Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.

  • Authors:
    • T Okamoto
    • T Kanda
    • K Yamamura
    • O Hino
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  • Published online on: September 1, 1999     https://doi.org/10.3892/ijmm.4.3.261
  • Pages: 261-267
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Abstract

The interferon-gamma (IFN-gamma) transgenic mouse expresses the IFN-gamma gene strongly in the liver and develops chronic hepatitis from 6-10 weeks of age. Previously we reported the detection of hepatocyte apoptosis and the expression of the Fas system in the transgenic mouse liver. The objective of the present study was to examine the possible development of favorable conditions for predisposing cells to malignancy. The connection between the cell cycle and cancer has become evident, and the relation of cyclin D1 (CD1) with hepatocellular carcinomas has been strengthened. In the liver of transgenic mice of 48 weeks of age, c-myc and CD1 gene expression was induced, indicating progression of the cell cycles. p21 gene expression in the transgenic mouse liver might counteract cell-cycle progression promoted by c-myc and CD1. In the liver of 8-week-old transgenic mice, expression of c-myc mRNA was correlated with the levels of plasma transaminase activities. In these 8-week-old transgenic mice, however, CD1 mRNA was not induced, regardless of the progression of hepatitis. Based on these results, we conclude that long lasting hepatitis may lead to favorable conditions for predisposing cells to malignancy.

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Sep 1999
Volume 4 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Okamoto T, Kanda T, Yamamura K and Hino O: Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.. Int J Mol Med 4: 261-267, 1999.
APA
Okamoto, T., Kanda, T., Yamamura, K., & Hino, O. (1999). Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.. International Journal of Molecular Medicine, 4, 261-267. https://doi.org/10.3892/ijmm.4.3.261
MLA
Okamoto, T., Kanda, T., Yamamura, K., Hino, O."Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.". International Journal of Molecular Medicine 4.3 (1999): 261-267.
Chicago
Okamoto, T., Kanda, T., Yamamura, K., Hino, O."Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.". International Journal of Molecular Medicine 4, no. 3 (1999): 261-267. https://doi.org/10.3892/ijmm.4.3.261