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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Sep 1999 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Sep 1999 Volume 4 Issue 3

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Article

Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.

  • Authors:
    • T Okamoto
    • T Kanda
    • K Yamamura
    • O Hino

  • View Affiliations / Copyright

    Affiliations: Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama 341-0005, Japan.
  • Pages: 261-267
    |
    Published online on: September 1, 1999
       https://doi.org/10.3892/ijmm.4.3.261
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Abstract

The interferon-gamma (IFN-gamma) transgenic mouse expresses the IFN-gamma gene strongly in the liver and develops chronic hepatitis from 6-10 weeks of age. Previously we reported the detection of hepatocyte apoptosis and the expression of the Fas system in the transgenic mouse liver. The objective of the present study was to examine the possible development of favorable conditions for predisposing cells to malignancy. The connection between the cell cycle and cancer has become evident, and the relation of cyclin D1 (CD1) with hepatocellular carcinomas has been strengthened. In the liver of transgenic mice of 48 weeks of age, c-myc and CD1 gene expression was induced, indicating progression of the cell cycles. p21 gene expression in the transgenic mouse liver might counteract cell-cycle progression promoted by c-myc and CD1. In the liver of 8-week-old transgenic mice, expression of c-myc mRNA was correlated with the levels of plasma transaminase activities. In these 8-week-old transgenic mice, however, CD1 mRNA was not induced, regardless of the progression of hepatitis. Based on these results, we conclude that long lasting hepatitis may lead to favorable conditions for predisposing cells to malignancy.

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Copy and paste a formatted citation
Spandidos Publications style
Okamoto T, Kanda T, Yamamura K and Hino O: Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.. Int J Mol Med 4: 261-267, 1999.
APA
Okamoto, T., Kanda, T., Yamamura, K., & Hino, O. (1999). Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.. International Journal of Molecular Medicine, 4, 261-267. https://doi.org/10.3892/ijmm.4.3.261
MLA
Okamoto, T., Kanda, T., Yamamura, K., Hino, O."Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.". International Journal of Molecular Medicine 4.3 (1999): 261-267.
Chicago
Okamoto, T., Kanda, T., Yamamura, K., Hino, O."Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.". International Journal of Molecular Medicine 4, no. 3 (1999): 261-267. https://doi.org/10.3892/ijmm.4.3.261
Copy and paste a formatted citation
x
Spandidos Publications style
Okamoto T, Kanda T, Yamamura K and Hino O: Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.. Int J Mol Med 4: 261-267, 1999.
APA
Okamoto, T., Kanda, T., Yamamura, K., & Hino, O. (1999). Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.. International Journal of Molecular Medicine, 4, 261-267. https://doi.org/10.3892/ijmm.4.3.261
MLA
Okamoto, T., Kanda, T., Yamamura, K., Hino, O."Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.". International Journal of Molecular Medicine 4.3 (1999): 261-267.
Chicago
Okamoto, T., Kanda, T., Yamamura, K., Hino, O."Long lasting chronic hepatitis is accompanied by cyclin D1 gene expression in the mouse.". International Journal of Molecular Medicine 4, no. 3 (1999): 261-267. https://doi.org/10.3892/ijmm.4.3.261
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