene products are involved. Catalytic RNAs (ribozymes) with endoribonuclease activity are RNA molecules that site-specifically cleave other RNAs, and thus have tremendous potential as novel therapeutic agents. The capacity of these agents to suppress gene expression in a wide range of systems strengthens the importance of this novel gene-based therapy, and indicate that preformed ribozymes may be useful as pharmaceuticals.

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Apr 1999
Volume 3 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Sioud M: Application of preformed hammerhead ribozymes in the gene therapy of cancer (review).. Int J Mol Med 3: 381-385, 1999
APA
Sioud, M. (1999). Application of preformed hammerhead ribozymes in the gene therapy of cancer (review).. International Journal of Molecular Medicine, 3, 381-385. https://doi.org/10.3892/ijmm.3.4.381
MLA
Sioud, M."Application of preformed hammerhead ribozymes in the gene therapy of cancer (review).". International Journal of Molecular Medicine 3.4 (1999): 381-385.
Chicago
Sioud, M."Application of preformed hammerhead ribozymes in the gene therapy of cancer (review).". International Journal of Molecular Medicine 3, no. 4 (1999): 381-385. https://doi.org/10.3892/ijmm.3.4.381