Abnormal binding pattern and composition of the NF-kappaB complex components are involved in increased TNF-alpha production by tumor bearer B cells.

  • Authors:
    • V I Charyulu
    • D M Lopez
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  • Published online on: April 1, 1999     https://doi.org/10.3892/ijmm.3.4.411
  • Pages: 411-417
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Abstract

B lymphocytes from mammary tumor bearers are cytotoxic against tumor targets and produce TNF-alpha. A greater stability of RNA and a decreased rate of RNA degradation was observed in B cells of tumor bearers compared to those of normal mice. The TNF-alpha promoter contains regions that bind NF-kappaB, which regulate the rate of transcription. Supershift assays for the NF-kappaB region showed that there are p50-p65 heterodimers and p50 homodimers in the nuclear extracts of the two types of B cells, while those from tumor bearers lack the c-Rel component that is present in normal B cells. These results indicate that abnormalities in binding and composition of the NF-kappaB complexes may be involved in the increased TNF-alpha production by B cells of tumor bearers.

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Apr 1999
Volume 3 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Charyulu V and Charyulu V: Abnormal binding pattern and composition of the NF-kappaB complex components are involved in increased TNF-alpha production by tumor bearer B cells.. Int J Mol Med 3: 411-417, 1999
APA
Charyulu, V., & Charyulu, V. (1999). Abnormal binding pattern and composition of the NF-kappaB complex components are involved in increased TNF-alpha production by tumor bearer B cells.. International Journal of Molecular Medicine, 3, 411-417. https://doi.org/10.3892/ijmm.3.4.411
MLA
Charyulu, V., Lopez, D."Abnormal binding pattern and composition of the NF-kappaB complex components are involved in increased TNF-alpha production by tumor bearer B cells.". International Journal of Molecular Medicine 3.4 (1999): 411-417.
Chicago
Charyulu, V., Lopez, D."Abnormal binding pattern and composition of the NF-kappaB complex components are involved in increased TNF-alpha production by tumor bearer B cells.". International Journal of Molecular Medicine 3, no. 4 (1999): 411-417. https://doi.org/10.3892/ijmm.3.4.411