Signaling pathway and pepsinogen secretion in Helicobacter pylori-infected human gastric adenocarcinoma.

  • Authors:
    • E C Chan
    • C T Chen
    • Y L Lin
    • K T Chen
  • View Affiliations

  • Published online on: April 1, 1999     https://doi.org/10.3892/ijmm.3.4.421
  • Pages: 421-426
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Abstract

Although in vitro studies have suggested that Helicobacter pylori not only attaches to cultured cells but also induces signal transduction events in host cells, the underlying mechanism of H. pylori action has yet to be fully investigated. In the present study, a cytotoxin-positive H. pylori was used to infect and examined for its effect on the stimulation of second messengers in human gastric adenocarcinoma (AGS). Results showed that H. pylori increased cytosolic free calcium concentration [Ca2+]i in host cells in a dose-dependent manner. The increase of [Ca2+]i was due to release from the intracellular Ca2+ store as well as entry to the extracellular Ca2+. H. pylori infection on host cells was also found to induce the generations of inositol phosphates, adenosine 3', 5'-cyclic monophosphate, and guanosine 3',5'-cyclic monophosphate, and to stimulate the secretion of pepsinogen.

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Apr 1999
Volume 3 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Chan E, Chen C, Lin Y and Chen K: Signaling pathway and pepsinogen secretion in Helicobacter pylori-infected human gastric adenocarcinoma.. Int J Mol Med 3: 421-426, 1999.
APA
Chan, E., Chen, C., Lin, Y., & Chen, K. (1999). Signaling pathway and pepsinogen secretion in Helicobacter pylori-infected human gastric adenocarcinoma.. International Journal of Molecular Medicine, 3, 421-426. https://doi.org/10.3892/ijmm.3.4.421
MLA
Chan, E., Chen, C., Lin, Y., Chen, K."Signaling pathway and pepsinogen secretion in Helicobacter pylori-infected human gastric adenocarcinoma.". International Journal of Molecular Medicine 3.4 (1999): 421-426.
Chicago
Chan, E., Chen, C., Lin, Y., Chen, K."Signaling pathway and pepsinogen secretion in Helicobacter pylori-infected human gastric adenocarcinoma.". International Journal of Molecular Medicine 3, no. 4 (1999): 421-426. https://doi.org/10.3892/ijmm.3.4.421