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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
Apr 1999 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Apr 1999 Volume 3 Issue 4

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Article

Plasticity-related serine proteases in the brain (review).

  • Authors:
    • S Yoshida
    • S Shiosaka

  • View Affiliations / Copyright

    Affiliations: Division of Structural Cell Biology, Nara Institute of Science and Technology, Ikoma, Nara 630-0101, Japan.
  • Pages: 405-414
    |
    Published online on: April 1, 1999
       https://doi.org/10.3892/ijmm.3.4.405
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Abstract

Serine proteases exert a variety of functions in the body; food digestion, regulation of other proteins and modification of extracellular matrix. Cumulative evidence has shown the importance of serine proteases in the nervous system as well. It has been shown that three serine proteases, thrombin, plasminogen activators and neuropsin, have functional roles in neural plasticity. Most of the actions of thrombin are thought to be mediated by its specific receptors. Thrombin reverses neurite outgrowth of serum-deprived neuroblastoma cells, and induces protective and apoptotic effects on neurons and glial cells depending on concentration and time. Tissue-type and urokinase-type plasminogen activators (tPA and uPA) distribute broadly in the brain. tPA and uPA exert a variety of functions during development. These proteases also function in long-term potentiation and kindling formation. Furthermore, tPA is essential to excitotoxic neuronal cell death. Neuropsin is a serine protease expressed in the limbic system of the brain. Kindling induced neuropsin mRNA and protein expression and anti-neuropsin antibody ameliorates kindling epilepsy. The possible roles of these proteases in neural plasticity are reviewed here.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshida S and Shiosaka S: Plasticity-related serine proteases in the brain (review).. Int J Mol Med 3: 405-414, 1999.
APA
Yoshida, S., & Shiosaka, S. (1999). Plasticity-related serine proteases in the brain (review).. International Journal of Molecular Medicine, 3, 405-414. https://doi.org/10.3892/ijmm.3.4.405
MLA
Yoshida, S., Shiosaka, S."Plasticity-related serine proteases in the brain (review).". International Journal of Molecular Medicine 3.4 (1999): 405-414.
Chicago
Yoshida, S., Shiosaka, S."Plasticity-related serine proteases in the brain (review).". International Journal of Molecular Medicine 3, no. 4 (1999): 405-414. https://doi.org/10.3892/ijmm.3.4.405
Copy and paste a formatted citation
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Spandidos Publications style
Yoshida S and Shiosaka S: Plasticity-related serine proteases in the brain (review).. Int J Mol Med 3: 405-414, 1999.
APA
Yoshida, S., & Shiosaka, S. (1999). Plasticity-related serine proteases in the brain (review).. International Journal of Molecular Medicine, 3, 405-414. https://doi.org/10.3892/ijmm.3.4.405
MLA
Yoshida, S., Shiosaka, S."Plasticity-related serine proteases in the brain (review).". International Journal of Molecular Medicine 3.4 (1999): 405-414.
Chicago
Yoshida, S., Shiosaka, S."Plasticity-related serine proteases in the brain (review).". International Journal of Molecular Medicine 3, no. 4 (1999): 405-414. https://doi.org/10.3892/ijmm.3.4.405
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