Matrix metalloproteinase-1 expression is a prognostic factor for patients with advanced gastric cancer.

  • Authors:
    • T Inoue
    • M Yashiro
    • S Nishimura
    • K Maeda
    • T Sawada
    • Y Ogawa
    • M Sowa
    • K H Chung
  • View Affiliations

  • Published online on: July 1, 1999     https://doi.org/10.3892/ijmm.4.1.73
  • Pages: 73-80
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Abstract

Proteolytic activity of cancer cells is an important factor in metastasis. This study examined the relationship between MMP-1 expression of gastric cancer cells and peritoneal metastasis. MMP-1 expression was found in 76/103 (75.2%) cases examined and was significantly associated with both peritoneal metastasis and lymph node metastasis (p<0.05, respectively). The prognosis of patients with MMP-1 positive tumor was significantly worse than that of patients with MMP-1 negative tumor (p<0.05). These findings suggested that MMP-1 might be a prognostic factor in case of advanced gastric cancer and might be useful in determining whether or not adjuvant therapy was indicated for patients at high risk of peritoneal recurrence.

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Jul 1999
Volume 4 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Inoue T, Yashiro M, Nishimura S, Maeda K, Sawada T, Ogawa Y, Sowa M and Chung K: Matrix metalloproteinase-1 expression is a prognostic factor for patients with advanced gastric cancer.. Int J Mol Med 4: 73-80, 1999
APA
Inoue, T., Yashiro, M., Nishimura, S., Maeda, K., Sawada, T., Ogawa, Y. ... Chung, K. (1999). Matrix metalloproteinase-1 expression is a prognostic factor for patients with advanced gastric cancer.. International Journal of Molecular Medicine, 4, 73-80. https://doi.org/10.3892/ijmm.4.1.73
MLA
Inoue, T., Yashiro, M., Nishimura, S., Maeda, K., Sawada, T., Ogawa, Y., Sowa, M., Chung, K."Matrix metalloproteinase-1 expression is a prognostic factor for patients with advanced gastric cancer.". International Journal of Molecular Medicine 4.1 (1999): 73-80.
Chicago
Inoue, T., Yashiro, M., Nishimura, S., Maeda, K., Sawada, T., Ogawa, Y., Sowa, M., Chung, K."Matrix metalloproteinase-1 expression is a prognostic factor for patients with advanced gastric cancer.". International Journal of Molecular Medicine 4, no. 1 (1999): 73-80. https://doi.org/10.3892/ijmm.4.1.73